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Neurophysiological ...
Neurophysiological treatment effects of mesdopetam, pimavanserin and clozapine in a rodent model of Parkinson's disease psychosis
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- Stan, Tiberiu Loredan (author)
- Lund University,Lunds universitet,Integrativ neurofysiologi,Forskargrupper vid Lunds universitet,Integrative Neurophysiology,Lund University Research Groups,The Group for Integrative Neurophysiology and Neurotechnology, Department of Experimental Medical Science, Lund University, Lund, Sweden
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- Ronaghi, Abdolaziz (author)
- Umeå universitet,Umeå University,Institutionen för medicinsk och translationell biologi
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- Barrientos, Sebastian A (author)
- Lund University,Lunds universitet,Integrativ neurofysiologi,Forskargrupper vid Lunds universitet,Neuronano Research Center (NRC),Integrative Neurophysiology,Lund University Research Groups,The Group for Integrative Neurophysiology and Neurotechnology, Department of Experimental Medical Science, Lund University, Lund, Sweden
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- Halje, Pär (author)
- Lund University,Lunds universitet,Integrativ neurofysiologi,Forskargrupper vid Lunds universitet,Neuronano Research Center (NRC),LU profilområde: Naturlig och artificiell kognition,Lunds universitets profilområden,MoRe-Lab,Institutionen för hälsovetenskaper,Medicinska fakulteten,Integrative Neurophysiology,Lund University Research Groups,LU Profile Area: Natural and Artificial Cognition,Lund University Profile areas,MoRe Lab,Department of Health Sciences,Faculty of Medicine,The Group for Integrative Neurophysiology and Neurotechnology, Department of Experimental Medical Science, Lund University, Lund, Sweden
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- Censoni, Luciano (author)
- Umeå universitet,Umeå University,Institutionen för medicinsk och translationell biologi
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- Garro-Martínez, Emilio (author)
- Umeå universitet,Umeå University,Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM),Institutionen för medicinsk och translationell biologi
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- Nasretdinov, Azat (author)
- Umeå universitet,Umeå University,Institutionen för medicinsk och translationell biologi
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- Malinina, Evgenya (author)
- Umeå universitet,Umeå University,Institutionen för medicinsk och translationell biologi
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- Hjorth, Stephan (author)
- Integrative Research Laboratories Sweden AB, Göteborg, Sweden
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- Svensson, Peder (author)
- Integrative Research Laboratories Sweden AB, Göteborg, Sweden
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- Waters, Susanna (author)
- Integrative Research Laboratories Sweden AB, Göteborg, Sweden
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- Sahlholm, Kristoffer (author)
- Karolinska Institutet,Umeå universitet,Umeå University,Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM),Department of Physiology and Pharmacology, Karolinska Institutet, Solna, Sweden
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- Petersson, Per (author)
- Umeå universitet,Umeå University,Lund University,Lunds universitet,Integrativ neurofysiologi,Forskargrupper vid Lunds universitet,Neuronano Research Center (NRC),LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,LU profilområde: Naturlig och artificiell kognition,Lunds universitets profilområden,Integrative Neurophysiology,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,LU Profile Area: Natural and Artificial Cognition,Lund University Profile areas,Institutionen för medicinsk och translationell biologi,The Group for Integrative Neurophysiology and Neurotechnology, Department of Experimental Medical Science, Lund University, Lund, Sweden
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(creator_code:org_t)
- Elsevier, 2024
- 2024
- English.
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In: Neurotherapeutics. - : Elsevier. - 1878-7479 .- 1933-7213. ; 21:2, s. 1-12
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Abstract
Subject headings
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- Psychosis in Parkinson's disease is a common phenomenon associated with poor outcomes. To clarify the pathophysiology of this condition and the mechanisms of antipsychotic treatments, we have here characterized the neurophysiological brain states induced by clozapine, pimavanserin, and the novel prospective antipsychotic mesdopetam in a rodent model of Parkinson's disease psychosis, based on chronic dopaminergic denervation by 6-OHDA lesions, levodopa priming, and the acute administration of an NMDA antagonist. Parallel recordings of local field potentials from eleven cortical and sub-cortical regions revealed shared neurophysiological treatment effects for the three compounds, despite their different pharmacological profiles, involving reversal of features associated with the psychotomimetic state, such as a reduction of aberrant high-frequency oscillations in prefrontal structures together with a decrease of abnormal synchronization between different brain regions. Other drug-induced neurophysiological features were more specific to each treatment, affecting network oscillation frequencies and entropy, pointing to discrete differences in mechanisms of action. These findings indicate that neurophysiological characterization of brain states is particularly informative when evaluating therapeutic mechanisms in conditions involving symptoms that are difficult to assess in rodents such as psychosis, and that mesdopetam should be further explored as a potential novel antipsychotic treatment option for Parkinson psychosis.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmaceutiska vetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmaceutical Sciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
Keyword
- Animals
- Clozapine/pharmacology
- Parkinson Disease/complications
- Antipsychotic Agents/pharmacology
- Rodentia
- Prospective Studies
- Psychotic Disorders/etiology
- Phenyl Ethers
- Piperidines
- Propylamines
- Urea/analogs & derivatives
- Antipsychotics
Publication and Content Type
- art (subject category)
- ref (subject category)
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Stan, Tiberiu Lo ...
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Ronaghi, Abdolaz ...
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Barrientos, Seba ...
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Halje, Pär
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Censoni, Luciano
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Garro-Martínez, ...
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Nasretdinov, Aza ...
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Malinina, Evgeny ...
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Hjorth, Stephan
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Svensson, Peder
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Waters, Susanna
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Sahlholm, Kristo ...
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Petersson, Per
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MEDICAL AND HEAL ...
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MEDICAL AND HEAL ...
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Neurotherapeutic ...
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Lund University
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Umeå University
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Karolinska Institutet