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EuroInf 2 : Subthal...
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Dafsari, Haidar S.King's College Hospital,University Hospital of Cologne
(author)
EuroInf 2 : Subthalamic stimulation, apomorphine, and levodopa infusion in Parkinson's disease
- Article/chapterEnglish2019
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LIBRIS-ID:oai:lup.lub.lu.se:03b24aa0-59ad-4f4e-9ca6-f384f8cdb735
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https://lup.lub.lu.se/record/03b24aa0-59ad-4f4e-9ca6-f384f8cdb735URI
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https://doi.org/10.1002/mds.27626DOI
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
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Objective: Real-life observational report of clinical efficacy of bilateral subthalamic stimulation (STN-DBS), apomorphine (APO), and intrajejunal levodopa infusion (IJLI) on quality of life, motor, and nonmotor symptoms (NMS) in Parkinson's disease (PD). Methods: In this prospective, multicenter, international, real-life cohort observation study of 173 PD patients undergoing STN-DBS (n = 101), IJLI (n = 33), or APO (n = 39) were followed-up using PDQuestionnaire-8, NMSScale (NMSS), Unified PD Rating Scale (UPDRS)-III, UPDRS-IV, and levodopa equivalent daily dose (LEDD) before and 6 months after intervention. Outcome changes were analyzed with Wilcoxon signed-rank or paired t test when parametric tests were applicable. Multiple comparisons were corrected (multiple treatments/scales). Effect strengths were quantified with relative changes, effect size, and number needed to treat. Analyses were computed before and after propensity score matching, balancing demographic and clinical characteristics. Results: In all groups, PDQuestionnaire-8, UPDRS-IV, and NMSS total scores improved significantly at follow-up. Levodopa equivalent daily dose was significantly reduced after STN-DBS. Explorative NMSS domain analyses resulted in distinct profiles: STN-DBS improved urinary/sexual functions, mood/cognition, sleep/fatigue, and the miscellaneous domain. IJLI improved the 3 latter domains and gastrointestinal symptoms. APO improved mood/cognition, perceptual problems/hallucinations, attention/memory, and the miscellaneous domain. Overall, STN-DBS and IJLI seemed favorable for NMSS total score, and APO favorable for neuropsychological/neuropsychiatric NMS and PDQuestionnaire-8 outcome. Conclusions: This is the first comparison of quality of life, nonmotor. and motor outcomes in PD patients undergoing STN-DBS, IJLI, and APO in a real-life cohort. Distinct effect profiles were identified for each treatment option. Our results highlight the importance of holistic nonmotor and motor symptoms assessments to personalize treatment choices.
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Martinez-Martin, PabloCarlos III Health Institute
(author)
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Rizos, AlexandraKing's College Hospital
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Trost, MajaUniversity Medical Centre Ljubljana
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dos Santos Ghilardi, Maria GabrielaUniversity of São Paulo
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Reddy, PrashanthKing's College Hospital
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Sauerbier, AnnaKing's College London,King's College Hospital
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Petry-Schmelzer, Jan NiklasUniversity Hospital of Cologne
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Kramberger, MilicaUniversity Medical Centre Ljubljana
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Borgemeester, Robbert W.K.University Medical Center Groningen,University of Groningen
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Barbe, Michael T.University Hospital of Cologne
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Ashkan, KeyoumarsKing's College Hospital
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Silverdale, MontyUniversity of Manchester
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Evans, JulianUniversity of Manchester
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Odin, PerLund University,Lunds universitet,Restorative Parkinson Unit,Forskargrupper vid Lunds universitet,Lund University Research Groups,Central Hospital Bremerhaven(Swepub:lu)med-poi
(author)
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Fonoff, Erich TalamoniSyrian-Lebanese Hospital,University of São Paulo
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Fink, Gereon R.Jülich Research Centre,University Hospital of Cologne
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Henriksen, ToveBispebjerg Hospital
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Ebersbach, GeorgKliniken Beelitz GmbH
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Pirtošek, ZvezdanUniversity Medical Centre Ljubljana
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Visser-Vandewalle, VeerleUniversity Hospital of Cologne
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Antonini, AngeloUniversity of Padova,San Camillo Hospital
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Timmermann, LarsUniversity Hospital of Cologne,University Hospital Giessen and Marburg
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Ray Chaudhuri, K.King's College London,King's College Hospital
(author)
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King's College HospitalUniversity Hospital of Cologne
(creator_code:org_t)
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EUROPAR
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In:Movement Disorders: Wiley0885-31851531-8257
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Martinez-Martin, ...
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Rizos, Alexandra
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Trost, Maja
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dos Santos Ghila ...
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Reddy, Prashanth
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Sauerbier, Anna
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Petry-Schmelzer, ...
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Kramberger, Mili ...
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Borgemeester, Ro ...
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Barbe, Michael T ...
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Ashkan, Keyoumar ...
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Silverdale, Mont ...
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Evans, Julian
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Odin, Per
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Fonoff, Erich Ta ...
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Fink, Gereon R.
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Henriksen, Tove
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Ebersbach, Georg
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Pirtošek, Zvezda ...
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