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- Le, Thi LisaUniversity of Copenhagen,Glostrup Hospital (författare)
CGRP in rat mesenteric artery and vein - receptor expression, CGRP presence and potential roles
- Artikel/kapitelEngelska2020
Förlag, utgivningsår, omfång ...
- Elsevier BV,2020
Nummerbeteckningar
- LIBRIS-ID:oai:lup.lub.lu.se:05c31b44-b8ad-44f0-8e1e-3a27dd0c300d
- https://lup.lub.lu.se/record/05c31b44-b8ad-44f0-8e1e-3a27dd0c300dURI
- https://doi.org/10.1016/j.ejphar.2020.173033DOI
Kompletterande språkuppgifter
- Språk:engelska
- Sammanfattning på:engelska
Ingår i deldatabas
- SwePubSwePub
Klassifikation
Anmärkningar
- CGRP is a potent dilator of arteries and despite rich perivascular CGRP immunoreactivity in both arteries and veins the role of CGRP in veins remains unknown. The aim of the current study was to compare perivascular CGRP immunoreactivity and expression of CGRP receptor mRNA and CGRP receptor immunoreactivity in rat mesenteric arteries and veins. Furthermore, potential vasomotor effects of CGRP were explored in veins. Immunohistochemical studies reproduced rich perivascular CGRP innervation in arteries and in veins. Further, the presence of mRNA encoding the CGRP receptor subunits, CLR and RAMP1, were demonstrated in both arteries and veins using qPCR. Before comparing the vasoactive effects of CGRP in arteries and veins, we aimed to identify an experimental setting where vasomotor responses could be detected. Therefore, a length-tension study was performed in artery and vein segments. Whereas the arteries showed the characteristic monophasic curve with an IC/IC100 value of 0.9, surprisingly the veins showed a biphasic response with two corresponding IC/IC100 values of 0.7 and 0.9, respectively. There was no significant difference between fresh and cultured vasculature segments. To investigate whether a potential tension-dependent CGRP-induced dilation of veins caused the decline between the two IC/IC100 peaks, a second study was performed, with the CGRP receptor antagonist, BIBN4096BS (olcegepant) and the sensory nerve secretagogue, capsaicin. No significant vascular role of endogenous perivascular CGRP in mesenteric veins could be concluded, and a potential role of the rich perivascular CGRP and CGRP receptor abundancy in veins remains unknown.
Ämnesord och genrebeteckningar
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Farmakologi och toxikologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Pharmacology and Toxicology hsv//eng
- Artery
- CGRP
- Immunohistochemistry
- Length-tension
- qPCR
- Vein
Biuppslag (personer, institutioner, konferenser, titlar ...)
- Grell, Anne SofieGlostrup Hospital(Swepub:lu)med-aog (författare)
- Sheykhzade, MajidUniversity of Copenhagen (författare)
- Warfvinge, KarinLund University,Lunds universitet,Medicin/akutsjukvård, Lund,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medicine, Lund,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Glostrup Hospital(Swepub:lu)oft-kwa (författare)
- Edvinsson, LarsLund University,Lunds universitet,Experimentell kärlforskning,Forskargrupper vid Lunds universitet,Experimental Vascular Research,Lund University Research Groups,Glostrup Hospital(Swepub:lu)med-led (författare)
- Sams, AnetteGlostrup Hospital (författare)
- University of CopenhagenGlostrup Hospital (creator_code:org_t)
Sammanhörande titlar
- Ingår i:European Journal of Pharmacology: Elsevier BV8750014-2999
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- European Journal of Pharmacology (Sök värdpublikationen i LIBRIS)
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- Warfvinge, Karin
- Edvinsson, Lars
- Sams, Anette
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