Adaptive properties and heterogeneity of dopamine D(2) receptors - pharmacological implications.

• In this review, we focus on the marked adaptability of dopamine D(2) receptors to varying agonist levels and we discuss the extent to which this phenomenon can account for the heterogeneity of these receptors in regard to function and pharmacological responsiveness. We emphasize the significance of a distinction between synaptic and extrasynaptic receptors in this context. For example, the application of this dichotomy appears to shed new light on the various subgroups of antipsychotic drugs and the mechanisms underlying their different profiles.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Fysiologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Physiology (hsv//eng)

Nyckelord

Adaptation

Physiological

drug effects

physiology

Animals

Dopamine Agents

pharmacology

Humans

Neuronal Plasticity

drug effects

Receptors

Dopamine D2

physiology

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)