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(WFRF:(Morgan Matt P.G.)) pers:(Ullén Susann)
 

Search: (WFRF:(Morgan Matt P.G.)) pers:(Ullén Susann) > Renal function afte...

  • Rundgren, MalinLund University,Lunds universitet,Anestesiologi och intensivvård,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Centrum för hjärtstopp,Forskargrupper vid Lunds universitet,Anesthesiology and Intensive Care,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Center for cardiac arrest,Lund University Research Groups,Skåne University Hospital (author)

Renal function after out-of-hospital cardiac arrest; The influence of temperature management and coronary angiography, a post hoc study of the target temperature management trial

  • Article/chapterEnglish2019

Publisher, publication year, extent ...

  • 2019-05-08
  • Springer Science and Business Media LLC,2019

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  • LIBRIS-ID:oai:lup.lub.lu.se:0703104e-302b-4a9c-8b9e-3024c43b69fc
  • https://lup.lub.lu.se/record/0703104e-302b-4a9c-8b9e-3024c43b69fcURI
  • https://doi.org/10.1186/s13054-019-2390-0DOI

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  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Background: To elucidate the incidence of acute kidney injury (AKI) after out-of-hospital cardiac arrest (OHCA) and to examine the impact of target temperature management (TTM) and early coronary angiography on renal function. Methods: Post hoc analysis of the TTM trial, a multinational randomised controlled trial comparing target temperature of 33 °C versus 36 °C in patients with return of spontaneous circulation after OHCA. The impact of TTM and early angiography (within 6 h of OHCA) versus late or no angiography on the development of AKI during the 7-day period after OHCA was analysed. AKI was defined according to modified KDIGO criteria in patients surviving beyond day 2 after OHCA. Results: Following exclusions, 853 of 939 patients enrolled in the main trial were analysed. Unadjusted analysis showed that significantly more patients in the 33 °C group had AKI compared to the 36 °C group [211/431 (49%) versus 170/422 (40%) p = 0.01], with a worse severity (p = 0.018). After multivariable adjustment, the difference was not significant (odds ratio 0.75, 95% confidence interval 0.54-1.06, p = 0.10]. Five hundred seventeen patients underwent early coronary angiography. Although the unadjusted analysis showed less AKI and less severe AKI in patients who underwent early angiography compared to patients with late or no angiography, in adjusted analyses, early angiography was not an independent risk factor for AKI (odds ratio 0.73, 95% confidence interval 0.50-1.05, p = 0.09). Conclusions: In OHCA survivors, TTM at 33 °C compared to management at 36 °C did not show different rates of AKI and early angiography was not associated with an increased risk of AKI. Trial registration: NCT01020916. Registered on www.ClinicalTrials.gov 26 November 2009 (main trial).

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  • Ullén, SusannSkåne University Hospital(Swepub:lu)su7040ul (author)
  • Morgan, Matt P.G.Cardiff University (author)
  • Glover, GuyKing's College London,Guy's and St Thomas' NHS Foundation Trust (author)
  • Cranshaw, JuliusRoyal Bournemouth Hospital (author)
  • Al-Subaie, NawafSt George's Hospital, London (author)
  • Walden, AndrewRoyal Berkshire Hospital (author)
  • Joannidis, MichaelMedical University of Innsbruck (author)
  • Ostermann, MarliesKing's College London,Guy's and St Thomas' NHS Foundation Trust (author)
  • Dankiewicz, JosefLund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital(Swepub:lu)med-jfd (author)
  • Nielsen, NiklasHelsingborg Hospital(Swepub:lu)med-nni (author)
  • Wise, Matthew P.University Hospital of Wales (author)
  • Anestesiologi och intensivvårdSektion II (creator_code:org_t)

Related titles

  • In:Critical Care: Springer Science and Business Media LLC23:11364-8535

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