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  • Johannesson, MagnusStockholm School of Economics,Handelshögskolan i Stockholm (author)

Genome-wide association meta-analysis of 78,308 individuals identifies new loci and genes influencing human intelligence

  • Article/chapterEnglish2017

Publisher, publication year, extent ...

  • 2017-05-22
  • Nature Research (part of Springer Nature),2017

Numbers

  • LIBRIS-ID:oai:hhs.se:1155078830006056
  • https://research.hhs.se/esploro/outputs/journalArticle/Genome-wide-association-meta-analysis-of-78308-individuals/991001480569906056URI
  • https://doi.org/10.1038/ng.3869DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:136091607URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Intelligence is associated with important economic and health-related life outcomes. Despite intelligence having substantial heritability (0.54) and a confirmed polygenic nature, initial genetic studies were mostly underpowered. Here we report a meta-analysis for intelligence of 78,308 individuals. We identify 336 associated SNPs (METAL P −8) in 18 genomic loci, of which 15 are new. Around half of the SNPs are located inside a gene, implicating 22 genes, of which 11 are new findings. Gene-based analyses identified an additional 30 genes (MAGMA P −6), of which all but one had not been implicated previously. We show that the identified genes are predominantly expressed in brain tissue, and pathway analysis indicates the involvement of genes regulating cell development (MAGMA competitive P = 3.5 × 10−6). Despite the well-known difference in twin-based heritability2 for intelligence in childhood (0.45) and adulthood (0.80), we show substantial genetic correlation (rg = 0.89, LD score regression P = 5.4 × 10−29). These findings provide new insight into the genetic architecture of intelligence.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Cesarini, DavidCenter for Experimental Social Science (author)
  • Koellinger, Philipp D.Erasmus School of Economics (NL) (author)
  • Magnusson, Patrik K. E.Karolinska Institutet,Karolinska Institutet (SE),King's College London (GB) (author)
  • Okbay, AysuErasmus School of Economics (NL) (author)
  • Rietveld, Cornelius A.Erasmus University (NL) (author)
  • Tiemeier, HenningErasmus University (NL) (author)
  • Sniekers, SuzanneVU University (NL) (author)
  • Stringer, SvenVU University (NL) (author)
  • Watanabe, KyokoVU University (NL) (author)
  • Jansen, Phillip R.VU University (NL) (author)
  • Coleman, Jonathan R. I.King's College London (GB) (author)
  • Krapohl, EvaKing's College London (GB) (author)
  • Taskesen, ErdoganVU University (NL) (author)
  • Hammerschlag, Anke R.VU University (NL) (author)
  • Zabaneh, DelilahKing's College London (GB) (author)
  • Amin, NajafErasmus Medical Center (author)
  • Breen, GeromeNational institute of health research (author)
  • Chabris, Christopher F.Union College (US) (author)
  • Iacono, William G.University of Minnesota Twin Cities (US) (author)
  • Ikram, Arfan M.Erasmus Medical Center,University of Minnesota Twin Cities (US) (author)
  • Lee, James J.University of Minnesota Twin Cities (US) (author)
  • McGue, MattUniversity of Minnesota Twin Cities (US),Leiden University (author)
  • Miller, Mike B.University of Minnesota Twin Cities (US) (author)
  • Ollier, William E.R.University of Manchester (GB) (author)
  • Payton, AntonyUniversity of Manchester (GB) (author)
  • Pendleton, NeilUniversity of Manchester (GB) (author)
  • Plomin, RobertKing's College London (GB) (author)
  • van Duijn, Cornerlia M.Leiden University (author)
  • Posthuma, DanielleVU University (NL) (author)
  • Handelshögskolan i StockholmStockholm School of Economics (creator_code:org_t)

Related titles

  • In:Nature Genetics: Nature Research (part of Springer Nature)1061-40361546-1718

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