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  • Ising, ErikLund University,Lunds universitet,Pediatrisk endokrinologi,Forskargrupper vid Lunds universitet,Paediatric Endocrinology,Lund University Research Groups,Skåne University Hospital,Lund Univ, Sweden; Skane Univ Hosp, Sweden (author)

Quantification of heat shock proteins in the posterior interosseous nerve among subjects with type 1 and type 2 diabetes compared to healthy controls

  • Article/chapterEnglish2023

Publisher, publication year, extent ...

  • FRONTIERS MEDIA SA,2023

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:0247f87d-ad50-46aa-b296-c1c886326df3
  • https://lup.lub.lu.se/record/0247f87d-ad50-46aa-b296-c1c886326df3URI
  • https://doi.org/10.3389/fnins.2023.1227557DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-197532URI

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  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Introduction: Diabetic peripheral neuropathy (DPN) is a common complication of both type 1 (T1D) and type 2 diabetes (T2D). No cure for DPN is available, but several potential targets have been proposed for treatment. Heat shock proteins (HSPs) are known to respond to both hyper- and hypoglycemia. DPN can be diagnosed using electrophysiology and studied using peripheral nerve biopsies.Aim: This study aimed to analyze the presence and patterns of HSPs in peripheral nerve biopsies from subjects with T1D, T2D, and healthy controls.Methods: Posterior interosseous nerves (PIN) from a total of 56 subjects with T1D (n = 9), with T2D (n = 24), and without diabetes (i.e., healthy controls, n = 23) were harvested under local anesthesia and prepared for quantitative mass spectrometry analysis. Protein intensities were associated with electrophysiology data of the ulnar nerve and morphometry of the same PIN, and differences in protein intensities between groups were analyzed.Results: In total, 32 different HSPs were identified and quantified in the nerve specimens. No statistically significant differences were observed regarding protein intensities between groups. Furthermore, protein intensities did not correlate with amplitude or conduction velocity in the ulnar nerve or with the myelinated nerve fiber density of PIN.Conclusion: Quantitative proteomics can be used to study HSPs in nerve biopsies, but no clear differences in protein quantities were observed between groups in this cohort.

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  • Åhrman, EmmaLund University,Lunds universitet,Infection Medicine Proteomics,Forskargrupper vid Lunds universitet,Lund University Research Groups,Lund Univ, Sweden(Swepub:lu)biok-eah (author)
  • Thomsen, Niels O. B.Lund University,Lunds universitet,Handkirurgi, Malmö,Forskargrupper vid Lunds universitet,Hand Surgery, Malmö,Lund University Research Groups,Skåne University Hospital,Lund Univ, Sweden; Skane Univ Hosp, Sweden(Swepub:lu)hand-nth (author)
  • Åkesson, AnnaClinical Studies Sweden-Forum South,Skane Univ Hosp, Sweden (author)
  • Malmström, JohanLund University,Lunds universitet,Infektionsmedicin,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Infection Medicine Proteomics,Forskargrupper vid Lunds universitet,SEBRA Sepsis and Bacterial Resistance Alliance,epIgG,Masspektrometri,Sektion V,Institutionen för kliniska vetenskaper, Lund,BioMS,LTH profilområde: Teknik för hälsa,LTH profilområden,Lunds Tekniska Högskola,Infection Medicine (BMC),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups,Mass Spectrometry,Section V,Department of Clinical Sciences, Lund,LTH Profile Area: Engineering Health,LTH Profile areas,Faculty of Engineering, LTH,Lund Univ, Sweden(Swepub:lu)medk-jma (author)
  • Dahlin, Lars B.Linköpings universitet,Linköping University,Lund University,Lunds universitet,Institutionen för translationell medicin,Medicinska fakulteten,Handkirurgi, Malmö,Forskargrupper vid Lunds universitet,WCMM- Wallenberg center för molekylär medicinsk forskning,Department of Translational Medicine,Faculty of Medicine,Hand Surgery, Malmö,Lund University Research Groups,WCMM-Wallenberg Centre for Molecular Medicine,Skåne University Hospital,Avdelningen för kirurgi, ortopedi och onkologi,Lund Univ, Sweden; Skane Univ Hosp, Sweden(Swepub:liu)larda57 (author)
  • Pediatrisk endokrinologiForskargrupper vid Lunds universitet (creator_code:org_t)

Related titles

  • In:Frontiers in Neuroscience: FRONTIERS MEDIA SA171662-45481662-453X

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