Neuropeptide Y : prejunctional inhibition of vagally induced contractions in the guinea pig trachea

• The effects of neuropeptide Y (NPY) on the contractile response to vagus nerve stimulation at different frequencies was studied in an isolated tracheal tube preparation from guinea pig. NPY had no effect on basal smooth muscle tension or on the contractile effect of carbachol, but inhibited vagally induced contractions in a concentration-dependent manner with a greater inhibition at low frequencies than at high. We suggest that the effect is exerted prejunctionally.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)

Keyword

Animals

Carbachol/pharmacology

Dose-Response Relationship, Drug

Electric Stimulation

Guinea Pigs

Male

Muscle Contraction/drug effects

Muscle, Smooth/drug effects

Neuropeptide Y/pharmacology

Trachea/drug effects

Vagus Nerve/drug effects

Publication and Content Type

art (subject category)

ref (subject category)