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Diabetic patients with acute coronary syndromes in contemporary European registries : Characteristics and outcomes
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- Lettino, Maddalena (author)
- Humanitas Research Hospital
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- Andell, Pontus (author)
- Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital
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- Zeymer, Uwe (author)
- Klinikum Ludwigshafen
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- Widimsky, Petr (author)
- Charles University in Prague
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- Danchin, Nicolas (author)
- Paris Descartes University
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Bardaji, Alfredo (author)
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- Barrabes, Jose A. (author)
- Vall d'Hebron University Hospital
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- Cequier, Angel (author)
- Bellvitge University Hospital-IDIBELL
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- Claeys, Marc J. (author)
- Antwerp University Hospital
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De Luca, Leonardo (author)
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Dörler, Jakob (author)
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- Erlinge, David (author)
- Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Molekylär kardiologi,Forskargrupper vid Lunds universitet,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Molecular Cardiology,Lund University Research Groups,Skåne University Hospital
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- Erne, Paul (author)
- University of Zurich
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- Goldstein, Patrick (author)
- University of Lille
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- Koul, Sasha M. (author)
- Lund University,Lunds universitet,Molekylär kardiologi,Forskargrupper vid Lunds universitet,Molecular Cardiology,Lund University Research Groups,Skåne University Hospital
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- Lemesle, Gilles (author)
- University of Lille
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- Lüscher, Thomas F. (author)
- University Hospital of Zurich
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- Matter, Christian M. (author)
- University Hospital of Zurich
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- Montalescot, Gilles (author)
- Pitié-Salpêtrière University Hospital
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- Radovanovic, Dragana (author)
- University of Zurich
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- Sendón, Jose Lopez (author)
- University Hospital La Paz
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Tousek, Petr (author)
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- Weidinger, Franz (author)
- Hospital Rudolfstiftung
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- Weston, Clive F.M. (author)
- Swansea University
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- Zaman, Azfar (author)
- Freeman Hospital
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- Li, Jin (author)
- University Hospital of Zurich
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- Jukema, J. Wouter (author)
- Leiden University Medical Centre
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(creator_code:org_t)
- 2017-03-10
- 2017
- English.
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In: European Heart Journal - Cardiovascular Pharmacotherapy. - : Oxford University Press (OUP). - 2055-6837 .- 2055-6845. ; 3:4, s. 198-213
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Abstract
Subject headings
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- Aims Among patients with acute coronary syndromes (ACS), those with diabetes mellitus (DM) are at particularly high risk of recurrent cardiovascular events and premature death. We aimed to provide a descriptive overview of unadjusted analyses of patient characteristics, ACS management, and outcomes up to 1 year after hospital admission for an ACS/index-ACS event, in patients with DM in contemporary registries in Europe. Methods and results A total of 10 registries provided data in a systematic manner on ACS patients with DM (total n =28 899), and without DM (total n= 97 505). In the DM population, the proportion of patients with ST-Segment Elevation Myocardial Infarction (STEMI) ranged from 22.1% to 64.6% (other patients had non-ST-Segment Elevation Myocardial Infarction (NSTEMI-ACS) or unstable angina). All-cause mortality in the registries ranged from 1.4% to 9.4% in-hospital; 2.8% to 7.9% at 30 days post-discharge; 5.1% to 10.7% at 180 days post-discharge; and 3.3% to 10.5% at 1 year post-discharge. Major bleeding events were reported in up to 3.8% of patients while in hospital (8 registries); up to 1.3% at 30 days (data from two registries only), and 2.0% at 1 year (one registry only). Registries differed substantially in terms of study setting, site, patient selection, definition and schedule of endpoints, and use of various P2Y12 inhibitors. In most, but not all, registries, event rates in DM patients were higher than in patients without DM. Pooled risk ratios comparing cohorts with DM vs. no DM were in-hospital significantly higher in DM for all-cause death (1.66; 95% CI 1.42-1.94), for cardiovascular death (2.33; 1.78 - 3.03), and for major bleeding (1.35; 1.21-1.52). Conclusion These registry data from real-life clinical practice confirm a high risk for recurrent events among DM patients with ACS, with great variation across the different registries.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Keyword
- Acute coronary syndromes
- Antiplatelets
- Clopidogrel
- Diabetes mellitus
- Non-ST-segment elevation
- Observational
- P2Y12 receptor inhibitors
- Prasugrel
- ST-segment elevation
- Ticagrelor
- Type 2 diabetes
- Unstable angina
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Lettino, Maddale ...
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Andell, Pontus
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Zeymer, Uwe
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Widimsky, Petr
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Danchin, Nicolas
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Bardaji, Alfredo
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show more...
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Barrabes, Jose A ...
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Cequier, Angel
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Claeys, Marc J.
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De Luca, Leonard ...
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Dörler, Jakob
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Erlinge, David
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Erne, Paul
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Goldstein, Patri ...
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Koul, Sasha M.
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Lemesle, Gilles
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Lüscher, Thomas ...
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Matter, Christia ...
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Montalescot, Gil ...
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Radovanovic, Dra ...
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Sendón, Jose Lop ...
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Tousek, Petr
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Weidinger, Franz
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Weston, Clive F. ...
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Zaman, Azfar
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Li, Jin
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Jukema, J. Woute ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
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European Heart J ...
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Lund University