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Capsule endoscopy i...
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Yung, Diana E.Royal Infirmary of Edinburgh
(author)
Capsule endoscopy in young patients with iron deficiency anaemia and negative bidirectional gastrointestinal endoscopy
- Article/chapterEnglish2017
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Numbers
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LIBRIS-ID:oai:lup.lub.lu.se:06fc5f7b-4704-42a1-962d-3fdb3839c2ea
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https://lup.lub.lu.se/record/06fc5f7b-4704-42a1-962d-3fdb3839c2eaURI
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https://doi.org/10.1177/2050640617692501DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
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Background: Recent data imply young patients (age ≤50 years) undergoing small-bowel (SB) capsule endoscopy (CE) for iron deficiency anaemia (IDA) show higher diagnostic yield (DY) for sinister pathology. We aimed to investigate DY of CE in a large cohort of young IDA patients, and evaluate factors predicting significant SB pathology. Materials and methods: This was a retrospective, multicentre study (2010–2015) in consecutive, young patients (≤50 years) from 18 centres/12 countries, with negative bidirectional gastrointestinal (GI) endoscopy undergoing SBCE for IDA. Exclusion criteria: previous/ongoing obscure-overt GI bleeding; age <19 or >50 years; comorbidities associated with IDA. Data retrieved: SBCE indications; prior investigations; medications; SBCE findings; final diagnosis. Clinical and laboratory data were analysed by multivariate logistic regression. Results: Data on 389 young IDA patients were retrieved. In total, 169 (43.4%) were excluded due to incomplete clinical data; data from 220 (122F/98M; mean age 40.5 ± 8.6 years) patients were analysed. Some 71 patients had at least one clinically significant SBCE finding (DY: 32.3%). They were divided into two groups: neoplastic pathology (10/220; 4.5%), and non-neoplastic but clinically significant pathology (61/220; 27.7%). The most common significant but non-neoplastic pathologies were angioectasias (22/61) and Crohn’s disease (15/61). On multivariate analysis, weight loss and lower mean corpuscular volume(MCV) were associated with significant SB pathology (OR: 3.87; 95%CI: 1.3–11.3; p = 0.01; and OR: 0.96; 95%CI: 0.92–0.99; p = 0.03; respectively). Our model also demonstrates association between use of antiplatelets and significant SB pathology, although due to the small number of patients, definitive conclusions cannot be drawn. Conclusion: In IDA patients ≤50 years with negative bidirectional GI endoscopy, overall DY of SBCE for clinically significant findings was 32.3%. Some 5% of our cohort was diagnosed with SB neoplasia; lower MCV or weight loss were associated with higher DY for SB pathology.
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Rondonotti, EmanueleValduce Hospital
(author)
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Giannakou, AndryOpen University of Cyprus
(author)
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Avni, TomerRabin Medical Center
(author)
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Rosa, BrunoHospital Senhora da Oliveira
(author)
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Toth, ErvinLund University,Lunds universitet,Gastroenterologi,Forskargrupper vid Lunds universitet,Gastroenterology,Lund University Research Groups,Skåne University Hospital(Swepub:lu)ront-eto
(author)
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Lucendo, Alfredo J.Hospital General de Tomelloso,CIBER Enfermedades Hepaticas y Digestivas (CIBER-ehd)
(author)
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Sidhu, ReenaRoyal Hallamshire Hospital
(author)
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Beaumont, HannekeAmsterdam UMC - Vrije Universiteit Amsterdam
(author)
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Ellul, PierreMater Dei Hospital
(author)
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Negreanu, LucianCarol Davila University of Medicine and Pharmacy
(author)
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Jiménez-Garcia, Victoria AlejandraUniversity Hospital Virgen Macarena
(author)
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McNamara, DeidreTrinity College Dublin
(author)
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Kopylov, UriTel-Aviv University
(author)
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Elli, LucaMaggiore Hospital Policlinico
(author)
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Triantafyllou, KonstantinosNational and Kapodistrian University of Athens
(author)
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Shibli, FahmiHaEmek Medical Center
(author)
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Riccioni, Maria ElenaCatholic University of the Sacred Heart, Rome
(author)
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Bruno, MauroCitta' della Salute e della Scienza Hospital-University of Turin
(author)
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Dray, XavierHospital Saint-Antoine
(author)
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Plevris, John N.Royal Infirmary of Edinburgh
(author)
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Koulaouzidis, A.Royal Infirmary of Edinburgh(Swepub:lu)med-aku
(author)
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Argüelles-Arias, FedericoUniversity Hospital Virgen Macarena
(author)
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Becq, AymericHospital Saint-Antoine
