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Prevalence and prog...
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Visser, Pieter JelleDepartment of Psychiatry and Neuropsychology, Alzheimer Center Limburg, University of Maastricht, Netherlands; Department of Neurology, Alzheimer Center, VU University Medical Center, Amsterdam, Netherlands
(författare)
Prevalence and prognostic value of CSF markers of Alzheimer's disease pathology in patients with subjective cognitive impairment or mild cognitive impairment in the DESCRIPA study: a prospective cohort study.
- Artikel/kapitelEngelska2009
Förlag, utgivningsår, omfång ...
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The Lancet Publishing Group,2009
Nummerbeteckningar
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LIBRIS-ID:oai:gup.ub.gu.se/99343
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https://gup.ub.gu.se/publication/99343URI
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https://doi.org/10.1016/S1474-4422(09)70139-5DOI
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https://lup.lub.lu.se/record/1463041URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-74162URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:119018559URI
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Klassifikation
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Funding agencies:European Commission 5th Framework Programme (QLK-6-CT-2002-02455)Ana Aslan International Foundation
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BACKGROUND: Alzheimer's disease (AD) pathology is common in patients with amnestic mild cognitive impairment (aMCI) without dementia, but the prevalence of AD pathology in patients with subjective cognitive impairment (SCI) and non-amnestic mild cognitive impairment (naMCI) is unknown. AD is characterised by decreased CSF concentrations of Abeta(42) and increased concentrations of tau. We investigated the prevalence of a CSF AD profile in patients with SCI, naMCI, or aMCI and the association of this profile with cognitive outcome in each group. METHODS: Patients with SCI, naMCI, aMCI, and neurologically healthy controls were recruited from 20 memory clinics across Europe, between January, 2003, and June, 2005, into this prospective cohort study. A CSF AD profile was defined as an abnormal ratio of Abeta(42):tau. Patients were assessed annually up to 3 years. Outcome measures were changes in memory, overall cognition, mini-mental state examination (MMSE) score, daily function, and progression to AD-type dementia. FINDINGS: The CSF AD profile was more common in patients with SCI (31 of 60 [52%]), naMCI (25 of 37 [68%]), and aMCI (56 of 71 [79%]) than in healthy controls (28 of 89 [31%]). The profile was associated with cognitive decline in patients with naMCI (memory, MMSE, and daily function) and in patients with aMCI (MMSE and daily function). In patients with aMCI, a CSF AD profile was predictive of AD-type dementia (OR 26.8, 95% CI 1.6-456.4). INTERPRETATION: AD is a common cause of SCI, naMCI, and aMCI and is associated with cognitive decline in patients with naMCI or aMCI. Patients with SCI might be in the early stages of AD, and cognitive decline might become apparent only after longer follow-up. FUNDING: European Commission; Ana Aslan International Foundation.
Ämnesord och genrebeteckningar
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MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Neurologi hsv//swe
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MEDICAL AND HEALTH SCIENCES Clinical Medicine Neurology hsv//eng
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Aged
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Alzheimer Disease
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cerebrospinal fluid
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diagnosis
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physiopathology
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Amyloid beta-Protein
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analysis
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cerebrospinal fluid
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Biological Markers
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analysis
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cerebrospinal fluid
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Cognition Disorders
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cerebrospinal fluid
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diagnosis
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physiopathology
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Cohort Studies
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Disability Evaluation
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Disease Progression
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Female
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Humans
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Male
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Middle Aged
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Neuropsychological Tests
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Peptide Fragments
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analysis
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cerebrospinal fluid
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Predictive Value of Tests
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Prevalence
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Prognosis
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Prospective Studies
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Sensitivity and Specificity
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Severity of Illness Index
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tau Proteins
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analysis
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cerebrospinal fluid
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Verhey, FransDepartment of Psychiatry and Neuropsychology, Alzheimer Center Limburg, University of Maastricht, Netherlands
(författare)
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Knol, Dirk LDepartment of Clinical Epidemiology and Statistics, VU University Medical Center, Amsterdam, Netherlands
(författare)
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Scheltens, PhilipDepartment of Neurology, Alzheimer Center, VU University Medical Center, Amsterdam, Netherlands
(författare)
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Wahlund, Lars-OlofKarolinska Institutet
(författare)
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Freund-Levi, Yvonne,1956-Department of NVS, Section of Clinical Geriatrics, Karolinska Institutet, Karolinska University Hospital, Huddinge, Sweden(Swepub:oru)yfi
(författare)
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Tsolaki, MagdaAristotle University of Thessaloniki, Memory and Dementia Center, 3rd Department of Neurology, G Papanicolaou General Hospital, Thessaloniki, Greece
(författare)
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Minthon, LennartLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden(Swepub:lu)psyk-lmi
(författare)
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Wallin, ÅsaLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden(Swepub:lu)med-was
(författare)
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Hampel, HaraldAlzheimer Memorial Center, Department of Psychiatry, Ludwig-Maximilian University, Munich, Germany; Discipline of Psychiatry, School of Medicine and Trinity College Institute of Neuroscience (TCIN), Laboratory of Neuroimaging and Biomarker Research, Trinity College, University of Dublin, The Adelaide, Dublin, Ireland; Meath Hospital incorporating the National Children's Hospital (AMiNCH), Dublin, Ireland
(författare)
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Bürger, KatharinaAlzheimer Memorial Center, Department of Psychiatry, Ludwig-Maximilian University, Munich, Germany
(författare)
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Pirttila, TuulaDepartment of Neurology, University and University Hospital of Kuopio, Kuopio, Finland
(författare)
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Soininen, HilkkaDepartment of Neurology, University and University Hospital of Kuopio, Kuopio, Finland
(författare)
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Rikkert, Marcel OldeDepartment of Geriatrics, Alzheimer Center, Nijmegen Centre for Evidence Based Practice, Radboud University Medical Center, Nijmegen, Netherlands
(författare)
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Verbeek, Marcel MDepartment of Neurology, Donders Center for Brain, Cognition and Behaviour, Alzheimer Center, Radboud University Nijmegen Medical Center, Nijmegen, Netherlands
(författare)
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Spiru, Luiza“Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
(författare)
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Blennow, Kaj,1958Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,Clinical Neurochemistry Laboratory, Göteborg University, Sahlgrenska University Hospital, Mölndal, Sweden(Swepub:gu)xbleka
(författare)
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Department of Psychiatry and Neuropsychology, Alzheimer Center Limburg, University of Maastricht, Netherlands; Department of Neurology, Alzheimer Center, VU University Medical Center, Amsterdam, NetherlandsDepartment of Psychiatry and Neuropsychology, Alzheimer Center Limburg, University of Maastricht, Netherlands
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Lancet neurology: The Lancet Publishing Group8:7, s. 619-271474-44221474-4465
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Till lärosätets databas
- Av författaren/redakt...
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Visser, Pieter J ...
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Verhey, Frans
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Knol, Dirk L
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Scheltens, Phili ...
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Wahlund, Lars-Ol ...
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Freund-Levi, Yvo ...
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visa fler...
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Tsolaki, Magda
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Minthon, Lennart
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Wallin, Åsa
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Hampel, Harald
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Bürger, Katharin ...
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Pirttila, Tuula
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Soininen, Hilkka
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Rikkert, Marcel ...
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Verbeek, Marcel ...
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Spiru, Luiza
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Blennow, Kaj, 19 ...
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visa färre...
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