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- Nystrom, TKarolinska Institutet (author)
Effects of glucagon-like peptide-1 on endothelial function in type 2 diabetes patients with stable coronary artery disease
- Article/chapterEnglish2004
Publisher, publication year, extent ...
- American Physiological Society,2004
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- LIBRIS-ID:oai:lup.lub.lu.se:00af0c4d-4158-46d9-afb0-ef363eea4ef9
- https://lup.lub.lu.se/record/262585URI
- https://doi.org/10.1152/ajpendo.00237.2004DOI
- http://kipublications.ki.se/Default.aspx?queryparsed=id:1939343URI
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- Language:English
- Summary in:English
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Notes
- GLP-1 stimulates insulin secretion, suppresses glucagon secretion, delays gastric emptying, and inhibits small bowel motility, all actions contributing to the anti-diabetogenic peptide effect. Endothelial dysfunction is strongly associated with insulin resistance and type 2 diabetes mellitus and may cause the angiopathy typifying this debilitating disease. Therefore, interventions affecting both endothelial dysfunction and insulin resistance may prove useful in improving survival in type 2 diabetes patients. We investigated GLP-1's effect on endothelial function and insulin sensitivity (S-I) in two groups: 1) 12 type 2 diabetes patients with stable coronary artery disease and 2) 10 healthy subjects with normal endothelial function and S-I. Subjects underwent infusion of recombinant GLP-1 or saline in a random crossover study. Endothelial function was measured by postischemic FMD of brachial artery, using ultrasonography. S-I [in (10(-4) dl.kg(-1).min(-1))/(muU/ml)] was measured by hyperinsulinemic isoglycemic clamp technique. In type 2 diabetic subjects, GLP-1 infusion significantly increased relative changes in brachial artery diameter from baseline FMD(%) (3.1 +/- 0.6 vs. 6.6 +/- 1.0%, P < 0.05), with no significant effects on S-I (4.5 &PLUSMN; 0.8 vs. 5.2 &PLUSMN; 0.9, P = NS). In healthy subjects, GLP-1 infusion affected neither FMD(%) (11.9 &PLUSMN; 0.9 vs. 10.3 &PLUSMN; 1.0%, P = NS) nor S-I (14.8 &PLUSMN; 1.8 vs. 11.6 &PLUSMN; 2.0, P = NS). We conclude that GLP-1 improves endothelial dysfunction but not insulin resistance in type 2 diabetic patients with coronary heart disease. This beneficial vascular effect of GLP-1 adds yet another salutary property of the peptide useful in diabetes treatment.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Fysiologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Physiology hsv//eng
- nitric oxide
- insulin resistance
Added entries (persons, corporate bodies, meetings, titles ...)
- Gutniak, MK (author)
- Zhang, QMKarolinska Institutet (author)
- Zhang, FKarolinska Institutet (author)
- Holst, JJ (author)
- Ahrén, BoLund University,Lunds universitet,Medicin, Lund,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medicine, Lund,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)med-bah (author)
- Sjoholm, AKarolinska Institutet (author)
- Karolinska InstitutetMedicin, Lund (creator_code:org_t)
Related titles
- In:American Journal of Physiology: Endocrinology and Metabolism: American Physiological Society287:6, s. 1209-12151522-15550193-1849
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