Bioengineering Approaches for the Distal Lung

• Chronic and acute lung diseases are the third and fourth leading causes of global mortality. Distal lung tissue is severely damaged in many lung diseases, causing respiratory insufficiency from loss of surface area available for gas exchange. Current therapies aim at relieving symptoms and are unable to reverse disease. Lung transplantation remains the only potential curative option at end-stage disease but is severely limited by a lack of suitable donor lungs and low long-term survival. Bioengineering lung tissue or bioengineering cells with biomaterials for transplantation is an exciting new approach to (re)generate tissue to close this large unmet clinical need.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)

Nyckelord

3D bioprinting

Alveolar

Bioengineering

Bioreactor

Chronic lung disease

Chronic obstructive pulmonary disease

Decellularization

Extracellular matrix

Pulmonary fibrosis

Pulmonary hypertension

Scaffold

Small airways

Synthetic scaffold

Publikations- och innehållstyp

kap (ämneskategori)

ref (ämneskategori)