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Circulating Metabol...
Circulating Metabolomic and Lipidomic Signatures Identify a Type 2 Diabetes Risk Profile in Low-Birth-Weight Men with Non-Alcoholic Fatty Liver Disease
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- Elingaard-Larsen, Line O. (författare)
- Steno Diabetes Center Copenhagen
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- Villumsen, Sofie O. (författare)
- Steno Diabetes Center Copenhagen
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- Justesen, Louise (författare)
- Steno Diabetes Center Copenhagen
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- Thuesen, Anne Cathrine B. (författare)
- University of Copenhagen,Novo Nordisk Foundation Centre for Basic Metabolic Research
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- Kim, Min (författare)
- Steno Diabetes Center Copenhagen
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- Ali, Mina (författare)
- Steno Diabetes Center Copenhagen
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- Danielsen, Else R. (författare)
- Copenhagen University Hospital
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- Legido-Quigley, Cristina (författare)
- Steno Diabetes Center Copenhagen
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- van Hall, Gerrit (författare)
- Copenhagen University Hospital,University of Copenhagen
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- Hansen, Torben (författare)
- Novo Nordisk Foundation Centre for Basic Metabolic Research,University of Copenhagen
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- Ahluwalia, Tarunveer S. (författare)
- Steno Diabetes Center Copenhagen,University of Copenhagen
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- Vaag, Allan A. (författare)
- Lund University,Lunds universitet,-lup-obsolete,Forskargrupper vid Lunds universitet,LUDC (Lund University Diabetes Centre)-lup-obsolete,Lund University Research Groups,Steno Diabetes Center Copenhagen
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- Brøns, Charlotte (författare)
- Steno Diabetes Center Copenhagen
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(creator_code:org_t)
- 2023-03-24
- 2023
- Engelska.
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Ingår i: Nutrients. - : MDPI AG. - 2072-6643. ; 15:7
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- The extent to which increased liver fat content influences differences in circulating metabolites and/or lipids between low-birth-weight (LBW) individuals, at increased risk of type 2 diabetes (T2D), and normal-birth-weight (NBW) controls is unknown. The objective of the study was to perform untargeted serum metabolomics and lipidomics analyses in 26 healthy, non-obese early-middle-aged LBW men, including five men with screen-detected and previously unrecognized non-alcoholic fatty liver disease (NAFLD), compared with 22 age- and BMI-matched NBW men (controls). While four metabolites (out of 65) and fifteen lipids (out of 279) differentiated the 26 LBW men from the 22 NBW controls (p ≤ 0.05), subgroup analyses of the LBW men with and without NAFLD revealed more pronounced differences, with 11 metabolites and 56 lipids differentiating (p ≤ 0.05) the groups. The differences in the LBW men with NAFLD included increased levels of ornithine and tyrosine (PFDR ≤ 0.1), as well as of triglycerides and phosphatidylcholines with shorter carbon-chain lengths and fewer double bonds. Pathway and network analyses demonstrated downregulation of transfer RNA (tRNA) charging, altered urea cycling, insulin resistance, and an increased risk of T2D in the LBW men with NAFLD. Our findings highlight the importance of increased liver fat in the pathogenesis of T2D in LBW individuals.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Nyckelord
- lipidomics
- liver fat
- low-birth-weight
- metabolomics
- non-alcoholic fatty liver disease
- type 2 diabetes
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Elingaard-Larsen ...
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Villumsen, Sofie ...
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Justesen, Louise
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Thuesen, Anne Ca ...
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Kim, Min
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Ali, Mina
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Danielsen, Else ...
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Legido-Quigley, ...
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van Hall, Gerrit
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Hansen, Torben
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Ahluwalia, Tarun ...
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Vaag, Allan A.
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Brøns, Charlotte
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