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Plasma Vitamin C an...
Plasma Vitamin C and type 2 diabetes : Genome-wide association study and mendelian randomization analysis in European populations
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- Zheng, Ju Sheng (author)
- Medical Research Council Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom; Key Laboratory of Growth Regulation and Translational Research of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou, China,Westlake University
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- Luan, Jian’An (author)
- Medical Research Council Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom
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- Sofianopoulou, Eleni (author)
- British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cam-bridge, United Kingdom
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- Imamura, Fumiaki (author)
- Medical Research Council Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom
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- Stewart, Isobel D. (author)
- Medical Research Council Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom
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- Day, Felix R. (author)
- Medical Research Council Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom
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- Pietzner, Maik (author)
- Medical Research Council Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom
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- Wheeler, Eleanor (author)
- Medical Research Council Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom
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- Lotta, Luca A. (author)
- Medical Research Council Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom
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- Gundersen, Thomas E. (author)
- Vitas AS,Vitas Ltd, Oslo, Norway
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- Amiano, Pilar (author)
- Ministry of Health of the Basque Government, Public Health Division of Gipuzkoa, Biodonostia Health Research Institute, Donostia-San Sebas-tian, Spain
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- Ardanaz, Eva (author)
- Navarra Public Health Institute, Pamplona, Spain; IdiSNA, Navarra Institute for Health Research, Pamplona, Spain; CIBER in Epidemiology and Public Health (CI-BERESP), Madrid, Spain,Health Research Institute of Navarra (IDISNA),CIBER Epidemiology and Public Health (CIBERESP)
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- Chirlaque, María Dolores (author)
- CIBER in Epidemiology and Public Health (CI-BERESP), Madrid, Spain; Department of Epidemiology, Regional Health Council, Instituto Murciano de Investigatión Bio-sanitaria (IMIB)-Arrixaca, Murcia University, Mur-cia, Spain,University of Murcia
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- Fagherazzi, Guy (author)
- Digital Epidemiology and e-Health Research Hub, Department of Population Health, Luxembourg Institute of Health, Strassen, Luxembourg, France; Center of Epidemiology and Population Health, UMR 1018, INSERM, Paris South-Paris Saclay University, Gustave Roussy Institute, Villejuif, France,Luxembourg Institute of Health,Institut Gustave Roussy
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- Franks, Paul W. (author)
- Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups,Department of Clinical Sciences, Lund Univer-sity, Malmö, Sweden
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- Kaaks, Rudolf (author)
- Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
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- Laouali, Nasser (author)
- Center of Epidemiology and Population Health, UMR 1018, INSERM, Paris South-Paris Saclay University, Gustave Roussy Institute, Villejuif, France,Institut Gustave Roussy
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- Mancini, Francesca Romana (author)
- Center of Epidemiology and Population Health, UMR 1018, INSERM, Paris South-Paris Saclay University, Gustave Roussy Institute, Villejuif, France,University of Paris-Saclay
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- Nilsson, Peter M. (author)
- Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups,Department of Clinical Sciences, Lund Univer-sity, Malmö, Sweden
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- Charlotte Onland-Moret, N. (author)
- Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands,University Medical Center Utrecht
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- Olsen, Anja (author)
- Danish Cancer Society Research Center, Copen-hagen, Denmark; Department of Public Health, Aarhus Univer-sity, Aarhus, Denmark,Aarhus University
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- Overvad, Kim (author)
- Department of Public Health, Aarhus Univer-sity, Aarhus, Denmark; Department of Cardiology, Aalborg University Hospital, Aarhus, Denmark,Aarhus University
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- Panico, Salvatore (author)
- Dipartimento di Medicina Clinica e Chirurgia, Federico II University, Naples, Italy
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- Palli, Domenico (author)
- Cancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network-ISPRO, Florence, Italy
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- Ricceri, Fulvio (author)
- Azienda Sanitaria Locale Torino 3,Department of Clinical and Biological Sciences, University of Turin, Turin, Orbassano, Italy; Unit of Epidemiology, Regional Health Service ASL TO3, Turin, Grugliasco, Italy
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- Rolandsson, Olov (author)
- Umeå universitet,Umeå University,Allmänmedicin
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- Spijkerman, Annemieke M.W. (author)
- National Institute for Public Health and the Environment (RIVM), Bilthoven, Netherlands
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- Sánchez, María José (author)
- Andalusian School Of Public Health (EASP),Andalusian School of Public Health, Granada, Spain
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- Schulze, Matthias B. (author)
- Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany; German Center for Diabetes Research (DZD), München-Neuherberg, Germany; Institute of Nutrition Science, University of Potsdam, Nuthetal, Germany,University of Potsdam,German Institute of Human Nutrition
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- Sala, Núria (author)
- Unit of Nutrition and Cancer, Cancer Epidemiology Research Program and Translational Research Laboratory, Catalan Institute of Oncology-ICO, Group of Research on Nutrition and Cancer, Bellvitge Biomedical Research Institute (IDIBELL), L’Hospitalet of Llobregat, Barcelona, Spain,L'Hospitalet de Llobregat, Barcelona,Catalan Institute of Oncology
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- Sieri, Sabina (author)
- Epidemiology and Prevention Unit, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Istituto Nazionale dei Tumori di Milano Via Venezian, Milan, Italy,British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cam-bridge, United Kingdom; National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics, University of Cambridge, Cambridge, United Kingdom; Department of Human Genetics, Wellcome Sanger Institute, Hinxton, United Kingdom; National Institute for Health Research Cambridge Biomedical Research Center, University of Cambridge and Cambridge University Hospitals, Cambridge, United Kingdom; Health Data Research UK Cambridge, Well-come Genome Campus and University of Cam-bridge, Cambridge, United Kingdom,Wellcome Trust Sanger Institute
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- Tjønneland, Anne (author)
- Department of Public Health, Aarhus Univer-sity, Aarhus, Denmark; Institute of Public Health, University of Copen-hagen, Copenhagen, Denmark,University of Copenhagen
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- Tumino, Rosario (author)
- Civic and M.P Arezzo Hospital,Cancer Registry and Histopathology Depart-ment, Azienda Sanitaria Provinciale (ASP), Ra-gusa, Italy
