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Overweight in midli...
Overweight in midlife and risk of dementia: a 40-year follow-up study
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- Hassing, Linda, 1967 (author)
- Gothenburg University,Göteborgs universitet,Psykologiska institutionen,Department of Psychology
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- Dahl, Anna, 1975- (author)
- Jönköping University,HHJ, Institutet för gerontologi,HHJ. Åldrande - livsvillkor och hälsa
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- Thorvaldsson, Valgeir, 1976 (author)
- Gothenburg University,Göteborgs universitet,Psykologiska institutionen,Department of Psychology
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- Berg, Stig, 1947 (author)
- Jönköping University,HHJ, Institutet för gerontologi,HHJ. Åldrande - livsvillkor och hälsa
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Gatz, Maragaret (author)
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- Pedersen, Nancy L (author)
- Karolinska Institutet
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- Johansson, Boo (author)
- Gothenburg University,Göteborgs universitet,Psykologiska institutionen,Department of Psychology
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(creator_code:org_t)
- Springer, 2009
- 2009
- English.
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In: International Journal of Obesity. - : Springer. ; 33:8, s. 893-898
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https://doi.org/10.1...
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Abstract
Subject headings
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- Objective: This study examines whether overweight in midlife increases dementia risk later in life. Methods: In 1963 body mass index was assessed in 1152 participants of The Swedish Twin Registry, at the age of 45–65 years. These participants were later screened for dementia in a prospective study with up to 40 years follow-up. A total of 312 participants were diagnosed with dementia. Results: Logistic regression analyses adjusted for demographic factors, smoking and alcohol habits, indicated that men and women categorized as overweight in their midlife had an elevated risk of dementia (OR=1.59; 95% CI: 1.21–2.07, P=0.002), Alzheimer's disease (OR=1.71; 95% CI: 1.24–2.35, P=0.003), and vascular dementia (OR=1.55; 95% CI: 0.98–2.47, P=0.059). Further adjustments for diabetes and vascular diseases did not substantially affect the associations, except for vascular dementia (OR=1.36; 95% CI: 0.82–2.56, P=0.116), reflecting the significance of diabetes and vascular diseases in the etiology of vascular dementia. There was no significant interaction between overweight and APOE alt epsilon4 status, indicating that having both risk factors does not have a multiplicative effect with regard to dementia risk. Conclusions: This study gives further support to the notion that overweight in midlife increases later risk of dementia. The risk is increased for both Alzheimer's disease and vascular dementia, and follows the same pattern for men and women. Keywords: BMI, alzheimer's disease, vascular dementia, dementia, overweight, obesity
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Geriatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Geriatrics (hsv//eng)
- SAMHÄLLSVETENSKAP -- Annan samhällsvetenskap -- Övrig annan samhällsvetenskap (hsv//swe)
- SOCIAL SCIENCES -- Other Social Sciences -- Other Social Sciences not elsewhere specified (hsv//eng)
Keyword
- BMI
- alzheimer's disease
- vascular dementia
- dementia
- overweight
- obesity
- body mass index alzheimer's disease vascular dementia dementia overweight obesity
- Geriatrics and medical gerontology
- Older people and ageing
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Hassing, Linda, ...
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Dahl, Anna, 1975 ...
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Thorvaldsson, Va ...
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Berg, Stig, 1947
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Gatz, Maragaret
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Pedersen, Nancy ...
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show more...
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Johansson, Boo
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Psychiatry
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Geriatrics
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- SOCIAL SCIENCES
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SOCIAL SCIENCES
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and Other Social Sci ...
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and Other Social Sci ...
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International Jo ...
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University of Gothenburg
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Jönköping University
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Karolinska Institutet