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Renal arteriovenous...
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Nilsson, Lisbet
(författare)
Renal arteriovenous shunting in rejecting allograft, hydronephrosis, or haemorrhagic hypotension in the rat
- Artikel/kapitelEngelska1994
Förlag, utgivningsår, omfång ...
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1994
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Oxford University Press (OUP),1994
Nummerbeteckningar
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LIBRIS-ID:oai:lup.lub.lu.se:01e75cd7-35cf-4bbc-98d8-ac44cffc51c8
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https://lup.lub.lu.se/record/01e75cd7-35cf-4bbc-98d8-ac44cffc51c8URI
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https://doi.org/10.1093/ndt/9.11.1634DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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Ämneskategori:ref swepub-contenttype
Anmärkningar
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We studied the occurrence of arteriovenous (A-V) shunting in three experimental rat models, namely in rejecting allograft kidney, in uni- or bilateral ureteral obstruction, and in haemorrhagic hypotension. Isografted or sham-operated rats served as controls. Radiolabelled microspheres were injected into the renal artery and the increase in the amount of radioactivity in the lungs was considered to reflect A-V shunting in the kidney. In animals exposed to haemorrhage, with a blood pressure not less than 70% of the initial blood pressure, practically no shunting was seen. When animals were bled to a hypotension beyond the autoregulation, A-V shunting occurred inversely correlated to the degree of hypotension. In ureteral obstruction, a less marked but significant increase in shunting of microspheres to the lungs was found after 24 h of unilateral obstruction, irrespective of whether the spheres were injected into the obstructed or the contralateral kidney. Significant A-V shunting during the allograft rejection process was also demonstrated. Histologically, microspheres were found in afferent arterioles less frequently in kidneys with A-V shunting than in controls. These results indicate that A-V shunting is involved in haemorrhagic hypotension, renal graft rejection, and hydronephrosis. In the latter situation A-V shunting is probably regulated by a humoral factor. © 1994 European Dialysis and Transplant Association-European Renal Association.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Ekberg, HenrikLund University,Lunds universitet,Enheten för forskning kring njurfunktion och njursjukdom,Kirurgi,Forskargrupper vid Lunds universitet,Renal Research Unit,Surgery,Lund University Research Groups(Swepub:lu)kir-hek
(författare)
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Fält, KSkåne University Hospital
(författare)
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Löfberg, HelgeLund University,Lunds universitet,Patologi, Malmö,Forskargrupper vid Lunds universitet,Pathology, Malmö,Lund University Research Groups,Skåne University Hospital(Swepub:lu)pat-hlo
(författare)
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Sterner, GunnarLund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups,Skåne University Hospital(Swepub:lu)medf-gst
(författare)
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Enheten för forskning kring njurfunktion och njursjukdomKirurgi
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association: Oxford University Press (OUP)9:11, s. 1634-16391460-2385
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