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Characteristics of ...
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Mahdi, TalalThe Ottawa Hospital,University of Toronto
(författare)
Characteristics of Lymphoproliferative Disorders with More Than One Aberrant Cell Population as Detected by 10-Color Flow Cytometry
- Artikel/kapitelEngelska2018
Förlag, utgivningsår, omfång ...
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2016-08-18
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Wiley,2018
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9 s.
Nummerbeteckningar
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LIBRIS-ID:oai:lup.lub.lu.se:05978a3c-174d-4bf4-b3af-0e5756c7f833
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https://lup.lub.lu.se/record/05978a3c-174d-4bf4-b3af-0e5756c7f833URI
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https://doi.org/10.1002/cyto.b.21402DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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Ämneskategori:ref swepub-contenttype
Anmärkningar
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Background: We have evaluated the frequency of lymphoproliferative disorders with more than one aberrant population of monotypic B-cells detected during routine hematopathological diagnostics. Materials and Methods: 2600 samples peripheral (blood, bone marrow, fine-needle aspirate, lymph node, and pleural fluid cell suspensions) were analyzed using a 10-color B-cell panel and a 10-color T-cell panel. A 10-color plasma cell/lymphoplasmacytic panel was performed when appropriate. Results: 790/2600 samples (30%) showed at least one aberrant B-cell population and 27(1%) showed an aberrant T-cell population. 41/790 samples (5.1%) showed two aberrant B-cell populations. Thirteen patients had two B-cell populations with different surface immunoglobulin restriction (one kappa+ and one lambda+), most with B-cell chronic lymphocytic leukemia-related phenotype. Five cases showed two B-cell populations with the same light chain restriction but distinctly different immunophenotypes. In 23 cases, two populations had the same light chain restriction and differed by expression of one or 2 markers, thus, a possibility of intraclonal differentiation could not be excluded. Cases with possible intraclonal differentiation had a significantly higher proportion of aberrant B-cells than those with two coexisting aberrant B-cell populations (49.9% vs. 27.7%, p = 0.008). In only one sample one population of clonal B-cell and one clonal T-cell population with large granular lymphocyte related phenotype were found. Conclusion: Using our panels 5.1% of cases with lymphoproliferative disorder-associated aberrant findings show two aberrant (clonal) lymphoid and/or plasma cell populations.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Rajab, AmrUniversity of Toronto
(författare)
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Padmore, RuthThe Ottawa Hospital
(författare)
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Porwit, AnnaLund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,University of Toronto(Swepub:lu)an6742po
(författare)
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The Ottawa HospitalUniversity of Toronto
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Cytometry Part B - Clinical Cytometry: Wiley94:2, s. 230-2381552-4949
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