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Meta-analysis of ge...
Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes
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Zeggini, Eleftheria (author)
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Scott, Laura J. (author)
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Saxena, Richa (author)
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show more...
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Voight, Benjamin F. (author)
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Marchini, Jonathan L. (author)
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Hu, Tianle (author)
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de Bakker, Paul I. W. (author)
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Abecasis, Goncalo R. (author)
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- Almgren, Peter (author)
- Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups
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Andersen, Gitte (author)
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Ardlie, Kristin (author)
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Bostroem, Kristina Bengtsson (author)
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Bergman, Richard N. (author)
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Bonnycastle, Lori L. (author)
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Borch-Johnsen, Knut (author)
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Burtt, Noel P. (author)
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Chen, Hong (author)
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Chines, Peter S. (author)
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Daly, Mark J. (author)
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Deodhar, Parimal (author)
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Ding, Chia-Jen (author)
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Doney, Alex S. F. (author)
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Duren, William L. (author)
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Elliott, Katherine S. (author)
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Erdos, Michael R. (author)
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Frayling, Timothy M. (author)
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Freathy, Rachel M. (author)
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Gianniny, Lauren (author)
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Grallert, Harald (author)
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Grarup, Niels (author)
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Groves, Christopher J. (author)
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Guiducci, Candace (author)
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Hansen, Torben (author)
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Herder, Christian (author)
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Hitman, Graham A. (author)
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Hughes, Thomas E. (author)
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Isomaa, Bo (author)
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Jackson, Anne U. (author)
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Jorgensen, Torben (author)
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Kong, Augustine (author)
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Kubalanza, Kari (author)
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Kuruvilla, Finny G. (author)
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Kuusisto, Johanna (author)
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Langenberg, Claudia (author)
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Lango, Hana (author)
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Lauritzen, Torsten (author)
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Li, Yun (author)
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Lindgren, Cecilia M. (author)
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- Lyssenko, Valeriya (author)
- Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups
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Marvelle, Amanda F. (author)
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Meisinger, Christa (author)
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Midthjell, Kristian (author)
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Mohlke, Karen L. (author)
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Morken, Mario A. (author)
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Morris, Andrew D. (author)
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Narisu, Narisu (author)
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Nilsson, Peter (author)
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Owen, Katharine R. (author)
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Palmer, Colin N. A. (author)
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Payne, Felicity (author)
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Perry, John R. B. (author)
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Pettersen, Elin (author)
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Platou, Carl (author)
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Prokopenko, Inga (author)
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Qi, Lu (author)
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Qin, Li (author)
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Rayner, Nigel W. (author)
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Rees, Matthew (author)
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Roix, Jeffrey J. (author)
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Sandbaek, Anelli (author)
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Shields, Beverley (author)
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- Sjögren, Marketa (author)
- Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups
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Steinthorsdottir, Valgerdur (author)
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Stringham, Heather M. (author)
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Swift, Amy J. (author)
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Thorleifsson, Gudmar (author)
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Thorsteinsdottir, Unnur (author)
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Timpson, Nicholas J. (author)
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Tuomi, Tiinamaija (author)
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Tuomilehto, Jaakko (author)
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Walker, Mark (author)
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Watanabe, Richard M. (author)
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Weedon, Michael N. (author)
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Willer, Cristen J. (author)
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Illig, Thomas (author)
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Hveem, Kristian (author)
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Hu, Frank B. (author)
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Laakso, Markku (author)
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Stefansson, Kari (author)
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Pedersen, Oluf (author)
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Wareham, Nicholas J. (author)
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Barroso, Ines (author)
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Hattersley, Andrew T. (author)
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Collins, Francis S. (author)
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- Groop, Leif (author)
- Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups
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McCarthy, Mark I. (author)
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Boehnke, Michael (author)
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Altshuler, David (author)
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(creator_code:org_t)
- 2008-03-30
- 2008
- English.
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In: Nature Genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 40:5, s. 638-645
- Related links:
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http://dx.doi.org/10...
