WFRF:(Nygren David)
Sökning: WFRF:(Nygren David) > (2020-2024) > Size distribution o...
Size distribution of exhaled aerosol particles containing SARS-CoV-2 RNA
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- Alsved, Malin (författare)
- Lund University,Lunds universitet,Metalund,Annan verksamhet, LTH,Lunds Tekniska Högskola,NanoLund: Centre for Nanoscience,Annan verksamhet, LTH,Ergonomi och aerosolteknologi,Institutionen för designvetenskaper,Institutioner vid LTH,LTH profilområde: Aerosoler,LTH profilområden,Other operations, LTH,Faculty of Engineering, LTH,Other operations, LTH,Faculty of Engineering, LTH,Ergonomics and Aerosol Technology,Department of Design Sciences,Departments at LTH,Faculty of Engineering, LTH,LTH Profile Area: Aerosols,LTH Profile areas,Faculty of Engineering, LTH
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- Nygren, David (författare)
- Lund University,Lunds universitet,Translationell infektionsmedicin,Forskargrupper vid Lunds universitet,Translational infection medicine,Lund University Research Groups
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- Thuresson, Sara (författare)
- Lund University,Lunds universitet,Metalund,Annan verksamhet, LTH,Lunds Tekniska Högskola,NanoLund: Centre for Nanoscience,Annan verksamhet, LTH,Ergonomi och aerosolteknologi,Institutionen för designvetenskaper,Institutioner vid LTH,LTH profilområde: Aerosoler,LTH profilområden,Other operations, LTH,Faculty of Engineering, LTH,Other operations, LTH,Faculty of Engineering, LTH,Ergonomics and Aerosol Technology,Department of Design Sciences,Departments at LTH,Faculty of Engineering, LTH,LTH Profile Area: Aerosols,LTH Profile areas,Faculty of Engineering, LTH
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- 2022-11-04
- 2023
- Engelska.
- Ingår i: Infectious Diseases. - : Informa UK Limited. - 2374-4235 .- 2374-4243. ; 55:2, s. 158-163
- Tidskriftsartikel (refereegranskat)
Abstract
Ämnesord
Stäng
- Background: SARS-CoV-2 in exhaled aerosols is considered an important contributor to the spread of COVID-19. However, characterizing the size distribution of virus-containing aerosol particles has been challenging as high concentrations of SARS-CoV-2 in exhaled air is mainly present close to symptom onset. We present a case study of a person with COVID-19 who was able to participate in extensive measurements of exhaled aerosols already on the day of symptom onset and then for the following three days. Methods: Aerosol collection was performed using an eight-stage impactor while the subject was breathing, talking and singing, for 30 min each, once every day. In addition, nasopharyngeal samples, saliva samples, room air samples and information on symptom manifestations were collected every day. Samples were analyzed by RT-qPCR for detection of SARS-CoV-2 RNA. Results: SARS-CoV-2 RNA was detected in seven of the eight particle size fractions, from 0.34 to >8.1 µm, with the highest concentrations found in 0.94–2.8 µm particles. The concentration of SARS-CoV-2 RNA was highest on the day of symptom onset, and declined for each day thereafter. Conclusion: Our data showed that 90% of the exhaled SARS-CoV-2 RNA was found in aerosol particles <4.5 µm, indicating the importance of small particles for the transmission of COVID-19 close to symptom onset. These results are important for our understanding of airborne transmission, for developing accurate models and for selecting appropriate mitigation strategies.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
Nyckelord
- cascade impactor
- COVID-19
- exhaled aerosol
- SARS-CoV-2
- size distribution
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- Alsved, Malin
- Nygren, David
- Thuresson, Sara
- Fraenkel, Carl J ...
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- Löndahl, Jakob
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