Sökning: id:"swepub:oai:lup.lub.lu.se:02b89c8e-5b01-4d18-b026-6accc9af219f" >
Interleukin-1 recep...
-
Zarezadeh Mehrabadi, AliIran University of Medical Sciences
(författare)
Interleukin-1 receptor accessory protein (IL-1RAP) : A magic bullet candidate for immunotherapy of human malignancies
- Artikel/kapitelEngelska2024
Förlag, utgivningsår, omfång ...
Nummerbeteckningar
-
LIBRIS-ID:oai:lup.lub.lu.se:02b89c8e-5b01-4d18-b026-6accc9af219f
-
https://lup.lub.lu.se/record/02b89c8e-5b01-4d18-b026-6accc9af219fURI
-
https://doi.org/10.1016/j.critrevonc.2023.104200DOI
Kompletterande språkuppgifter
-
Språk:engelska
-
Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
-
Ämneskategori:for swepub-publicationtype
-
Ämneskategori:ref swepub-contenttype
Anmärkningar
-
IL-1, plays a role in some pathological inflammatory conditions. This pro-inflammatory cytokine also has a crucial role in tumorigenesis and immune responses in the tumor microenvironment (TME). IL-1 receptor accessory protein (IL-1RAP), combined with IL-1 receptor-1, provides a functional complex for binding and signaling. In addition to the direct role of IL-1, some studies demonstrated that IL1-RAP has essential roles in the progression, angiogenesis, and metastasis of solid tumors such as gastrointestinal tumors, lung carcinoma, glioma, breast and cervical cancers. This molecule also interacts with FLT-3 and c-Kit tyrosine kinases and is involved in the pathogenesis of hematological malignancies such as acute myeloid lymphoma. Additionally, IL-1RAP interacts with solute carrier family 3 member 2 (SLC3A2) and thereby increasing the resistance to anoikis and metastasis in Ewing sarcoma. This review summarizes the role of IL-1RAP in different types of cancers and discusses its targeting as a novel therapeutic approach for malignancies.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
-
Shahba, FaezehIran University of Medical Sciences
(författare)
-
Khorramdelazad, HosseinRafsanjan University of Medical Sciences
(författare)
-
Aghamohammadi, NazaninIran University of Medical Sciences
(författare)
-
Karimi, MiladIran University of Medical Sciences
(författare)
-
Bagherzadeh, KowsarIran University of Medical Sciences
(författare)
-
Khoshmirsafa, MajidIran University of Medical Sciences
(författare)
-
Massoumi, RaminLund University,Lunds universitet,Avdelningen för translationell cancerforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Molekylär tumörpatologi,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Division of Translational Cancer Research,Department of Laboratory Medicine,Faculty of Medicine,Molecular Tumor Pathology,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments(Swepub:lu)expp-rma
(författare)
-
Falak, RezaIran University of Medical Sciences
(författare)
-
Iran University of Medical SciencesRafsanjan University of Medical Sciences
(creator_code:org_t)
Sammanhörande titlar
-
Ingår i:Critical Reviews in Oncology/Hematology1931040-8428
Internetlänk
Hitta via bibliotek
Till lärosätets databas