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Glucocorticoid use ...
Glucocorticoid use and factors associated with variability in this use in the Systemic Lupus International Collaborating Clinics Inception Cohort
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- Little, Jayne (författare)
- Christie NHS Foundation Trust,University of Manchester
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- Parker, Ben (författare)
- Christie NHS Foundation Trust
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- Lunt, Mark (författare)
- University of Manchester
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- Hanly, John G. (författare)
- Dalhousie University
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- Urowitz, Murray B. (författare)
- University of Toronto
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- Clarke, Ann E. (författare)
- University of Calgary
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- Romero-Diaz, Juanita (författare)
- Instituto Nacional de Ciencias Médicas y Nutrición
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- Gordon, Caroline (författare)
- University of Birmingham,City Hospital, Birmingham
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- Bae, Sang Cheol (författare)
- Hanyang University
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- Bernatsky, Sasha (författare)
- McGill University Health Center
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- Wallace, Daniel J. (författare)
- University of California, Los Angeles
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- Merrill, Joan T. (författare)
- Oklahoma Medical Research Foundation
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- Buyon, Jill (författare)
- New York University
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- Isenberg, David A. (författare)
- University College London,NYU Hospital for Joint Diseases
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- Rahman, Anisur (författare)
- University College London
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- Ginzler, Ellen M. (författare)
- SUNY Downstate Health Sciences University,Feinstein Institute for Medical Research
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- Petri, Michelle (författare)
- Johns Hopkins University School of Medicine
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- Dooley, Mary Anne (författare)
- University of North Carolina
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- Fortin, Paul (författare)
- Centre hospitalier universitaire de Québec
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- Gladman, Dafna D. (författare)
- University of Toronto
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- Steinsson, Kristjan (författare)
- National University Hospital of Iceland
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- Ramsey-Goldman, Rosalind (författare)
- Northwestern University Feinberg School of Medicine
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- Khamashta, Munther A. (författare)
- King's College London
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- Aranow, Cynthia (författare)
- Feinstein Institute for Medical Research
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- Mackay, Meggan (författare)
- Feinstein Institute for Medical Research
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- Alarcón, Graciela S. (författare)
- University of Alabama
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- Manzi, Susan (författare)
- Allegheny Health Network
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- Nived, Ola (författare)
- Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Jönsen, Andreas (författare)
- Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Zoma, Asad A. (författare)
- Hairmyres Hospital
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- van Vollenhoven, Ronald F. (författare)
- Karolinska Institutet,Karolinska Institute
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- Ramos-Casals, Manuel (författare)
- Hospital Clínic of Barcelona
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- Ruiz-Irastorza, Guillermo (författare)
- University of the Basque Country
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- Lim, Sung Sam (författare)
- Emory University
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- Kalunian, Kenneth C. (författare)
- University of California, San Diego
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- Inanc, Murat (författare)
- Istanbul University
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- Kamen, Diane L. (författare)
- Medical University of South Carolina
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- Peschken, Christine A. (författare)
- University of Manitoba
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- Jacobsen, Soren (författare)
- Copenhagen University Hospital
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- Askanase, Anca (författare)
- NYU Hospital for Joint Diseases
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- Sanchez-Guerrero, Jorge (författare)
- University of Toronto
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- Bruce, Ian N. (författare)
- University of Manchester,Christie NHS Foundation Trust
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(creator_code:org_t)
- 2018-01-18
- 2018
- Engelska 11 s.
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Ingår i: Rheumatology (United Kingdom). - : Oxford University Press (OUP). - 1462-0324 .- 1462-0332. ; 57:4, s. 677-687
- Relaterad länk:
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http://dx.doi.org/10...
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https://academic.oup...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Objectives. To describe glucocorticoid (GC) use in the SLICC inception cohort and to explore factors associated with GC use. In particular we aimed to assess temporal trends in GC use and to what extent physician-related factors may influence use. Methods. Patients were recruited within 15 months of diagnosis of SLE from 33 centres between 1999 and 2011 and continue to be reviewed annually. Descriptive statistics were used to detail oral and parenteral GC use. Cross sectional and longitudinal analyses were performed to explore factors associated with GC use at enrolment and over time. Results. We studied 1700 patients with a mean (S.D.) follow-up duration of 7.26 (3.82) years. Over the entire study period, 1365 (81.3%) patients received oral GCs and 447 (26.3%) received parenteral GCs at some point. GC use was strongly associated with treatment centre, age, race/ethnicity, sex, disease duration and disease activity. There was no change in the proportion of patients on GCs or the average doses of GC used over time according to year of diagnosis. Conclusion. GCs remain a cornerstone in SLE management and there have been no significant changes in their use over the past 10-15 years. While patient and disease factors contribute to the variation in GC use, between-centre differences suggest that physician-related factors also contribute. Evidence-based treatment algorithms are needed to inform a more standardized approach to GC use in SLE.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Nyckelord
- Epidemiology
- Glucocorticoids
- Systemic lupus erythematosus
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- art (ämneskategori)
- ref (ämneskategori)
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Little, Jayne
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Parker, Ben
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Lunt, Mark
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Hanly, John G.
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Urowitz, Murray ...
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Clarke, Ann E.
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Romero-Diaz, Jua ...
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Gordon, Caroline
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Bae, Sang Cheol
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Bernatsky, Sasha
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Wallace, Daniel ...
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Merrill, Joan T.
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Buyon, Jill
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Isenberg, David ...
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Rahman, Anisur
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Ginzler, Ellen M ...
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Petri, Michelle
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Dooley, Mary Ann ...
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Fortin, Paul
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Gladman, Dafna D ...
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Steinsson, Krist ...
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Ramsey-Goldman, ...
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Khamashta, Munth ...
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Aranow, Cynthia
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Mackay, Meggan
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Alarcón, Graciel ...
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Manzi, Susan
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Nived, Ola
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Jönsen, Andreas
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Zoma, Asad A.
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van Vollenhoven, ...
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Ramos-Casals, Ma ...
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Ruiz-Irastorza, ...
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Lim, Sung Sam
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Kalunian, Kennet ...
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Inanc, Murat
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Kamen, Diane L.
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Peschken, Christ ...
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Jacobsen, Soren
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Askanase, Anca
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Sanchez-Guerrero ...
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Bruce, Ian N.
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Lunds universitet
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Karolinska Institutet