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  • Little, JayneChristie NHS Foundation Trust,University of Manchester (author)

Glucocorticoid use and factors associated with variability in this use in the Systemic Lupus International Collaborating Clinics Inception Cohort

  • Article/chapterEnglish2018

Publisher, publication year, extent ...

  • 2018-01-18
  • Oxford University Press (OUP),2018
  • 11 s.

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:04e51085-6ebc-4e82-9279-ab6ed59c12e7
  • https://lup.lub.lu.se/record/04e51085-6ebc-4e82-9279-ab6ed59c12e7URI
  • https://doi.org/10.1093/rheumatology/kex444DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:137952894URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Objectives. To describe glucocorticoid (GC) use in the SLICC inception cohort and to explore factors associated with GC use. In particular we aimed to assess temporal trends in GC use and to what extent physician-related factors may influence use. Methods. Patients were recruited within 15 months of diagnosis of SLE from 33 centres between 1999 and 2011 and continue to be reviewed annually. Descriptive statistics were used to detail oral and parenteral GC use. Cross sectional and longitudinal analyses were performed to explore factors associated with GC use at enrolment and over time. Results. We studied 1700 patients with a mean (S.D.) follow-up duration of 7.26 (3.82) years. Over the entire study period, 1365 (81.3%) patients received oral GCs and 447 (26.3%) received parenteral GCs at some point. GC use was strongly associated with treatment centre, age, race/ethnicity, sex, disease duration and disease activity. There was no change in the proportion of patients on GCs or the average doses of GC used over time according to year of diagnosis. Conclusion. GCs remain a cornerstone in SLE management and there have been no significant changes in their use over the past 10-15 years. While patient and disease factors contribute to the variation in GC use, between-centre differences suggest that physician-related factors also contribute. Evidence-based treatment algorithms are needed to inform a more standardized approach to GC use in SLE.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Parker, BenChristie NHS Foundation Trust (author)
  • Lunt, MarkUniversity of Manchester (author)
  • Hanly, John G.Dalhousie University (author)
  • Urowitz, Murray B.University of Toronto (author)
  • Clarke, Ann E.University of Calgary (author)
  • Romero-Diaz, JuanitaInstituto Nacional de Ciencias Médicas y Nutrición (author)
  • Gordon, CarolineUniversity of Birmingham,City Hospital, Birmingham (author)
  • Bae, Sang CheolHanyang University (author)
  • Bernatsky, SashaMcGill University Health Center (author)
  • Wallace, Daniel J.University of California, Los Angeles (author)
  • Merrill, Joan T.Oklahoma Medical Research Foundation (author)
  • Buyon, JillNew York University (author)
  • Isenberg, David A.University College London,NYU Hospital for Joint Diseases (author)
  • Rahman, AnisurUniversity College London (author)
  • Ginzler, Ellen M.SUNY Downstate Health Sciences University,Feinstein Institute for Medical Research (author)
  • Petri, MichelleJohns Hopkins University School of Medicine (author)
  • Dooley, Mary AnneUniversity of North Carolina (author)
  • Fortin, PaulCentre hospitalier universitaire de Québec (author)
  • Gladman, Dafna D.University of Toronto (author)
  • Steinsson, KristjanNational University Hospital of Iceland (author)
  • Ramsey-Goldman, RosalindNorthwestern University Feinberg School of Medicine (author)
  • Khamashta, Munther A.King's College London (author)
  • Aranow, CynthiaFeinstein Institute for Medical Research (author)
  • Mackay, MegganFeinstein Institute for Medical Research (author)
  • Alarcón, Graciela S.University of Alabama (author)
  • Manzi, SusanAllegheny Health Network (author)
  • Nived, OlaLund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)reum-oni (author)
  • Jönsen, AndreasLund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)reum-ajo (author)
  • Zoma, Asad A.Hairmyres Hospital (author)
  • van Vollenhoven, Ronald F.Karolinska Institutet,Karolinska Institute (author)
  • Ramos-Casals, ManuelHospital Clínic of Barcelona (author)
  • Ruiz-Irastorza, GuillermoUniversity of the Basque Country (author)
  • Lim, Sung SamEmory University (author)
  • Kalunian, Kenneth C.University of California, San Diego (author)
  • Inanc, MuratIstanbul University (author)
  • Kamen, Diane L.Medical University of South Carolina (author)
  • Peschken, Christine A.University of Manitoba (author)
  • Jacobsen, SorenCopenhagen University Hospital (author)
  • Askanase, AncaNYU Hospital for Joint Diseases (author)
  • Sanchez-Guerrero, JorgeUniversity of Toronto (author)
  • Bruce, Ian N.University of Manchester,Christie NHS Foundation Trust (author)
  • Christie NHS Foundation TrustUniversity of Manchester (creator_code:org_t)

Related titles

  • In:Rheumatology (United Kingdom): Oxford University Press (OUP)57:4, s. 677-6871462-03241462-0332

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