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  • Mayén, Ana-LuciaInternational Agency for Research on Cancer, World Health Organization (författare)

Dietary intake of advanced glycation endproducts and risk of hepatobiliary cancers : a multinational cohort study

  • Artikel/kapitelEngelska2021

Förlag, utgivningsår, omfång ...

  • 2021-05-06
  • Wiley,2021
  • 11 s.

Nummerbeteckningar

  • LIBRIS-ID:oai:lup.lub.lu.se:0032fda5-bcaa-43c6-b56c-06f17af09aac
  • https://lup.lub.lu.se/record/0032fda5-bcaa-43c6-b56c-06f17af09aacURI
  • https://doi.org/10.1002/ijc.33612DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:art swepub-publicationtype
  • Ämneskategori:ref swepub-contenttype

Anmärkningar

  • Advanced glycation endproducts (AGEs) may contribute to liver carcinogenesis because of their pro-inflammatory and pro-oxidative properties. Diet is a major source of AGEs, but there is sparse human evidence on the role of AGEs intake in liver cancer aetiology. We examined the association between dietary AGEs and the risk of hepatobiliary cancers in the European Prospective Investigation into Cancer and Nutrition prospective cohort (n=450,111). Dietary intake of three AGEs, Nε -[carboxymethyl]lysine (CML), Nε -[1-carboxyethyl]lysine (CEL), and Nδ -[5-hydro-5-methyl-4-imidazolon-2-yl]-ornithine (MG-H1), was estimated using country-specific dietary questionnaires linked to an AGEs database. Cause-specific hazard ratios (HR) and their 95% confidence intervals (CI) for associations between dietary AGEs and risk of hepatocellular carcinoma (HCC), gallbladder, and biliary tract cancers were estimated using multivariable Cox proportional hazard regression. After a median follow-up time of 14.9 years, 255 cases of HCC, 100 cases of gallbladder cancer, and 173 biliary tract cancers were ascertained. Higher intakes of dietary AGEs were inversely associated with risk of HCC (per 1 standard deviation [SD] increment, HR-CML =0.87, 95% CI: 0.76 to 0.99, HR-CEL =0.84, 95% CI: 0.74 to 0.96, and HR-MH-G1 = 0.84, 95% CI: 0.74 to 0.97). In contrast, positive associations were observed with risk of gallbladder cancer (per 1 SD, HR-CML =1.28, 95% CI: 1.05 to 1.56, HR-CEL =1.17; 95% CI: 0.96 to 1.40, HR-MH-G1 =1.27, 95% CI: 1.06 to 1.54). No associations were observed for cancers of the intra- and extra-hepatic bile ducts. Our findings suggest that higher intakes of dietary AGEs are inversely associated with the risk of HCC and positively associated with the risk of gallbladder cancer.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Aglago, Elom KInternational Agency for Research on Cancer, World Health Organization (författare)
  • Knaze, ViktoriaInternational Agency for Research on Cancer, World Health Organization (författare)
  • Cordova, ReynaldaWebster Vienna Private University (författare)
  • Schalkwijk, Casper GMaastricht University Medical Centre (författare)
  • Wagner, Karl-HeinzWebster Vienna Private University (författare)
  • Aleksandrova, KrasimiraGerman Institute of Human Nutrition (författare)
  • Fedirko, VeronikaEmory University (författare)
  • Keski-Rahkonen, PekkaInternational Agency for Research on Cancer, World Health Organization (författare)
  • Leitzmann, Michael FUniversity Hospital Regensburg (författare)
  • Katzke, VerenaGerman Cancer Research Centre (författare)
  • Srour, BernardGerman Cancer Research Centre (författare)
  • Schulze, Matthias BGerman Institute of Human Nutrition (författare)
  • Masala, GiovannaBeatson Institute for Cancer Research (författare)
  • Krogh, Vittorio (författare)
  • Panico, SalvatoreUniversity of Naples Federico II (författare)
  • Tumino, Rosario (författare)
  • Bueno-de-Mesquita, BasNational Institute for Public Health and the Environment (RIVM) (författare)
  • Brustad, MagrittUiT The Arctic University of Norway, Tromsø (författare)
  • Agudo, AntonioCatalan Institute of Oncology-Girona (författare)
  • Chirlaque López, María DoloresShanghai Cancer Institute (författare)
  • Amiano, PilarBiodonostia Health Research Institute (författare)
  • Ohlsson, BodilLund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups,Skåne University Hospital(Swepub:lu)kir-boh (författare)
  • Ramne, StinaLund University,Lunds universitet,Nutritionsepidemiologi,Forskargrupper vid Lunds universitet,Nutrition Epidemiology,Lund University Research Groups(Swepub:lu)st1854ra (författare)
  • Aune, DagfinnImperial College London (författare)
  • Weiderpass, ElisabeteInternational Agency for Research on Cancer, World Health Organization (författare)
  • Jenab, MazdaInternational Agency for Research on Cancer, World Health Organization (författare)
  • Freisling, HeinzInternational Agency for Research on Cancer, World Health Organization (författare)
  • International Agency for Research on Cancer, World Health OrganizationWebster Vienna Private University (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:International Journal of Cancer: Wiley149:4, s. 854-8640020-71361097-0215

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