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  • Dafsari, Haidar S.King's College Hospital,University Hospital of Cologne (author)

EuroInf 2 : Subthalamic stimulation, apomorphine, and levodopa infusion in Parkinson's disease

  • Article/chapterEnglish2019

Publisher, publication year, extent ...

  • 2019-02-04
  • Wiley,2019

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:03b24aa0-59ad-4f4e-9ca6-f384f8cdb735
  • https://lup.lub.lu.se/record/03b24aa0-59ad-4f4e-9ca6-f384f8cdb735URI
  • https://doi.org/10.1002/mds.27626DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Objective: Real-life observational report of clinical efficacy of bilateral subthalamic stimulation (STN-DBS), apomorphine (APO), and intrajejunal levodopa infusion (IJLI) on quality of life, motor, and nonmotor symptoms (NMS) in Parkinson's disease (PD). Methods: In this prospective, multicenter, international, real-life cohort observation study of 173 PD patients undergoing STN-DBS (n = 101), IJLI (n = 33), or APO (n = 39) were followed-up using PDQuestionnaire-8, NMSScale (NMSS), Unified PD Rating Scale (UPDRS)-III, UPDRS-IV, and levodopa equivalent daily dose (LEDD) before and 6 months after intervention. Outcome changes were analyzed with Wilcoxon signed-rank or paired t test when parametric tests were applicable. Multiple comparisons were corrected (multiple treatments/scales). Effect strengths were quantified with relative changes, effect size, and number needed to treat. Analyses were computed before and after propensity score matching, balancing demographic and clinical characteristics. Results: In all groups, PDQuestionnaire-8, UPDRS-IV, and NMSS total scores improved significantly at follow-up. Levodopa equivalent daily dose was significantly reduced after STN-DBS. Explorative NMSS domain analyses resulted in distinct profiles: STN-DBS improved urinary/sexual functions, mood/cognition, sleep/fatigue, and the miscellaneous domain. IJLI improved the 3 latter domains and gastrointestinal symptoms. APO improved mood/cognition, perceptual problems/hallucinations, attention/memory, and the miscellaneous domain. Overall, STN-DBS and IJLI seemed favorable for NMSS total score, and APO favorable for neuropsychological/neuropsychiatric NMS and PDQuestionnaire-8 outcome. Conclusions: This is the first comparison of quality of life, nonmotor. and motor outcomes in PD patients undergoing STN-DBS, IJLI, and APO in a real-life cohort. Distinct effect profiles were identified for each treatment option. Our results highlight the importance of holistic nonmotor and motor symptoms assessments to personalize treatment choices.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Martinez-Martin, PabloCarlos III Health Institute (author)
  • Rizos, AlexandraKing's College Hospital (author)
  • Trost, MajaUniversity Medical Centre Ljubljana (author)
  • dos Santos Ghilardi, Maria GabrielaUniversity of São Paulo (author)
  • Reddy, PrashanthKing's College Hospital (author)
  • Sauerbier, AnnaKing's College Hospital,King's College London (author)
  • Petry-Schmelzer, Jan NiklasUniversity Hospital of Cologne (author)
  • Kramberger, MilicaUniversity Medical Centre Ljubljana (author)
  • Borgemeester, Robbert W.K.University Medical Center Groningen,University of Groningen (author)
  • Barbe, Michael T.University Hospital of Cologne (author)
  • Ashkan, KeyoumarsKing's College Hospital (author)
  • Silverdale, MontyUniversity of Manchester (author)
  • Evans, JulianUniversity of Manchester (author)
  • Odin, PerLund University,Lunds universitet,Restorative Parkinson Unit,Forskargrupper vid Lunds universitet,Lund University Research Groups,Central Hospital Bremerhaven(Swepub:lu)med-poi (author)
  • Fonoff, Erich TalamoniUniversity of São Paulo,Syrian-Lebanese Hospital (author)
  • Fink, Gereon R.Jülich Research Centre,University Hospital of Cologne (author)
  • Henriksen, ToveBispebjerg Hospital (author)
  • Ebersbach, GeorgKliniken Beelitz GmbH (author)
  • Pirtošek, ZvezdanUniversity Medical Centre Ljubljana (author)
  • Visser-Vandewalle, VeerleUniversity Hospital of Cologne (author)
  • Antonini, AngeloSan Camillo Hospital,University of Padova (author)
  • Timmermann, LarsUniversity Hospital of Cologne,University Hospital Giessen and Marburg (author)
  • Ray Chaudhuri, K.King's College London,King's College Hospital (author)
  • King's College HospitalUniversity Hospital of Cologne (creator_code:org_t)
  • EUROPAR

Related titles

  • In:Movement Disorders: Wiley0885-31851531-8257

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