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  • Yung, Diana E.Royal Infirmary of Edinburgh (author)

Capsule endoscopy in young patients with iron deficiency anaemia and negative bidirectional gastrointestinal endoscopy

  • Article/chapterEnglish2017

Publisher, publication year, extent ...

  • 2017-02
  • Wiley,2017
  • 8 s.

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:06fc5f7b-4704-42a1-962d-3fdb3839c2ea
  • https://lup.lub.lu.se/record/06fc5f7b-4704-42a1-962d-3fdb3839c2eaURI
  • https://doi.org/10.1177/2050640617692501DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Background: Recent data imply young patients (age ≤50 years) undergoing small-bowel (SB) capsule endoscopy (CE) for iron deficiency anaemia (IDA) show higher diagnostic yield (DY) for sinister pathology. We aimed to investigate DY of CE in a large cohort of young IDA patients, and evaluate factors predicting significant SB pathology. Materials and methods: This was a retrospective, multicentre study (2010–2015) in consecutive, young patients (≤50 years) from 18 centres/12 countries, with negative bidirectional gastrointestinal (GI) endoscopy undergoing SBCE for IDA. Exclusion criteria: previous/ongoing obscure-overt GI bleeding; age <19 or >50 years; comorbidities associated with IDA. Data retrieved: SBCE indications; prior investigations; medications; SBCE findings; final diagnosis. Clinical and laboratory data were analysed by multivariate logistic regression. Results: Data on 389 young IDA patients were retrieved. In total, 169 (43.4%) were excluded due to incomplete clinical data; data from 220 (122F/98M; mean age 40.5 ± 8.6 years) patients were analysed. Some 71 patients had at least one clinically significant SBCE finding (DY: 32.3%). They were divided into two groups: neoplastic pathology (10/220; 4.5%), and non-neoplastic but clinically significant pathology (61/220; 27.7%). The most common significant but non-neoplastic pathologies were angioectasias (22/61) and Crohn’s disease (15/61). On multivariate analysis, weight loss and lower mean corpuscular volume(MCV) were associated with significant SB pathology (OR: 3.87; 95%CI: 1.3–11.3; p = 0.01; and OR: 0.96; 95%CI: 0.92–0.99; p = 0.03; respectively). Our model also demonstrates association between use of antiplatelets and significant SB pathology, although due to the small number of patients, definitive conclusions cannot be drawn. Conclusion: In IDA patients ≤50 years with negative bidirectional GI endoscopy, overall DY of SBCE for clinically significant findings was 32.3%. Some 5% of our cohort was diagnosed with SB neoplasia; lower MCV or weight loss were associated with higher DY for SB pathology.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Rondonotti, EmanueleValduce Hospital (author)
  • Giannakou, AndryOpen University of Cyprus (author)
  • Avni, TomerRabin Medical Center (author)
  • Rosa, BrunoHospital Senhora da Oliveira (author)
  • Toth, ErvinLund University,Lunds universitet,Gastroenterologi,Forskargrupper vid Lunds universitet,Gastroenterology,Lund University Research Groups,Skåne University Hospital(Swepub:lu)ront-eto (author)
  • Lucendo, Alfredo J.Hospital General de Tomelloso,CIBER Enfermedades Hepaticas y Digestivas (CIBER-ehd) (author)
  • Sidhu, ReenaRoyal Hallamshire Hospital (author)
  • Beaumont, HannekeAmsterdam UMC - Vrije Universiteit Amsterdam (author)
  • Ellul, PierreMater Dei Hospital (author)
  • Negreanu, LucianCarol Davila University of Medicine and Pharmacy (author)
  • Jiménez-Garcia, Victoria AlejandraUniversity Hospital Virgen Macarena (author)
  • McNamara, DeidreTrinity College Dublin (author)
  • Kopylov, UriTel-Aviv University (author)
  • Elli, LucaMaggiore Hospital Policlinico (author)
  • Triantafyllou, KonstantinosNational and Kapodistrian University of Athens (author)
  • Shibli, FahmiHaEmek Medical Center (author)
  • Riccioni, Maria ElenaCatholic University of the Sacred Heart, Rome (author)
  • Bruno, MauroCitta' della Salute e della Scienza Hospital-University of Turin (author)
  • Dray, XavierHospital Saint-Antoine (author)
  • Plevris, John N.Royal Infirmary of Edinburgh (author)
  • Koulaouzidis, A.Royal Infirmary of Edinburgh(Swepub:lu)med-aku (author)
  • Argüelles-Arias, FedericoUniversity Hospital Virgen Macarena (author)
  • Becq, AymericHospital Saint-Antoine (author)
  • Branchi, FedericaUniversity of Milan (author)
  • Tejero-Bustos, María ÁngelesHospital General de Tomelloso (author)
  • Cotter, JoseHospital Senhora da Oliveira (author)
  • Eliakim, RamiTel-Aviv University (author)
  • Ferretti, FrancescaUniversity of Milan (author)
  • Gralnek, Ian M.Technion - Israel Institute of Technology,HaEmek Medical Center (author)
  • Herrerias-Gutierrez, Juan ManuelUniversity Hospital Virgen Macarena (author)
  • Hussey, MaryTrinity College Dublin (author)
  • Jacobs, MaartenAmsterdam UMC - Vrije Universiteit Amsterdam (author)
  • Johansson, Gabriele WurmLund University,Lunds universitet,Gastroenterologi,Forskargrupper vid Lunds universitet,Gastroenterology,Lund University Research Groups,Skåne University Hospital(Swepub:lu)med-giw (author)
  • McAlindon, MarkRoyal Hallamshire Hospital (author)
  • Montiero, SaraHospital Senhora da Oliveira (author)
  • Nemeth, ArturLund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups,Skåne University Hospital(Swepub:lu)med-aun (author)
  • Pennazio, MarcoCitta' della Salute e della Scienza Hospital-University of Turin (author)
  • Rattehalli, DeepaRoyal Hallamshire Hospital (author)
  • Stemate, AnaCarol Davila University of Medicine and Pharmacy (author)
  • Tortora, AnnalisaCatholic University of the Sacred Heart, Rome (author)
  • Tziatzios, GeorgiosNational and Kapodistrian University of Athens (author)
  • Royal Infirmary of EdinburghValduce Hospital (creator_code:org_t)
  • And the Capsule Endoscopy in Young Patients with IDA research group

Related titles

  • In:United European Gastroenterology Journal: Wiley5:7, s. 974-9812050-64062050-6414

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