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  • Joura, Elmar A. (author)

HPV antibody levels and clinical efficacy following administration of a prophylactic quadrivalent HPV vaccine

  • Article/chapterEnglish2008

Publisher, publication year, extent ...

  • Elsevier BV,2008

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:00c798d7-5686-4a46-98dc-aee56f4db5cb
  • https://lup.lub.lu.se/record/1376300URI
  • https://doi.org/10.1016/j.vaccine.2008.09.073DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:118062132URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • The efficacy of the quadrivalent Human Papillomavirus (HPV) vaccine is thought to be mediated by humoral immunity. We evaluated the correlation between quadrivalent HPV vaccine-induced serum anti-HPV responses and efficacy. 17,622 women were vaccinated at day 1, and months 2 and 6. At day I and at 6-12 months intervals for up to 48 months, subjects underwent Papanicolaou and genital HPV testing. No immune correlate of protection could be found due to low number of cases. Although 40% of vaccine subjects were anti-HPV 18 seronegative at end-of-study, efficacy against HPV 18-related disease remained high (98.4%; 95% CI: 90.5-100.0) despite high attack rates in the placebo group. These results suggest vaccine-induced protection via immune memory, or lower than detectable HPV 18 antibody titers. (C) 2008 Elsevier Ltd. All rights reserved.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Kjaer, Susanne K. (author)
  • Wheeler, Cosette M. (author)
  • Sigurdsson, Kristjan (author)
  • Iversene, Ole-Erik (author)
  • Hernandez-Avila, Mauricio (author)
  • Perez, Gonzalo (author)
  • Brown, Darron R. (author)
  • Koutsky, Laura A. (author)
  • Tay, Eng Hseon (author)
  • Garcia, Patricia (author)
  • Ault, Kevin A. (author)
  • Garland, Suzanne M. (author)
  • Leodolter, Sepp (author)
  • Olssonn, Sven-Eric (author)
  • Tang, Grace W. K. (author)
  • Ferris, Daron G. (author)
  • Paavonen, Jorma (author)
  • Lehtinen, Matti (author)
  • Steben, Marc (author)
  • Bosch, Xavier (author)
  • Dillner, JoakimKarolinska Institutet,Lund University,Lunds universitet,Klinisk mikrobiologi, Malmö,Forskargrupper vid Lunds universitet,Clinical Microbiology, Malmö,Lund University Research Groups(Swepub:lu)mikr-jdi (author)
  • Kurmanv, Robert J. (author)
  • Majewski, Slawomir (author)
  • Munoz, Nubia (author)
  • Myers, Evan R. (author)
  • Villa, Luisa L. (author)
  • Taddeo, Frank J. (author)
  • Roberts, Christine (author)
  • Tadesse, Amha (author)
  • Bryan, Janine (author)
  • Lupinaccia, Lisa C. (author)
  • Giacoletti, Katherine E. D. (author)
  • Lu, Shuang (author)
  • Vuocolo, Scott (author)
  • Hesley, Teresa M. (author)
  • Haupt, Richard M. (author)
  • Barr, Eliav (author)
  • Klinisk mikrobiologi, MalmöForskargrupper vid Lunds universitet (creator_code:org_t)

Related titles

  • In:Vaccine: Elsevier BV26:52, s. 6844-68511873-25180264-410X

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  • Vaccine (Search for host publication in LIBRIS)

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