Interleukin-1 receptor accessory protein (IL-1RAP) : A magic bullet candidate for immunotherapy of human malignancies

IL-1, plays a role in some pathological inflammatory conditions. This pro-inflammatory cytokine also has a crucial role in tumorigenesis and immune responses in the tumor microenvironment (TME). IL-1 receptor accessory protein (IL-1RAP), combined with IL-1 receptor-1, provides a functional complex for binding and signaling. In addition to the direct role of IL-1, some studies demonstrated that IL1-RAP has essential roles in the progression, angiogenesis, and metastasis of solid tumors such as gastrointestinal tumors, lung carcinoma, glioma, breast and cervical cancers. This molecule also interacts with FLT-3 and c-Kit tyrosine kinases and is involved in the pathogenesis of hematological malignancies such as acute myeloid lymphoma. Additionally, IL-1RAP interacts with solute carrier family 3 member 2 (SLC3A2) and thereby increasing the resistance to anoikis and metastasis in Ewing sarcoma. This review summarizes the role of IL-1RAP in different types of cancers and discusses its targeting as a novel therapeutic approach for malignancies.

Shahba, FaezehIran University of Medical Sciences (författare)
Khorramdelazad, HosseinRafsanjan University of Medical Sciences (författare)
Aghamohammadi, NazaninIran University of Medical Sciences (författare)
Karimi, MiladIran University of Medical Sciences (författare)
Bagherzadeh, KowsarIran University of Medical Sciences (författare)
Khoshmirsafa, MajidIran University of Medical Sciences (författare)
Massoumi, RaminLund University,Lunds universitet,Avdelningen för translationell cancerforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Molekylär tumörpatologi,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Division of Translational Cancer Research,Department of Laboratory Medicine,Faculty of Medicine,Molecular Tumor Pathology,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments(Swepub:lu)expp-rma (författare)
Falak, RezaIran University of Medical Sciences (författare)
Iran University of Medical SciencesRafsanjan University of Medical Sciences (creator_code:org_t)

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