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https://europepmc.or...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Genome-wide association (GWA) studies have identified multiple loci at which common variants modestly but reproducibly influence risk of type 2 diabetes (T2D)(1-11). Established associations to common and rare variants explain only a small proportion of the heritability of T2D. As previously published analyses had limited power to identify variants with modest effects, we carried out meta-analysis of three T2D GWA scans comprising 10,128 individuals of European descent and similar to 2.2 million SNPs (directly genotyped and imputed), followed by replication testing in an independent sample with an effective sample size of up to 53,975. We detected at least six previously unknown loci with robust evidence for association, including the JAZF1 (P=5.0 x 10(-14)), CDC123-CAMK1D (P=1.2 x 10(-10)), TSPAN8-LGR5 (P=1.1 x 10(-9)), THADA (P=1.1 x 10(-9)), ADAMTS9 (P=1.2 x 10(-8)) and NOTCH2 (P=4.1 x 10(-8)) gene regions. Our results illustrate the value of large discovery and follow-up samples for gaining further insights into the inherited basis of T2D.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Zeggini, Elefthe ...
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Scott, Laura J.
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Saxena, Richa
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Voight, Benjamin ...
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Marchini, Jonath ...
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Hu, Tianle
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show more...
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de Bakker, Paul ...
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Abecasis, Goncal ...
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Almgren, Peter
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Andersen, Gitte
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Ardlie, Kristin
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Bostroem, Kristi ...
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Bergman, Richard ...
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Bonnycastle, Lor ...
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Borch-Johnsen, K ...
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Burtt, Noel P.
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Chen, Hong
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Chines, Peter S.
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Daly, Mark J.
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Deodhar, Parimal
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Ding, Chia-Jen
-
Doney, Alex S. F ...
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Duren, William L ...
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Elliott, Katheri ...
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Erdos, Michael R ...
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Frayling, Timoth ...
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Freathy, Rachel ...
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Gianniny, Lauren
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Grallert, Harald
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Grarup, Niels
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Groves, Christop ...
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Guiducci, Candac ...
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Hansen, Torben
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Herder, Christia ...
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Hitman, Graham A ...
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Hughes, Thomas E ...
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Isomaa, Bo
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Jackson, Anne U.
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Jorgensen, Torbe ...
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Kong, Augustine
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Kubalanza, Kari
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Kuruvilla, Finny ...
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Kuusisto, Johann ...
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Langenberg, Clau ...
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Lango, Hana
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Lauritzen, Torst ...
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Li, Yun
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Lindgren, Cecili ...
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Lyssenko, Valeri ...
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Marvelle, Amanda ...
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Meisinger, Chris ...
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Midthjell, Krist ...
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Mohlke, Karen L.
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Morken, Mario A.
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Morris, Andrew D ...
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Narisu, Narisu
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Nilsson, Peter
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Owen, Katharine ...
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Palmer, Colin N. ...
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Payne, Felicity
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Perry, John R. B ...
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Pettersen, Elin
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Platou, Carl
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Prokopenko, Inga
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Qi, Lu
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Qin, Li
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Rayner, Nigel W.
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Rees, Matthew
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Roix, Jeffrey J.
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Sandbaek, Anelli
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Shields, Beverle ...
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Sjögren, Marketa
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Steinthorsdottir ...
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Stringham, Heath ...
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Swift, Amy J.
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Thorleifsson, Gu ...
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Thorsteinsdottir ...
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Timpson, Nichola ...
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Tuomi, Tiinamaij ...
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Tuomilehto, Jaak ...
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Walker, Mark
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Watanabe, Richar ...
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Weedon, Michael ...
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Willer, Cristen ...
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Illig, Thomas
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Hveem, Kristian
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Hu, Frank B.
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Laakso, Markku
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Stefansson, Kari
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Pedersen, Oluf
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Wareham, Nichola ...
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Barroso, Ines
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Hattersley, Andr ...
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Collins, Francis ...
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Groop, Leif
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McCarthy, Mark I ...
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Boehnke, Michael
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Altshuler, David
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
- Articles in the publication
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Nature Genetics
- By the university
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Lund University