Delayed IGF-1 administration rescues oligodendrocyte progenitors from glutamate-induced cell death and hypoxic-ischemic brain damage.

We previously demonstrated that IGF-1 blocks glutamate-mediated death of late oligodendrocyte progenitors (OPs) by preventing Bax translocation, mitochondrial cytochrome c release and cleavage of caspases 9 and 3. Here, we demonstrate that IGF-1 prevents caspase 3 activation in late OPs when administered up to 16 h following exposure to glutamate. Moreover, late addition of IGF-1 to OPs previously exposed to toxic levels of glutamate promotes oligodendrocyte maturation as measured by myelin basic protein expression. We also demonstrate that intraventricularly administered IGF-1 retains OPs in the perinatal white matter after hypoxia-ischemia when given after insult. These results suggest that delayed administration of IGF-1 will rescue OPs in the immature white matter and promote myelination following hypoxia-ischemia.

Loladze, Vaho (author)
Altieri, Stefanie (author)
Gangoli, Nitish (author)
Levison, Steven W (author)
Gustafsson Brywe, Katarina,1965Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Clinical Sciences,Institute of Neuroscience and Physiology, Department of Physiology (author)
Mallard, Carina,1963Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology(Swepub:gu)xmallc (author)
Hagberg, Henrik,1955Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institutionen för kliniska vetenskaper,Institute of Neuroscience and Physiology, Department of Physiology,Institute of Clinical Sciences(Swepub:gu)xhaghe (author)
Göteborgs universitetInstitutionen för kliniska vetenskaper (creator_code:org_t)

By the author/editor: Wood, Teresa L; Loladze, Vaho; Altieri, Stefani ...; Gangoli, Nitish; Levison, Steven ...; Gustafsson Brywe ...; show more...; Mallard, Carina, ...; Hagberg, Henrik, ...; show less...

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