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Amyloid PET and cog...
Amyloid PET and cognitive decline in cognitively normal individuals : the SCIENCe project
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- Timmers, Tessa (author)
- Academic Medical Center of University of Amsterdam (AMC)
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- Ossenkoppele, Rik (author)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Academic Medical Center of University of Amsterdam (AMC)
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- Verfaillie, Sander C.J. (author)
- Academic Medical Center of University of Amsterdam (AMC)
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- van der Weijden, Chris W.J. (author)
- Academic Medical Center of University of Amsterdam (AMC)
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- Slot, Rosalinde E.R. (author)
- Academic Medical Center of University of Amsterdam (AMC)
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- Wesselman, Linda M.P. (author)
- Academic Medical Center of University of Amsterdam (AMC)
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- Windhorst, Albert D. (author)
- Academic Medical Center of University of Amsterdam (AMC)
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- Wolters, Emma E. (author)
- Academic Medical Center of University of Amsterdam (AMC)
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- Yaqub, Maqsood (author)
- Academic Medical Center of University of Amsterdam (AMC)
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- Prins, Niels D. (author)
- Academic Medical Center of University of Amsterdam (AMC)
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- Lammertsma, Adriaan A. (author)
- Academic Medical Center of University of Amsterdam (AMC)
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- Scheltens, Philip (author)
- Academic Medical Center of University of Amsterdam (AMC)
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- van der Flier, Wiesje M. (author)
- Academic Medical Center of University of Amsterdam (AMC)
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- van Berckel, Bart N.M. (author)
- Academic Medical Center of University of Amsterdam (AMC)
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(creator_code:org_t)
- Elsevier BV, 2019
- 2019
- English 9 s.
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In: Neurobiology of Aging. - : Elsevier BV. - 0197-4580. ; 79, s. 50-58
- Related links:
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http://dx.doi.org/10... (free)
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https://doi.org/10.1...
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https://doi.org/10.1...
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Abstract
Subject headings
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- We examined the relationships between amyloid-β PET and concurrent and longitudinal cognitive performance in 107 cognitively normal individuals with subjective cognitive decline (age: 64 ± 8 years, 44% female, Mini-Mental State Examination score 29 ± 1). All underwent 90-minute dynamic [ 18 F]florbetapir PET scanning and longitudinal neuropsychological tests with a mean follow-up of 3.4 ± 3.0 years. Receptor parametric mapping was used to calculate [ 18 F]florbetapir binding potential (BP ND ), and we performed linear mixed models to assess the relationships between global [ 18 F]florbetapir BP ND and neuropsychological performance. Higher [ 18 F]florbetapir BP ND was related to lower concurrent Mini-Mental State Examination (β ± SE: −1.69 ± 0.63 p < 0.01) and to steeper rate of decline on tasks capturing memory (Rey Auditory Verbal Learning Task immediate [β ± SE −1.81 ± 0.81, p < 0.05] and delayed recall [β ± SE −1.19 ± 0.34, p < 0.01]), attention/executive functions (Stroop II [color] [β ± SE −0.02 ± 0.01, p < 0.05], Stroop III [word-color] [β ± SE −0.03 ± 0.02, p < 0.05]), and language (category fluency [β ± SE −0.04 ± 0.01, p < 0.01]). These findings suggest that higher amyloid-β load in cognitively normal individuals with subjective cognitive decline from a memory clinic is associated with lower concurrent global cognition and with faster rate of decline in a variety of cognitive domains.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Amyloid-β
- Cognition
- Positron emission tomography (PET)
- Preclinical Alzheimer's disease
- Subjective cognitive decline (SCD)
Publication and Content Type
- art (subject category)
- ref (subject category)
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Timmers, Tessa
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Ossenkoppele, Ri ...
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Verfaillie, Sand ...
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van der Weijden, ...
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Slot, Rosalinde ...
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Wesselman, Linda ...
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Windhorst, Alber ...
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Wolters, Emma E.
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Yaqub, Maqsood
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Prins, Niels D.
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Lammertsma, Adri ...
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Scheltens, Phili ...
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van der Flier, W ...
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van Berckel, Bar ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
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Neurobiology of ...
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Lund University