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- van der Schouw, Yvonne T. (author)
- Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands,University Medical Center Utrecht
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- Weiderpass, Elisabete (author)
- International Agency for Research on Cancer, World Health Organization,International Agency for Research on Cancer, Lyon, France
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- Riboli, Elio (author)
- School of Public Health, Imperial College, London, United Kingdom
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- Danesh, John (author)
- British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cam-bridge, United Kingdom; National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics, University of Cambridge, Cambridge, United Kingdom; British Heart Foundation Center of Research Excellence, University of Cambridge, Cambridge, United Kingdom; Department of Human Genetics, Wellcome Sanger Institute, Hinxton, United Kingdom; National Institute for Health Research Cambridge Biomedical Research Center, University of Cambridge and Cambridge University Hospitals, Cambridge, United Kingdom; Health Data Research UK Cambridge, Well-come Genome Campus and University of Cam-bridge, Cambridge, United Kingdom,Wellcome Trust Sanger Institute
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- Butterworth, Adam S. (author)
- University of Cambridge,Wellcome Trust Sanger Institute
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- Sharp, Stephen J. (author)
- Medical Research Council Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom
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- Langenberg, Claudia (author)
- Medical Research Council Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom
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- Forouhi, Nita G. (author)
- Medical Research Council Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom
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- Wareham, Nicholas J. (author)
- Medical Research Council Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom
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(creator_code:org_t)
- 2020-11-17
- 2021
- English 9 s.
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In: Diabetes Care. - : American Diabetes Association. - 0149-5992 .- 1935-5548. ; 44:1, s. 98-106
- Related links:
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http://dx.doi.org/10...
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https://care.diabete...
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https://lup.lub.lu.s...
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https://doi.org/10.2...
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https://urn.kb.se/re...
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Abstract
Subject headings
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- OBJECTIVE Higher plasma vitamin C levels are associated with lower type 2 diabetes risk, but whether this association is causal is uncertain. To investigate this, we studied the association of genetically predicted plasma vitamin C with type 2 diabetes. RESEARCH DESIGN AND METHODS We conducted genome-wide association studies of plasma vitamin C among 52,018 individuals of European ancestry to discover novel genetic variants. We performed Mendelian randomization analyses to estimate the association of genetically predicted differences in plasma vitamin C with type 2 diabetes in up to 80,983 case participants and 842,909 noncase participants. We compared this estimate with the observational association between plasma vitamin C and incident type 2 diabetes, including 8,133 case participants and 11,073 noncase participants. RESULTS We identified 11 genomic regions associated with plasma vitamin C (P < 5 ☓ 10-8), with the strongest signal at SLC23A1, and 10 novel genetic loci including SLC23A3, CHPT1, BCAS3, SNRPF, RER1, MAF, GSTA5, RGS14, AKT1, and FADS1. Plasma vitamin C was inversely associated with type 2 diabetes (hazard ratio per SD 0.88; 95% CI 0.82, 0.94), but there was no association between genetically predicted plasma vitamin C (excluding FADS1 variant due to its apparent pleiotropic effect) and type 2 diabetes (1.03; 95% CI 0.96, 1.10). CONCLUSIONS These findings indicate discordance between biochemically measured and genetically predicted plasma vitamin C levels in the association with type 2 diabetes among European populations. The null Mendelian randomization findings provide no strong evidence to suggest the use of vitamin C supplementation for type 2 diabetes prevention.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
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- By the author/editor
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Zheng, Ju Sheng
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Luan, Jian’An
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Sofianopoulou, E ...
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Imamura, Fumiaki
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Stewart, Isobel ...
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Day, Felix R.
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show more...
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Pietzner, Maik
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Wheeler, Eleanor
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Lotta, Luca A.
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Gundersen, Thoma ...
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Amiano, Pilar
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Ardanaz, Eva
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Chirlaque, María ...
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Fagherazzi, Guy
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Franks, Paul W.
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Kaaks, Rudolf
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Laouali, Nasser
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Mancini, Frances ...
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Nilsson, Peter M ...
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Charlotte Onland ...
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Olsen, Anja
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Overvad, Kim
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Panico, Salvator ...
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Palli, Domenico
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Ricceri, Fulvio
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Rolandsson, Olov
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Spijkerman, Anne ...
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Sánchez, María J ...
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Schulze, Matthia ...
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Sala, Núria
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Sieri, Sabina
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Tjønneland, Anne
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Tumino, Rosario
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van der Schouw, ...
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Weiderpass, Elis ...
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Riboli, Elio
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Danesh, John
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Butterworth, Ada ...
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Sharp, Stephen J ...
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Langenberg, Clau ...
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Forouhi, Nita G.
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Wareham, Nichola ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
- Articles in the publication
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Diabetes Care
- By the university
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Lund University
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Umeå University