SwePub
Sök i LIBRIS databas

  Extended search

id:"swepub:oai:lup.lub.lu.se:020ee7b0-1ea7-4558-a0b5-ae7817c14f5c"
 

Search: id:"swepub:oai:lup.lub.lu.se:020ee7b0-1ea7-4558-a0b5-ae7817c14f5c" > Association of free...

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist
  • Steuber, T (author)

Association of free-prostate specific antigen subfractions and human glandular kallikrein 2 with volume of benign and malignant prostatic tissue

  • Article/chapterEnglish2005

Publisher, publication year, extent ...

  • 2005
  • Wiley,2005

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:020ee7b0-1ea7-4558-a0b5-ae7817c14f5c
  • https://lup.lub.lu.se/record/248319URI
  • https://doi.org/10.1002/pros.20156DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • BACKGROUND. We investigated the association of different subfractions of prostate specific antigen (PSA) and human glandular kallikrein 2 (hK2), such as total PSA (tPSA), complexed PSA (cPSA), free PSA (fPSA), "single-chain Intact fPSA" (fPSA-I), "multi-chain nicked fPSA" (fPSA-N), and total hK2 with volumes of total prostate gland, transition zone (tz), and prostate cancer (PCa) tissue in patients with benign and malignant prostatic disease. METHODS. Serum samples were collected from men with negative biopsy (n = 164) and PCa (n = 252). Total and fPSA were measured using a commercially immunoassay. We measured hK2 and fPSA-I by previously reported in-house research assays specific for hK2 and single-chain, non-cleaved fPSA, respectively. Levels of fPSA-N (=fPSA-fPSA-I) and cPSA (=tPSA-fPSA) were calculated. Total prostate and tz volume were measured using transrectal ultrasound (TRUS); PCa volume was calculated using a computer assisted volumetric program. Association with tz and cancer volumes (CaVols) was performed by linear regression analysis. RESULTS. All PSA subfractions and hK2 were associated with tz volume in multivariable linear regression analysis. Only hK2, fPSA, and fPSA-N were significantly associated with CaVol in multivariable analysis, fPSA-I seemed to be cancer related. CONCLUSIONS. The multi-chain fPSA-N subfractions of fPSA may be a valuable predictor of both benign prostate hyperplasia (BPH) and CaVol that is likely to be more useful in predicting tz volumes than CaVols. fPSA-I may provide information on cancer without being influenced by the presence of BPH.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Niemela, P (author)
  • Haese, A (author)
  • Pettersson, K (author)
  • Erbersdobler, A (author)
  • Chun, K H F (author)
  • Graefen, M (author)
  • Kattan, M W (author)
  • Huland, H (author)
  • Lilja, HansLund University,Lunds universitet,Klinisk kemi, Malmö,Forskargrupper vid Lunds universitet,Clinical Chemistry, Malmö,Lund University Research Groups(Swepub:lu)klke-hli (author)
  • Klinisk kemi, MalmöForskargrupper vid Lunds universitet (creator_code:org_t)

Related titles

  • In:The Prostate: Wiley63:1, s. 13-180270-41371097-0045

Internet link

Find in a library

To the university's database

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

Find more in SwePub

By the author/editor
Steuber, T
Niemela, P
Haese, A
Pettersson, K
Erbersdobler, A
Chun, K H F
show more...
Graefen, M
Kattan, M W
Huland, H
Lilja, Hans
show less...
About the subject
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Clinical Medicin ...
and Obstetrics Gynae ...
Articles in the publication
The Prostate
By the university
Lund University

Search outside SwePub

Wikipedia about the author:
T_Steuber
Steuber, T
en

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view