Search: (WFRF:(Palmer Colin N. A.)) srt2:(2007-2009) >
Meta-analysis of ge...
-
Zeggini, Eleftheria
(author)
Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes
- Article/chapterEnglish2008
Publisher, publication year, extent ...
-
2008-03-30
-
Springer Science and Business Media LLC,2008
Numbers
-
LIBRIS-ID:oai:lup.lub.lu.se:00e89a10-7f60-4524-a7d1-d2ac0ae49eeb
-
https://lup.lub.lu.se/record/1205141URI
-
https://doi.org/10.1038/ng.120DOI
Supplementary language notes
-
Language:English
-
Summary in:English
Part of subdatabase
Classification
-
Subject category:art swepub-publicationtype
-
Subject category:ref swepub-contenttype
Notes
-
Genome-wide association (GWA) studies have identified multiple loci at which common variants modestly but reproducibly influence risk of type 2 diabetes (T2D)(1-11). Established associations to common and rare variants explain only a small proportion of the heritability of T2D. As previously published analyses had limited power to identify variants with modest effects, we carried out meta-analysis of three T2D GWA scans comprising 10,128 individuals of European descent and similar to 2.2 million SNPs (directly genotyped and imputed), followed by replication testing in an independent sample with an effective sample size of up to 53,975. We detected at least six previously unknown loci with robust evidence for association, including the JAZF1 (P=5.0 x 10(-14)), CDC123-CAMK1D (P=1.2 x 10(-10)), TSPAN8-LGR5 (P=1.1 x 10(-9)), THADA (P=1.1 x 10(-9)), ADAMTS9 (P=1.2 x 10(-8)) and NOTCH2 (P=4.1 x 10(-8)) gene regions. Our results illustrate the value of large discovery and follow-up samples for gaining further insights into the inherited basis of T2D.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
-
Scott, Laura J.
(author)
-
Saxena, Richa
(author)
-
Voight, Benjamin F.
(author)
-
Marchini, Jonathan L.
(author)
-
Hu, Tianle
(author)
-
de Bakker, Paul I. W.
(author)
-
Abecasis, Goncalo R.
(author)
-
Almgren, PeterLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups(Swepub:lu)endo-pal
(author)
-
Andersen, Gitte
(author)
-
Ardlie, Kristin
(author)
-
Bostroem, Kristina Bengtsson
(author)
-
Bergman, Richard N.
(author)
-
Bonnycastle, Lori L.
(author)
-
Borch-Johnsen, Knut
(author)
-
Burtt, Noel P.
(author)
-
Chen, Hong
(author)
-
Chines, Peter S.
(author)
-
Daly, Mark J.
(author)
-
Deodhar, Parimal
(author)
-
Ding, Chia-Jen
(author)
-
Doney, Alex S. F.
(author)
-
Duren, William L.
(author)
-
Elliott, Katherine S.
(author)
-
Erdos, Michael R.
(author)
-
Frayling, Timothy M.
(author)
-
Freathy, Rachel M.
(author)
-
Gianniny, Lauren
(author)
-
Grallert, Harald
(author)
-
Grarup, Niels
(author)
-
Groves, Christopher J.
(author)
-
Guiducci, Candace
(author)
-
Hansen, Torben
(author)
-
Herder, Christian
(author)
-
Hitman, Graham A.
(author)
-
Hughes, Thomas E.
(author)
-
Isomaa, Bo
(author)
-
Jackson, Anne U.
(author)
-
Jorgensen, Torben
(author)
-
Kong, Augustine
(author)
-
Kubalanza, Kari
(author)
-
Kuruvilla, Finny G.
(author)
-
Kuusisto, Johanna
(author)
-
Langenberg, Claudia
(author)
-
Lango, Hana
(author)
-
Lauritzen, Torsten
(author)
-
Li, Yun
(author)
-
Lindgren, Cecilia M.
(author)
-
Lyssenko, ValeriyaLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups(Swepub:lu)endo-vly
(author)
-
Marvelle, Amanda F.
(author)
-
Meisinger, Christa
(author)
-
Midthjell, Kristian
(author)
-
Mohlke, Karen L.
(author)
-
Morken, Mario A.
(author)
-
Morris, Andrew D.
(author)
-
Narisu, Narisu
(author)
-
Nilsson, Peter
(author)
-
Owen, Katharine R.
(author)
-
Palmer, Colin N. A.
(author)
-
Payne, Felicity
(author)
-
Perry, John R. B.
(author)
-
Pettersen, Elin
(author)
-
Platou, Carl
(author)
-
Prokopenko, Inga
(author)
-
Qi, Lu
(author)
-
Qin, Li
(author)
-
Rayner, Nigel W.
(author)
-
Rees, Matthew
(author)
-
Roix, Jeffrey J.
