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Capsule endoscopy i...
Capsule endoscopy in young patients with iron deficiency anaemia and negative bidirectional gastrointestinal endoscopy
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- Yung, Diana E. (author)
- Royal Infirmary of Edinburgh
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- Rondonotti, Emanuele (author)
- Valduce Hospital
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- Giannakou, Andry (author)
- Open University of Cyprus
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- Avni, Tomer (author)
- Rabin Medical Center
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- Rosa, Bruno (author)
- Hospital Senhora da Oliveira
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- Toth, Ervin (author)
- Lund University,Lunds universitet,Gastroenterologi,Forskargrupper vid Lunds universitet,Gastroenterology,Lund University Research Groups,Skåne University Hospital
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- Lucendo, Alfredo J. (author)
- Hospital General de Tomelloso,CIBER Enfermedades Hepaticas y Digestivas (CIBER-ehd)
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- Sidhu, Reena (author)
- Royal Hallamshire Hospital
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- Beaumont, Hanneke (author)
- Amsterdam UMC - Vrije Universiteit Amsterdam
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- Ellul, Pierre (author)
- Mater Dei Hospital
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- Negreanu, Lucian (author)
- Carol Davila University of Medicine and Pharmacy
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- Jiménez-Garcia, Victoria Alejandra (author)
- University Hospital Virgen Macarena
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- McNamara, Deidre (author)
- Trinity College Dublin
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- Kopylov, Uri (author)
- Tel-Aviv University
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- Elli, Luca (author)
- Maggiore Hospital Policlinico
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- Triantafyllou, Konstantinos (author)
- National and Kapodistrian University of Athens
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- Shibli, Fahmi (author)
- HaEmek Medical Center
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- Riccioni, Maria Elena (author)
- Catholic University of the Sacred Heart, Rome
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- Bruno, Mauro (author)
- Citta' della Salute e della Scienza Hospital-University of Turin
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- Dray, Xavier (author)
- Hospital Saint-Antoine
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- Plevris, John N. (author)
- Royal Infirmary of Edinburgh
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- Koulaouzidis, A. (author)
- Royal Infirmary of Edinburgh
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- Argüelles-Arias, Federico (author)
- University Hospital Virgen Macarena
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- Becq, Aymeric (author)
- Hospital Saint-Antoine
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- Branchi, Federica (author)
- University of Milan
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- Tejero-Bustos, María Ángeles (author)
- Hospital General de Tomelloso
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- Cotter, Jose (author)
- Hospital Senhora da Oliveira
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- Eliakim, Rami (author)
- Tel-Aviv University
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- Ferretti, Francesca (author)
- University of Milan
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- Gralnek, Ian M. (author)
- Technion - Israel Institute of Technology,HaEmek Medical Center
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- Herrerias-Gutierrez, Juan Manuel (author)
- University Hospital Virgen Macarena
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- Hussey, Mary (author)
- Trinity College Dublin
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- Jacobs, Maarten (author)
- Amsterdam UMC - Vrije Universiteit Amsterdam
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- Johansson, Gabriele Wurm (author)
- Lund University,Lunds universitet,Gastroenterologi,Forskargrupper vid Lunds universitet,Gastroenterology,Lund University Research Groups,Skåne University Hospital
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- McAlindon, Mark (author)
- Royal Hallamshire Hospital
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- Montiero, Sara (author)
- Hospital Senhora da Oliveira
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- Nemeth, Artur (author)
- Lund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups,Skåne University Hospital
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- Pennazio, Marco (author)
- Citta' della Salute e della Scienza Hospital-University of Turin
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- Rattehalli, Deepa (author)
- Royal Hallamshire Hospital
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- Stemate, Ana (author)
- Carol Davila University of Medicine and Pharmacy
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- Tortora, Annalisa (author)
- Catholic University of the Sacred Heart, Rome
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- Tziatzios, Georgios (author)
- National and Kapodistrian University of Athens
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(creator_code:org_t)
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- 2017-02
- 2017
- English 8 s.
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In: United European Gastroenterology Journal. - : Wiley. - 2050-6406 .- 2050-6414. ; 5:7, s. 974-981
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http://dx.doi.org/10...
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Abstract
Subject headings
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- Background: Recent data imply young patients (age ≤50 years) undergoing small-bowel (SB) capsule endoscopy (CE) for iron deficiency anaemia (IDA) show higher diagnostic yield (DY) for sinister pathology. We aimed to investigate DY of CE in a large cohort of young IDA patients, and evaluate factors predicting significant SB pathology. Materials and methods: This was a retrospective, multicentre study (2010–2015) in consecutive, young patients (≤50 years) from 18 centres/12 countries, with negative bidirectional gastrointestinal (GI) endoscopy undergoing SBCE for IDA. Exclusion criteria: previous/ongoing obscure-overt GI bleeding; age <19 or >50 years; comorbidities associated with IDA. Data retrieved: SBCE indications; prior investigations; medications; SBCE findings; final diagnosis. Clinical and laboratory data were analysed by multivariate logistic regression. Results: Data on 389 young IDA patients were retrieved. In total, 169 (43.4%) were excluded due to incomplete clinical data; data from 220 (122F/98M; mean age 40.5 ± 8.6 years) patients were analysed. Some 71 patients had at least one clinically significant SBCE finding (DY: 32.3%). They were divided into two groups: neoplastic pathology (10/220; 4.5%), and non-neoplastic but clinically significant pathology (61/220; 27.7%). The most common significant but non-neoplastic pathologies were angioectasias (22/61) and Crohn’s disease (15/61). On multivariate analysis, weight loss and lower mean corpuscular volume(MCV) were associated with significant SB pathology (OR: 3.87; 95%CI: 1.3–11.3; p = 0.01; and OR: 0.96; 95%CI: 0.92–0.99; p = 0.03; respectively). Our model also demonstrates association between use of antiplatelets and significant SB pathology, although due to the small number of patients, definitive conclusions cannot be drawn. Conclusion: In IDA patients ≤50 years with negative bidirectional GI endoscopy, overall DY of SBCE for clinically significant findings was 32.3%. Some 5% of our cohort was diagnosed with SB neoplasia; lower MCV or weight loss were associated with higher DY for SB pathology.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
Keyword
- Capsule endoscopy
- iron deficiency anaemia
- neoplasia
- small bowel
- young
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Yung, Diana E.
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Rondonotti, Eman ...
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Giannakou, Andry
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Avni, Tomer
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Rosa, Bruno
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Toth, Ervin
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show more...
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Lucendo, Alfredo ...
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Sidhu, Reena
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Beaumont, Hannek ...
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Ellul, Pierre
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Negreanu, Lucian
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Jiménez-Garcia, ...
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McNamara, Deidre
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Kopylov, Uri
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Elli, Luca
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Triantafyllou, K ...
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Shibli, Fahmi
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Riccioni, Maria ...
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Bruno, Mauro
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Dray, Xavier
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Plevris, John N.
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Koulaouzidis, A.
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Argüelles-Arias, ...
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Becq, Aymeric
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Branchi, Federic ...
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Tejero-Bustos, M ...
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Cotter, Jose
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Eliakim, Rami
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Ferretti, France ...
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Gralnek, Ian M.
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Herrerias-Gutier ...
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Hussey, Mary
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Jacobs, Maarten
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Johansson, Gabri ...
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McAlindon, Mark
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Montiero, Sara
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Nemeth, Artur
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Pennazio, Marco
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Rattehalli, Deep ...
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Stemate, Ana
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Tortora, Annalis ...
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Tziatzios, Georg ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Gastroenterology ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Surgery
- Articles in the publication
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United European ...
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Lund University