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Dietary intakes of ...
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Fiolet, ThibaultEuropean Food Safety Authority,Versailles Saint-Quentin-en-Yvelines University
(författare)
Dietary intakes of dioxins and polychlorobiphenyls (PCBs) and mortality : EPIC cohort study in 9 European countries
- Artikel/kapitelEngelska2024
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Nummerbeteckningar
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LIBRIS-ID:oai:lup.lub.lu.se:02dc7791-115d-4271-839e-f54eb44b950c
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https://lup.lub.lu.se/record/02dc7791-115d-4271-839e-f54eb44b950cURI
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https://doi.org/10.1016/j.ijheh.2023.114287DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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Ämneskategori:ref swepub-contenttype
Anmärkningar
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Dioxins and polychlorinated biphenyls (PCBs) are toxic, endocrine disruptors and persistent chemicals for which the main exposure source is diet due to their bioaccumulation and biomagnification in food chains. Cohort studies in the general populations have reported inconsistent associations between these chemicals in serum/plasma and mortality. Our objective was to study the association between dietary intake of 17 dioxins and 35 PCBs and all-cause, cancer-specific and cardiovascular-specific mortalities were assessed in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Dietary intake of dioxins and PCBs was assessed combining EPIC food consumption data with European food contamination data provided by the European Food Safety Authority. We applied multivariable Cox regressions. The analysis included 451,390 adults (mean ± SD age:51.1 ± 9.7 years) with 46,627 deaths and a median follow-up of 17.4 years (IQR = 15.2–19.1). A U-shaped non-linear association with all-cause mortality for dietary intake of dioxins (Pnon-linearity<0.0001), DL-PCB (Pnon-linearity = 0.0001), and NDL-PCBs (Pnon-linearity<0.01) was observed. For example, the hazard ratios (95%Confidance interval) for all-cause mortality obtained with the spline model was equal to 1.03 (1.02–1.05) for low levels of intake to dioxins (7 pg TEQ/day), 0.93 (0.90–0.96) for moderate levels of intake (25 pg TEQ/day), while for high levels of intake (55 pg TEQ/day) it was 1.03 (0.97–1.09). Intake of dioxins, DL-PCBs and NDL-PCBs was not associated with cardiovascular mortality. There was no association between intakes of dioxins and cancer mortality, but a U-shaped association was observed for intake of DL-PCBs and intakes of NDL-PCBs and cancer mortality. The PCBs and dioxins are known to have endocrine disrupting properties which can lead to non-monotonic dose responses. These results need to be interpreted with caution and further studies are needed to better clarify the association between dietary intake of dioxins and PCB and mortality in the general population.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Nicolas, GenevièveInternational Agency for Research on Cancer, World Health Organization
(författare)
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Casagrande, CorinneInternational Agency for Research on Cancer, World Health Organization
(författare)
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Horvath, ZsuzsannaEuropean Food Safety Authority
(författare)
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Frenoy, PaulineVersailles Saint-Quentin-en-Yvelines University
(författare)
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Weiderpass, ElisabeteInternational Agency for Research on Cancer, World Health Organization
(författare)
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Gunter, Marc J.International Agency for Research on Cancer, World Health Organization
(författare)
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Manjer, JonasLund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups,Skåne University Hospital(Swepub:lu)smi-jma
(författare)
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Sonestedt, EmilyLund University,Lunds universitet,Nutritionsepidemiologi,Forskargrupper vid Lunds universitet,Nutrition Epidemiology,Lund University Research Groups(Swepub:lu)medf-eso
(författare)
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Palli, DomenicoInstitute for Cancer Research, Prevention and Clinical Network (ISPRO)
(författare)
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Simeon, Vittorio
(författare)
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Tumino, RosarioHyblean Association for Epidemiological Research
(författare)
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Bueno-de-Mesquita, BasNational Institute for Public Health and the Environment (RIVM)
(författare)
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Huerta, José MaríaMurcia Regional Health Council,CIBER Epidemiology and Public Health (CIBERESP)
(författare)
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Rodriguez-Barranco, MiguelCIBER Epidemiology and Public Health (CIBERESP),Andalusian School Of Public Health (EASP)
(författare)
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Abilleira, EunateMinistry of Health of the Basque Government,Biodonostia Health Research Institute
(författare)
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Sacerdote, CarlottaCitta' della Salute e della Scienza Hospital-University of Turin
(författare)
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Schulze, Matthias B.University of Potsdam,German Institute of Human Nutrition
(författare)
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Heath, Alicia K.Imperial College London
(författare)
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Rylander, CharlottaUiT The Arctic University of Norway, Tromsø
(författare)
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Skeie, GuriUiT The Arctic University of Norway, Tromsø
(författare)
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Nøst, Therese HaugdahlUiT The Arctic University of Norway, Tromsø
(författare)
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Tjønneland, AnneDanish Cancer Society,University of Copenhagen
(författare)
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Olsen, AnjaDanish Cancer Society,Aarhus University
(författare)
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Pala, ValeriaIstituto Nazionale dei Tumori
(författare)
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Kvaskoff, MarinaVersailles Saint-Quentin-en-Yvelines University
(författare)
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Huybrechts, IngeInternational Agency for Research on Cancer, World Health Organization
(författare)
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Mancini, Francesca RomanaVersailles Saint-Quentin-en-Yvelines University
(författare)
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European Food Safety AuthorityVersailles Saint-Quentin-en-Yvelines University
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:International Journal of Hygiene and Environmental Health2551438-4639
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Fiolet, Thibault
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Nicolas, Geneviè ...
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Casagrande, Cori ...
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Horvath, Zsuzsan ...
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Frenoy, Pauline
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Weiderpass, Elis ...
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visa fler...
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Gunter, Marc J.
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Manjer, Jonas
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Sonestedt, Emily
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Palli, Domenico
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Simeon, Vittorio
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Tumino, Rosario
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Bueno-de-Mesquit ...
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Huerta, José Mar ...
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Rodriguez-Barran ...
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Abilleira, Eunat ...
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Sacerdote, Carlo ...
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Schulze, Matthia ...
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Heath, Alicia K.
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Rylander, Charlo ...
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Skeie, Guri
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Nøst, Therese Ha ...
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Tjønneland, Anne
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Olsen, Anja
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Pala, Valeria
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Kvaskoff, Marina
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Huybrechts, Inge
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Mancini, Frances ...
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