(author)
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Branchi, FedericaUniversity of Milan
(author)
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Tejero-Bustos, María ÁngelesHospital General de Tomelloso
(author)
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Cotter, JoseHospital Senhora da Oliveira
(author)
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Eliakim, RamiTel-Aviv University
(author)
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Ferretti, FrancescaUniversity of Milan
(author)
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Gralnek, Ian M.Technion - Israel Institute of Technology,HaEmek Medical Center
(author)
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Herrerias-Gutierrez, Juan ManuelUniversity Hospital Virgen Macarena
(author)
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Hussey, MaryTrinity College Dublin
(author)
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Jacobs, MaartenAmsterdam UMC - Vrije Universiteit Amsterdam
(author)
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Johansson, Gabriele WurmLund University,Lunds universitet,Gastroenterologi,Forskargrupper vid Lunds universitet,Gastroenterology,Lund University Research Groups,Skåne University Hospital(Swepub:lu)med-giw
(author)
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McAlindon, MarkRoyal Hallamshire Hospital
(author)
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Montiero, SaraHospital Senhora da Oliveira
(author)
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Nemeth, ArturLund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups,Skåne University Hospital(Swepub:lu)med-aun
(author)
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Pennazio, MarcoCitta' della Salute e della Scienza Hospital-University of Turin
(author)
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Rattehalli, DeepaRoyal Hallamshire Hospital
(author)
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Stemate, AnaCarol Davila University of Medicine and Pharmacy
(author)
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Tortora, AnnalisaCatholic University of the Sacred Heart, Rome
(author)
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Tziatzios, GeorgiosNational and Kapodistrian University of Athens
(author)
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Royal Infirmary of EdinburghValduce Hospital
(creator_code:org_t)
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And the Capsule Endoscopy in Young Patients with IDA research group
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In:United European Gastroenterology Journal: Wiley5:7, s. 974-9812050-64062050-6414
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Yung, Diana E.
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Rondonotti, Eman ...
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Giannakou, Andry
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Avni, Tomer
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Rosa, Bruno
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Toth, Ervin
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Lucendo, Alfredo ...
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Sidhu, Reena
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Beaumont, Hannek ...
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Ellul, Pierre
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Negreanu, Lucian
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Jiménez-Garcia, ...
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McNamara, Deidre
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Kopylov, Uri
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Elli, Luca
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Triantafyllou, K ...
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Shibli, Fahmi
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Riccioni, Maria ...
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Bruno, Mauro
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Dray, Xavier
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Plevris, John N.
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Koulaouzidis, A.
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Argüelles-Arias, ...
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Becq, Aymeric
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Branchi, Federic ...
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Tejero-Bustos, M ...
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Cotter, Jose
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Eliakim, Rami
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Ferretti, France ...
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Gralnek, Ian M.
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Herrerias-Gutier ...
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Hussey, Mary
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Jacobs, Maarten
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Johansson, Gabri ...
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McAlindon, Mark
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Montiero, Sara
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Nemeth, Artur
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Pennazio, Marco
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Rattehalli, Deep ...
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Stemate, Ana
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Tortora, Annalis ...
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Tziatzios, Georg ...
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