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Diagnosing and Mapp...
Diagnosing and Mapping Pulmonary Emphysema on X-Ray Projection Images: Incremental Value of Grating-Based X-Ray Dark-Field Imaging
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Meinel, Felix G. (författare)
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Schwab, Felix (författare)
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Schleede, Simone (författare)
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- Bech, Martin (författare)
- Lund University,Lunds universitet,Medicinsk strålningsfysik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medical Radiation Physics, Lund,Section V,Department of Clinical Sciences, Lund,Faculty of Medicine
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Herzen, Julia (författare)
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Achterhold, Klaus (författare)
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Auweter, Sigrid (författare)
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Bamberg, Fabian (författare)
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Yildirim, Ali Oe. (författare)
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Bohla, Alexander (författare)
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Eickelberg, Oliver (författare)
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Loewen, Rod (författare)
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Gifford, Martin (författare)
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Ruth, Ronald (författare)
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Reiser, Maximilian F. (författare)
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Pfeiffer, Franz (författare)
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Nikolaou, Konstantin (författare)
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(creator_code:org_t)
- 2013-03-26
- 2013
- Engelska.
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Ingår i: PLoS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 8:3
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Abstract
Ämnesord
Stäng
- Purpose: To assess whether grating-based X-ray dark-field imaging can increase the sensitivity of X-ray projection images in the diagnosis of pulmonary emphysema and allow for a more accurate assessment of emphysema distribution. Materials and Methods: Lungs from three mice with pulmonary emphysema and three healthy mice were imaged ex vivo using a laser-driven compact synchrotron X-ray source. Median signal intensities of transmission (T), dark-field (V) and a combined parameter (normalized scatter) were compared between emphysema and control group. To determine the diagnostic value of each parameter in differentiating between healthy and emphysematous lung tissue, a receiver-operating-characteristic (ROC) curve analysis was performed both on a per-pixel and a per-individual basis. Parametric maps of emphysema distribution were generated using transmission, dark-field and normalized scatter signal and correlated with histopathology. Results: Transmission values relative to water were higher for emphysematous lungs than for control lungs (1.11 vs. 1.06, p<0.001). There was no difference in median dark-field signal intensities between both groups (0.66 vs. 0.66). Median normalized scatter was significantly lower in the emphysematous lungs compared to controls (4.9 vs. 10.8, p<0.001), and was the best parameter for differentiation of healthy vs. emphysematous lung tissue. In a per-pixel analysis, the area under the ROC curve (AUC) for the normalized scatter value was significantly higher than for transmission (0.86 vs. 0.78, p<0.001) and dark-field value (0.86 vs. 0.52, p<0.001) alone. Normalized scatter showed very high sensitivity for a wide range of specificity values (94% sensitivity at 75% specificity). Using the normalized scatter signal to display the regional distribution of emphysema provides color-coded parametric maps, which show the best correlation with histopathology. Conclusion: In a murine model, the complementary information provided by X-ray transmission and dark-field images adds incremental diagnostic value in detecting pulmonary emphysema and visualizing its regional distribution as compared to conventional X-ray projections.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
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Meinel, Felix G.
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Schwab, Felix
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Schleede, Simone
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Bech, Martin
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Herzen, Julia
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Achterhold, Klau ...
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visa fler...
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Auweter, Sigrid
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Bamberg, Fabian
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Yildirim, Ali Oe ...
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Bohla, Alexander
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Eickelberg, Oliv ...
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Loewen, Rod
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Gifford, Martin
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Ruth, Ronald
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Reiser, Maximili ...
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Pfeiffer, Franz
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Nikolaou, Konsta ...
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visa färre...
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