The burden of osteoporotic fractures : A method for setting intervention thresholds

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Oden, AConsulting Statistician (författare)

The burden of osteoporotic fractures : A method for setting intervention thresholds

Artikel/kapitelEngelska2001

Förlag, utgivningsår, omfång ...

Springer,2001

Nummerbeteckningar

LIBRIS-ID:oai:hhs.se:1162911140006056
https://research.hhs.se/esploro/outputs/journalArticle/The-burden-of-osteoporotic-fractures/991001530698106056URI
https://doi.org/10.1007/s001980170112DOI

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Språk:engelska
Sammanfattning på:engelska

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Ämneskategori:art swepub-publicationtype
Ämneskategori:ref swepub-contenttype

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The aim of this study was to assess the relationship between morbidity from hip fracture and that from other osteoporotic fractures by age and sex based on the population of Sweden. Osteoporotic fractures were designated as those associated with low bone mineral density (BMD) and those that increased in incidence with age after the age of 50 years. Severity of fractures was weighted according to their morbidity using utility values based on those derived by the National Osteoporosis Foundation. Morbidity from fractures other than hip fracture was converted to hip fracture equivalents according to their disutility weights. Excess morbidity was 3.34 and 4.75 in men and women at the age of 50 years, i.e. the morbidity associated with osteoporotic fractures was 3-5 times that accounted for by hip fracture. Excess morbidity decreased with age to approximately 1.25 between the ages of 85 and 89 years. On the assumption that the age- and sex-specific pattern of fractures due to osteoporosis is similar in different communities, the computation of excess morbidity can be utilized to determine the total morbidity from osteoporotic fractures from knowledge of hip fracture rates alone. Such data can be used to weight probabilities of hip fracture in different countries in order to take into account the morbidity from fractures other than hip fracture, and to modify intervention thresholds based on hip fracture risk alone. If, for example, a 10-year probability of hip fracture of 10% was considered an intervention threshold, this would be exceeded in women with osteoporosis aged 65 years and more, but when weighted for other osteoporotic fractures would be exceeded in all women (and men) with osteoporosis.

Ämnesord och genrebeteckningar

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Ortopedi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Orthopaedics hsv//eng

Biuppslag (personer, institutioner, konferenser, titlar ...)

Johnell, OMalmö University (författare)
DE LAET, CInstitute for Medical Technology Assessment (författare)
Jönsson, BengtStockholm School of Economics,Handelshögskolan i Stockholm(Swepub:hhs)211@hhs.se (författare)
Dawson, ALilly Research Centre Ltd (författare)
Kanis, J. AUniversity of Sheffield (författare)
Consulting StatisticianMalmö University (creator_code:org_t)

Sammanhörande titlar

Ingår i:Osteoporosis international: Springer12:5, s. 417-4271433-29650937-941X

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Osteoporosis international (Sök värdpublikationen i LIBRIS)

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Av författaren/redakt...: Oden, A; Johnell, O; DE LAET, C; Jönsson, Bengt; Dawson, A; Kanis, J. A

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Ortopedi

Artiklar i publikationen: Osteoporosis int ...

Av lärosätet: Handelshögskolan i Stockholm

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