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A 7-gene signature ...
A 7-gene signature depicts the biochemical profile of early prefibrotic myelofibrosis
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- Skov, Vibe (author)
- Zealand University Hospital
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- Burton, Mark (author)
- Odense University Hospital
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- Thomassen, Mads (author)
- Odense University Hospital
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- Larsen, Thomas Stauffer (author)
- Odense University Hospital
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- Riley, Caroline H. (author)
- Zealand University Hospital
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- Madelung, Ann Brinch (author)
- Naestved Hospital
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- Kjær, Lasse (author)
- Zealand University Hospital
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- Bondo, Henrik (author)
- Naestved Hospital
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- Stamp, Inger (author)
- Naestved Hospital
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- Ehinger, Mats (author)
- Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Dahl-Sørensen, Rasmus (author)
- Zealand University Hospital
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- Brochmann, Nana (author)
- Zealand University Hospital
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- Nielsen, Karsten (author)
- Aarhus University
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- Thiele, Jürgen (author)
- University of Cologne
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- Jensen, Morten K. (author)
- Zealand University Hospital
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- Bjerrum, Ole Weis (author)
- University of Copenhagen
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- Kruse, Torben A. (author)
- Odense University Hospital
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- Hasselbalch, Hans Carl (author)
- Zealand University Hospital
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(creator_code:org_t)
- 2016-08-31
- 2016
- English.
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In: PLoS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 11:8
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Abstract
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- Recent studies have shown that a large proportion of patients classified as essential thrombocythemia (ET) actually have early primary prefibrotic myelofibrosis (prePMF), which implies an inferior prognosis as compared to patients being diagnosed with so-called genuine or true ET. According to theWorld Health Organization (WHO) 2008 classification, bone marrow histology is a major component in the distinction between these disease entities. However, the differential diagnosis between themmay be challenging and several studies have not been able to distinguish between them.Most lately, it has been argued that simple blood tests, including the leukocyte count and plasma lactate dehydrogenase (LDH) may be useful tools to separate genuine ET from prePMF, the latter disease entity more often being featured by anemia, leukocytosis and elevated LDH.Whole blood gene expression profiling was performed in 17 and 9 patients diagnosed with ET and PMF, respectively. Using elevated LDH obtained at the time of diagnosis as a marker of prePMF, a 7-gene signature was identified which correctly predicted the prePMF group with a sensitivity of 100%and a specificity of 89%. The 7 genes included MPO, CEACAM8, CRISP3, MS4A3, CEACAM6, HEMGN, andMMP8, which are genes known to be involved in inflammation, cell adhesion, differentiation and proliferation. Evaluation of bone marrow biopsies and the 7-gene signature showed a concordance rate of 71%, 79%, 62%, and 38%. Our 7-gene signature may be a useful tool to differentiate between genuine ET and prePMF but needs to be validated in a larger cohort of "ET" patients.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
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- By the author/editor
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Skov, Vibe
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Burton, Mark
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Thomassen, Mads
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Larsen, Thomas S ...
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Riley, Caroline ...
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Madelung, Ann Br ...
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Kjær, Lasse
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Bondo, Henrik
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Stamp, Inger
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Ehinger, Mats
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Dahl-Sørensen, R ...
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Brochmann, Nana
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Nielsen, Karsten
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Thiele, Jürgen
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Jensen, Morten K ...
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Bjerrum, Ole Wei ...
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Kruse, Torben A.
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Hasselbalch, Han ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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PLoS ONE
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Lund University