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  • Chubb, Daniel (author)

Common variation at 3q26.2, 6p21.33, 17p11.2 and 22q13.1 influences multiple myeloma risk

  • Article/chapterEnglish2013

Publisher, publication year, extent ...

  • 2013-08-18
  • Springer Science and Business Media LLC,2013

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:0130c0d9-1d4a-48b1-86f1-1f9070f7de4e
  • https://lup.lub.lu.se/record/4172070URI
  • https://doi.org/10.1038/ng.2733DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • To identify variants for multiple myeloma risk, we conducted a genome-wide association study with validation in additional series totaling 4,692 individuals with multiple myeloma (cases) and 10,990 controls. We identified four risk loci at 3q26.2 (rs10936599, P = 8.70 x 10(-14)), 6p21.33 (rs2285803, PSORS1C2, P = 9.67 x 10(-11)), 17p11.2 (rs4273077, TNFRSF13B, P = 7.67 x 10(-9)) and 22q13.1 (rs877529, CBX7, P = 7.63 x 10(-16)). These data provide further evidence for genetic susceptibility to this B-cell hematological malignancy, as well as insight into the biological basis of predisposition.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Weinhold, Niels (author)
  • Broderick, Peter (author)
  • Chen, Bowang (author)
  • Johnson, David C. (author)
  • Försti, AstaLund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Family Medicine and Clinical Epidemiology,Lund University Research Groups(Swepub:lu)med-asf (author)
  • Vijayakrishnan, Jayaram (author)
  • Migliorini, Gabriele (author)
  • Dobbins, Sara E. (author)
  • Holroyd, Amy (author)
  • Hose, Dirk (author)
  • Walker, Brian A. (author)
  • Davies, Faith E. (author)
  • Gregory, Walter A. (author)
  • Jackson, Graham H. (author)
  • Irving, Julie A. (author)
  • Pratt, Guy (author)
  • Fegan, Chris (author)
  • Fenton, James A. L. (author)
  • Neben, Kai (author)
  • Hoffmann, Per (author)
  • Noethen, Markus M. (author)
  • Muehleisen, Thomas W. (author)
  • Eisele, Lewin (author)
  • Ross, Fiona M. (author)
  • Straka, Christian (author)
  • Einsele, Hermann (author)
  • Langer, Christian (author)
  • Doerner, Elisabeth (author)
  • Allan, James M. (author)
  • Jauch, Anna (author)
  • Morgan, Gareth J. (author)
  • Hemminki, Kari (author)
  • Houlston, Richard S. (author)
  • Goldschmidt, Hartmut (author)
  • Allmänmedicin och klinisk epidemiologiForskargrupper vid Lunds universitet (creator_code:org_t)

Related titles

  • In:Nature Genetics: Springer Science and Business Media LLC45:10, s. 366-12211546-17181061-4036

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