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Multicentre prospec...
Multicentre prospective randomised trial of tacrolimus, azathioprine and prednisolone with or without basiliximab: two-year follow-up data.
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Webb, Nicholas J A (författare)
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Prokurat, Sylwester (författare)
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Vondrak, Karel (författare)
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Watson, Alan R (författare)
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Hughes, David A (författare)
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Marks, Stephen D (författare)
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Moghal, Nadeem E (författare)
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Fitzpatrick, Maggie M (författare)
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Milford, David V (författare)
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Saleem, Moin A (författare)
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Jones, Caroline A (författare)
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- Friman, Styrbjörn, 1948 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för kirurgi,Institute of Clinical Sciences, Department of Surgery
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Van Damme-Lombaerts, Rita (författare)
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Janssen, Francoise (författare)
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Hamer, Clare (författare)
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Rhodes, Sarah (författare)
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(creator_code:org_t)
- 2009-01-01
- 2009
- Engelska.
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Ingår i: Pediatric nephrology (Berlin, Germany). - : Springer Science and Business Media LLC. - 0931-041X .- 1432-198X. ; 24:1, s. 177-82
- Relaterad länk:
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- A total of 192 children and adolescents undergoing renal transplantation were randomly chosen to receive tacrolimus, azathioprine and corticosteroids (TAS, n = 93) or tacrolimus, azathioprine, corticosteroids and two doses of basiliximab (TAS + B, n = 99). Six-month outcome data have previously been reported; this manuscript reports the 2-year data. Complete 2-year data were available on 164 (85.4%) of the original 192 patients. There was a single death in the TAS arm. Kaplan-Meier estimates of survival free of graft loss at 2 years were 94.9% in the TAS + B arm and 89.6% in the TAS arm [hazard ratio (HR) 0.52; 95% confidence interval (CI) 0.17 to 1.54, P = 0.23]. Estimates of survival free from rejection at 2 years were 75.2% in the TAS + B arm and 68.7% in the TAS arm (HR 0.81; 95% CI 0.46 to 1.40, P = 0.44). The mean estimated glomerular filtration rate (GFR) at 2 years, was 65.8 ml/min per 1.73 m(2) body surface area in the TAS arm and 66.7 ml/min per 1.73 m(2) in the TAS + B arm (P = 0.78). Blood pressure and cholesterol levels were similar in the two arms, and there was no evidence of a difference in the incidence of infection or malignancy. These data provide further evidence of a lack of benefit associated with the addition of basiliximab to a TAS regimen for European paediatric renal transplant recipients at low immunological risk.
Nyckelord
- Adolescent
- Antibodies
- Monoclonal
- therapeutic use
- Azathioprine
- therapeutic use
- Child
- Drug Therapy
- Combination
- Female
- Glomerular Filtration Rate
- Graft Rejection
- immunology
- prevention & control
- Humans
- Immunosuppression
- Immunosuppressive Agents
- therapeutic use
- Kidney Transplantation
- immunology
- Male
- Prednisolone
- therapeutic use
- Prospective Studies
- Recombinant Fusion Proteins
- therapeutic use
- Tacrolimus
- therapeutic use
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Webb, Nicholas J ...
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Prokurat, Sylwes ...
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Vondrak, Karel
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Watson, Alan R
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Hughes, David A
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Marks, Stephen D
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visa fler...
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Moghal, Nadeem E
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Fitzpatrick, Mag ...
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Milford, David V
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Saleem, Moin A
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Jones, Caroline ...
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Friman, Styrbjör ...
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Van Damme-Lombae ...
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Janssen, Francoi ...
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Hamer, Clare
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Rhodes, Sarah
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visa färre...
- Artiklar i publikationen
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Pediatric nephro ...
- Av lärosätet
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Göteborgs universitet