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  • Lettino, MaddalenaHumanitas Research Hospital (author)

Diabetic patients with acute coronary syndromes in contemporary European registries : Characteristics and outcomes

  • Article/chapterEnglish2017

Publisher, publication year, extent ...

  • 2017-03-10
  • Oxford University Press (OUP),2017

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:04d2dcf7-6fab-4ab7-9f9d-7bf7b0a175ff
  • https://lup.lub.lu.se/record/04d2dcf7-6fab-4ab7-9f9d-7bf7b0a175ffURI
  • https://doi.org/10.1093/ehjcvp/pvw049DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Aims Among patients with acute coronary syndromes (ACS), those with diabetes mellitus (DM) are at particularly high risk of recurrent cardiovascular events and premature death. We aimed to provide a descriptive overview of unadjusted analyses of patient characteristics, ACS management, and outcomes up to 1 year after hospital admission for an ACS/index-ACS event, in patients with DM in contemporary registries in Europe. Methods and results A total of 10 registries provided data in a systematic manner on ACS patients with DM (total n =28 899), and without DM (total n= 97 505). In the DM population, the proportion of patients with ST-Segment Elevation Myocardial Infarction (STEMI) ranged from 22.1% to 64.6% (other patients had non-ST-Segment Elevation Myocardial Infarction (NSTEMI-ACS) or unstable angina). All-cause mortality in the registries ranged from 1.4% to 9.4% in-hospital; 2.8% to 7.9% at 30 days post-discharge; 5.1% to 10.7% at 180 days post-discharge; and 3.3% to 10.5% at 1 year post-discharge. Major bleeding events were reported in up to 3.8% of patients while in hospital (8 registries); up to 1.3% at 30 days (data from two registries only), and 2.0% at 1 year (one registry only). Registries differed substantially in terms of study setting, site, patient selection, definition and schedule of endpoints, and use of various P2Y12 inhibitors. In most, but not all, registries, event rates in DM patients were higher than in patients without DM. Pooled risk ratios comparing cohorts with DM vs. no DM were in-hospital significantly higher in DM for all-cause death (1.66; 95% CI 1.42-1.94), for cardiovascular death (2.33; 1.78 - 3.03), and for major bleeding (1.35; 1.21-1.52). Conclusion These registry data from real-life clinical practice confirm a high risk for recurrent events among DM patients with ACS, with great variation across the different registries.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Andell, PontusLund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital(Swepub:lu)med-poa (author)
  • Zeymer, UweKlinikum Ludwigshafen (author)
  • Widimsky, PetrCharles University in Prague (author)
  • Danchin, NicolasParis Descartes University (author)
  • Bardaji, Alfredo (author)
  • Barrabes, Jose A.Vall d'Hebron University Hospital (author)
  • Cequier, AngelBellvitge University Hospital-IDIBELL (author)
  • Claeys, Marc J.Antwerp University Hospital (author)
  • De Luca, Leonardo (author)
  • Dörler, Jakob (author)
  • Erlinge, DavidLund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Molekylär kardiologi,Forskargrupper vid Lunds universitet,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Molecular Cardiology,Lund University Research Groups,Skåne University Hospital(Swepub:lu)kard-der (author)
  • Erne, PaulUniversity of Zurich (author)
  • Goldstein, PatrickUniversity of Lille (author)
  • Koul, Sasha M.Lund University,Lunds universitet,Molekylär kardiologi,Forskargrupper vid Lunds universitet,Molecular Cardiology,Lund University Research Groups,Skåne University Hospital(Swepub:lu)med-sku (author)
  • Lemesle, GillesUniversity of Lille (author)
  • Lüscher, Thomas F.University Hospital of Zurich (author)
  • Matter, Christian M.University Hospital of Zurich (author)
  • Montalescot, GillesPitié-Salpêtrière University Hospital (author)
  • Radovanovic, DraganaUniversity of Zurich (author)
  • Sendón, Jose LopezUniversity Hospital La Paz (author)
  • Tousek, Petr (author)
  • Weidinger, FranzHospital Rudolfstiftung (author)
  • Weston, Clive F.M.Swansea University (author)
  • Zaman, AzfarFreeman Hospital (author)
  • Li, JinUniversity Hospital of Zurich (author)
  • Jukema, J. WouterLeiden University Medical Centre (author)
  • Humanitas Research HospitalKardiologi (creator_code:org_t)

Related titles

  • In:European Heart Journal - Cardiovascular Pharmacotherapy: Oxford University Press (OUP)3:4, s. 198-2132055-68372055-6845

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