Performance of the European Kidney Function Consortium (EKFC) creatinine-based equation in United States cohorts

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Delanaye, PierreCHU Nîmes,University of Liège Hospital (author)

Performance of the European Kidney Function Consortium (EKFC) creatinine-based equation in United States cohorts

Article/chapterEnglish2024

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2024
9 s.

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LIBRIS-ID:oai:lup.lub.lu.se:03dced2e-f032-463b-aef3-84e3069c30d1
https://lup.lub.lu.se/record/03dced2e-f032-463b-aef3-84e3069c30d1URI
https://doi.org/10.1016/j.kint.2023.11.024DOI

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Language:English
Summary in:English

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Estimating glomerular filtration rate (GFR) is important in daily practice to assess kidney function and adapting the best clinical care of patients with and without chronic kidney disease. The new creatinine-based European Kidney Function Consortium (EKFC) equation is used to estimate GFR. This equation was developed and validated mainly in European individuals and based on a rescaled creatinine, with the rescaling factor (Q-value) defined as the median normal value of serum creatinine in a given population. The validation was limited in Non-Black Americans and absent in Black Americans. Here, our cross-sectional analysis included 12,854 participants from nine studies encompassing large numbers of both non-Black and Black Americans with measured GFR by clearance of an exogenous marker (reference method), serum creatinine, age, sex, and self-reported race available. Two strategies were considered with population-specific Q-values in Black and non-Black men and women (EKFCPS) or a race-free Q-value (EKFCRF). In the whole population, only the EKFCPS equation showed no statistical median bias (0.14, 95% confidence interval [-0.07; 0.35] mL/min/1.73m2), and the bias for the EKFCRF (0.74, [0.51; 0.94] mL/min/1.73m2) was closer to zero than that for the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI2021) equation (1.22, [0.99; 1.47]) mL/min/1.73m2]. The percentage of estimated GFR within 30% of measured GFR was similar for CKD-EPI2021 (79.2% [78.5%; 79.9%]) and EKFCRF (80.1% [79.4%; 80.7%]), but improved for the EKFCPS equation (81.1% [80.5%; 81.8%]). Thus, our EKFC equations can be used to estimate GFR in the United States incorporating either self-reported race or unknown race at the patient's discretion per hospital registration records.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Urologi och njurmedicin hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Urology and Nephrology hsv//eng
chronic kidney disease
glomerular filtration rate
serum creatinine

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Rule, Andrew D.Mayo Clinic Minnesota (author)
Schaeffner, ElkeCharité - University Medicine Berlin (author)
Cavalier, EtienneUniversity of Liège Hospital (author)
Shi, JunyanUniversity of British Columbia,University of Washington (author)
Hoofnagle, Andrew N.University of Washington,Washington University School of Medicine (author)
Nyman, UlfLund University,Lunds universitet,Diagnostisk radiologi, Malmö,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Radiology Diagnostics, Malmö,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments(Swepub:lu)ront-uny (author)
Björk, JonasLund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,LU profilområde: Naturbaserade framtidslösningar,Lunds universitets profilområden,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine,LU Profile Area: Nature-based future solutions,Lund University Profile areas,Skåne University Hospital(Swepub:lu)ymed-jbj (author)
Pottel, HansCatholic University of Leuven (author)
CHU NîmesUniversity of Liège Hospital (creator_code:org_t)

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In:Kidney International105:3, s. 629-6370085-2538

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By the author/editor: Delanaye, Pierre; Rule, Andrew D.; Schaeffner, Elke; Cavalier, Etienn ...; Shi, Junyan; Hoofnagle, Andre ...; show more...; Nyman, Ulf; Björk, Jonas; Pottel, Hans; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Urology and Neph ...

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