Associations of defect mismatch repair genes with prognosis and heredity in sporadic colorectal cancer

Ghanipour, LanaUppsala universitet,Uppsala University,Kolorektalkirurgi (author)

Background Microsatellite instability arises due to defect mismatch repair (MMR) and occurs in 10–20% of sporadic colorectal cancer. The purpose was to investigate correlations between defect MMR, prognosis and heredity for colorectal cancer in first-degree relatives. Material and methods Tumour tissues from 318 patients consecutively operated for colorectal cancer were analysed for immunohistochemical expression of MLH1, MSH2 and MSH6 on tissue microarrays. Information on KRAS and BRAF mutation status was available for selected cases. Results Forty-seven (15%) tumours displayed MSI. No correlation was seen between patients exhibiting MSI in the tumour and heredity (p = 0.789). Patients with proximal colon cancer and MSI had an improved cancer-specific survival (p = 0.006) and prolonged time to recurrence (p = 0.037). In a multivariate analysis including MSI status, gender, CEA, vascular and neural invasion, patients with MSS and proximal colon cancer had an impaired cancer-specific survival compared with patients with MSI (HR, 4.32; CI, 1.46–12.78). The same prognostic information was also seen in distal colon cancer; no recurrences seen in the eight patients with stages II and III distal colon cancer and MSI, but the difference was not statistically significant. Conclusion No correlation between MSI and heredity for colorectal cancer in first-degree relatives was seen. Patients with MSI tumours had improved survival.

Jirström, K.Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Personlig patologi och cancerbehandling,Forskargrupper vid Lunds universitet,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Personalized Pathology & Cancer Therapy,Lund University Research Groups,Lund Univ, Div Oncol Pathol, Dept Clin Sci, Lund, Sweden.(Swepub:lu)pat-kji (author)
Sundström, MagnusUppsala universitet,Uppsala University,Institutionen för immunologi, genetik och patologi(Swepub:uu)magnsund (author)
Glimelius, BengtUppsala universitet,Uppsala University,Institutionen för radiologi, onkologi och strålningsvetenskap,Institutionen för immunologi, genetik och patologi(Swepub:uu)bengglim (author)
Birgisson, H.Uppsala universitet,Uppsala University,Kolorektalkirurgi(Swepub:uu)hebir255 (author)
Påhlman, LarsUppsala universitet,Kolorektalkirurgi(Swepub:uu)larspahl (author)
Uppsala UniversityKolorektalkirurgi (creator_code:org_t)

In:European Journal of Surgical Oncology: Elsevier BV43:2, s. 311-3210748-79831532-2157

By the author/editor: Ghanipour, Lana; Jirström, K.; Sundström, Magnu ...; Glimelius, Bengt; Birgisson, H.; Påhlman, Lars

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cancer and Oncol ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Medical Genetics

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Surgery

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