Patterns of recurrence of early breast cancer according to estrogen receptor status: a therapeutic target for a quarter of a century.

The current therapeutic strategy in breast cancer is to identify a target, such as estrogen receptor (ER) status, for tailoring treatments. We investigated the patterns of recurrence with respect to ER status for patients treated in two randomized trials with 25 years' median follow-up. In the ER-negative subpopulations most breast cancer events occurred within the first 5-7 years after randomization, while in the ER-positive subpopulations breast cancer events were spread through 10 years. In the ER-positive subpopulation, 1 year endocrine treatment alone significantly prolonged disease-free survival (DFS) with no additional benefit observed by adding 1 year of chemotherapy. In the small ER-negative subpopulation chemo-endocrine therapy had a significantly better DFS than endocrine alone or no treatment. Despite small numbers of patients, "old-fashioned" treatments, and competing causes of treatment failure, the value of ER status as a target for response to adjuvant treatment is evident through prolonged follow-up.

Price, Karen N (author)
Gelber, Richard D (author)
Castiglione-Gertsch, Monica (author)
Holmberg, Stig B,1946Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för kirurgi,Institute of Clinical Sciences, Department of Surgery (author)
Lindtner, Jurij (author)
Thürlimann, Beat (author)
Collins, John (author)
Fey, Martin F (author)
Coates, Alan S (author)
Goldhirsch, Aron (author)
Göteborgs universitetInstitutionen för kliniska vetenskaper, Avdelningen för kirurgi (creator_code:org_t)

In:Breast cancer research and treatment: Springer Science and Business Media LLC117:2, s. 319-241573-72170167-6806

By the author/editor: Pagani, Olivia; Price, Karen N; Gelber, Richard ...; Castiglione-Gert ...; Holmberg, Stig B ...; Lindtner, Jurij; show more...; Thürlimann, Beat; Collins, John; Fey, Martin F; Coates, Alan S; Goldhirsch, Aron; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cancer and Oncol ...

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