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Clinically relevant...
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Dubnika Hauksson, IneseLund University,Lunds universitet,Yrkes- och miljödermatologi,Forskargrupper vid Lunds universitet,Occupational and Environmental Dermatology,Lund University Research Groups
(författare)
Clinically relevant contact allergy to formaldehyde may be missed by testing with formaldehyde 1.0%.
- Artikel/kapitelEngelska2011
Förlag, utgivningsår, omfång ...
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2011-02-03
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Oxford University Press (OUP),2011
Nummerbeteckningar
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LIBRIS-ID:oai:lup.lub.lu.se:00684d9e-86ac-470e-a243-ca57c23f74c3
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https://lup.lub.lu.se/record/1757038URI
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https://doi.org/10.1111/j.1365-2133.2010.10151.xDOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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Ämneskategori:ref swepub-contenttype
Anmärkningar
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Background: It has been found that patch testing with 15μl formaldehyde 2.0% aq detects twice more allergies than testing with 1.0%. The clinical relevance of positive patch test reactions is often difficult to determine. Use tests are simple to do and help to evaluate the significance of patch test results. Objectives: To study the clinical relevance of contact allergy to formaldehyde detected by 2.0% (0.60 mg/cm²) but not by 1.0%. Patients/Methods: 18 patients positive to formaldehyde 2.0% but negative to 1.0% and a control group of 19 dermatitis patients without allergy to parabens, formaldehyde and formaldehyde releasers were included in the study. Formaldehyde 2000 ppm, the maximum concentration permitted in leave-on cosmetics according to the EU Cosmetics Directive, was added to a batch of a moisturiser preserved with parabens. The same batch without formaldehyde served as control. The study was double-blinded and randomised. The patients were provided with both moisturisers and instructed to apply one of them twice a day on a marked-out 5×5 cm area on the inside of one upper arm and the other moisturiser on the other arm. Reading of the test sites was done once a week for a maximum of 4 weeks. Results: In the control group there were no allergic reactions to any of the moisturisers. 9 of the 17 formaldehyde-allergic patients reacted with an allergic reaction to the moisturiser which contained formaldehyde (p<0.001). No positive reactions were observed to the moisturiser without formaldehyde. Conclusions: Our results demonstrate that contact allergy to formaldehyde 2.0% may be clinically relevant.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Pontén, AnnLund University,Lunds universitet,Yrkes- och miljödermatologi,Forskargrupper vid Lunds universitet,Occupational and Environmental Dermatology,Lund University Research Groups(Swepub:lu)derm-apo
(författare)
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Gruvberger, BirgittaLund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine(Swepub:lu)derm-bgr
(författare)
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Isaksson, MarléneLund University,Lunds universitet,Yrkes- och miljödermatologi,Forskargrupper vid Lunds universitet,Occupational and Environmental Dermatology,Lund University Research Groups(Swepub:lu)derm-mis
(författare)
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Bruze, MagnusLund University,Lunds universitet,Yrkes- och miljödermatologi,Forskargrupper vid Lunds universitet,Occupational and Environmental Dermatology,Lund University Research Groups(Swepub:lu)derm-mbr
(författare)
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Yrkes- och miljödermatologiForskargrupper vid Lunds universitet
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:British Journal of Dermatology: Oxford University Press (OUP)164:3, s. 568-5721365-21330007-0963
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