(author)
-
Sandbaek, Anelli
(author)
-
Shields, Beverley
(author)
-
Sjögren, MarketaLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups(Swepub:lu)endo-msj
(author)
-
Steinthorsdottir, Valgerdur
(author)
-
Stringham, Heather M.
(author)
-
Swift, Amy J.
(author)
-
Thorleifsson, Gudmar
(author)
-
Thorsteinsdottir, Unnur
(author)
-
Timpson, Nicholas J.
(author)
-
Tuomi, Tiinamaija
(author)
-
Tuomilehto, Jaakko
(author)
-
Walker, Mark
(author)
-
Watanabe, Richard M.
(author)
-
Weedon, Michael N.
(author)
-
Willer, Cristen J.
(author)
-
Illig, Thomas
(author)
-
Hveem, Kristian
(author)
-
Hu, Frank B.
(author)
-
Laakso, Markku
(author)
-
Stefansson, Kari
(author)
-
Pedersen, Oluf
(author)
-
Wareham, Nicholas J.
(author)
-
Barroso, Ines
(author)
-
Hattersley, Andrew T.
(author)
-
Collins, Francis S.
(author)
-
Groop, LeifLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups(Swepub:lu)endo-lgr
(author)
-
McCarthy, Mark I.
(author)
-
Boehnke, Michael
(author)
-
Altshuler, David
(author)
-
Genomik, diabetes och endokrinologiForskargrupper vid Lunds universitet
(creator_code:org_t)
Related titles
-
In:Nature Genetics: Springer Science and Business Media LLC40:5, s. 638-6451546-17181061-4036
Internet link
Find in a library
To the university's database
- By the author/editor
-
Zeggini, Elefthe ...
-
Scott, Laura J.
-
Saxena, Richa
-
Voight, Benjamin ...
-
Marchini, Jonath ...
-
Hu, Tianle
-
show more...
-
de Bakker, Paul ...
-
Abecasis, Goncal ...
-
Almgren, Peter
-
Andersen, Gitte
-
Ardlie, Kristin
-
Bostroem, Kristi ...
-
Bergman, Richard ...
-
Bonnycastle, Lor ...
-
Borch-Johnsen, K ...
-
Burtt, Noel P.
-
Chen, Hong
-
Chines, Peter S.
-
Daly, Mark J.
-
Deodhar, Parimal
-
Ding, Chia-Jen
-
Doney, Alex S. F ...
-
Duren, William L ...
-
Elliott, Katheri ...
-
Erdos, Michael R ...
-
Frayling, Timoth ...
-
Freathy, Rachel ...
-
Gianniny, Lauren
-
Grallert, Harald
-
Grarup, Niels
-
Groves, Christop ...
-
Guiducci, Candac ...
-
Hansen, Torben
-
Herder, Christia ...
-
Hitman, Graham A ...
-
Hughes, Thomas E ...
-
Isomaa, Bo
-
Jackson, Anne U.
-
Jorgensen, Torbe ...
-
Kong, Augustine
-
Kubalanza, Kari
-
Kuruvilla, Finny ...
-
Kuusisto, Johann ...
-
Langenberg, Clau ...
-
Lango, Hana
-
Lauritzen, Torst ...
-
Li, Yun
-
Lindgren, Cecili ...
-
Lyssenko, Valeri ...
-
Marvelle, Amanda ...
-
Meisinger, Chris ...
-
Midthjell, Krist ...
-
Mohlke, Karen L.
-
Morken, Mario A.
-
Morris, Andrew D ...
-
Narisu, Narisu
-
Nilsson, Peter
-
Owen, Katharine ...
-
Palmer, Colin N. ...
-
Payne, Felicity
-
Perry, John R. B ...
-
Pettersen, Elin
-
Platou, Carl
-
Prokopenko, Inga
-
Qi, Lu
-
Qin, Li
-
Rayner, Nigel W.
-
Rees, Matthew
-
Roix, Jeffrey J.
-
Sandbaek, Anelli
-
Shields, Beverle ...
-
Sjögren, Marketa
-
Steinthorsdottir ...
-
Stringham, Heath ...
-
Swift, Amy J.
-
Thorleifsson, Gu ...
-
Thorsteinsdottir ...
-
Timpson, Nichola ...
-
Tuomi, Tiinamaij ...
-
Tuomilehto, Jaak ...
-
Walker, Mark
-
Watanabe, Richar ...
-
Weedon, Michael ...
-
Willer, Cristen ...
-
Illig, Thomas
-
Hveem, Kristian
-
Hu, Frank B.
-
Laakso, Markku
-
Stefansson, Kari
-
Pedersen, Oluf
-
Wareham, Nichola ...
-
Barroso, Ines
-
Hattersley, Andr ...
-
Collins, Francis ...
-
Groop, Leif
-
McCarthy, Mark I ...
-
Boehnke, Michael
-
Altshuler, David
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Endocrinology an ...
- Articles in the publication
-
Nature Genetics
- By the university
-
Lund University