Serotonin transporter gene polymorphisms and platelet [3H] paroxetine binding in premenstrual dysphoria.

• The purpose of this study was to investigate if women with premenstrual dysphoria differ from controls with respect to the number of platelet serotonin transporters, and with respect to three polymorphisms in the gene coding for the serotonin transporter: a 44 base pair insertion/deletion in the promoter region, a variable number of tandem repeats in the second intron, and a single nucleotide polymorphism in the 3' untranslated region. Also, the possible relationship between the three polymorphisms and platelet serotonin transporter density was analyzed. The density of platelet [(3)H]paroxetine binding sites was significantly lower in women with premenstrual dysphoria than in controls, but patients and controls did not differ with respect to allele or genotype frequency for any of the three polymorphisms examined. A significant association between the number of platelet serotonin transporters and the promoter polymorphism was observed, subjects being homozygous for the short (deletion) variant having higher platelet serotonin transporter density than subjects carrying the long (insertion) allele. The results support the assumption that serotonin-related psychiatric disorders-such as premenstrual dysphoria-may be associated with a reduction in platelet [(3)H]paroxetine binding, but argue against the notion that this reduction is due to certain variants of the serotonin transporter gene being more common in patients than in controls.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)

Nyckelord

Adolescent

Adult

Blood Platelets

metabolism

Carrier Proteins

genetics

Female

Gene Frequency

Genotype

Humans

Membrane Glycoproteins

genetics

Membrane Transport Proteins

Middle Aged

Nerve Tissue Proteins

Paroxetine

metabolism

Polymorphism

Genetic

Premenstrual Syndrome

genetics

metabolism

Serotonin

genetics

metabolism

Serotonin Plasma Membrane Transport Proteins

Serotonin Uptake Inhibitors

metabolism

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)