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Sökning: WFRF:(Hyland M) > (2020-2023) > The influence of fi...

  • Conway, Marie CUniversity of Ulster (författare)

The influence of fish consumption on serum n-3 polyunsaturated fatty acid (PUFA) concentrations in women of childbearing age : a randomised controlled trial (the iFish Study)

  • Artikel/kapitelEngelska2021

Förlag, utgivningsår, omfång ...

  • 2020-07-28
  • Springer Science and Business Media LLC,2021

Nummerbeteckningar

  • LIBRIS-ID:oai:lup.lub.lu.se:070a37ca-29cb-44ab-ac01-146c7c646fd0
  • https://lup.lub.lu.se/record/070a37ca-29cb-44ab-ac01-146c7c646fd0URI
  • https://doi.org/10.1007/s00394-020-02326-wDOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:144227339URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:art swepub-publicationtype
  • Ämneskategori:ref swepub-contenttype

Anmärkningar

  • PURPOSE: Long-chain polyunsaturated fatty acids (LCPUFA) can be synthesised endogenously from linoleic acid (LA) and α-linolenic acid (ALA) in a pathway involving the fatty acid desaturase (FADS) genes. Endogenous synthesis is inefficient; therefore, dietary intake of preformed LCPUFA from their richest source of fish is preferred. This study investigated the effect of fish consumption on PUFA concentrations in women of childbearing age while stratifying by FADS genotype. The influence of fish consumption on lipid profile, and markers of inflammation and oxidative stress was also examined.METHODS: Healthy women (n = 49) provided a buccal swab which was analysed for FADS2 genotype (rs3834458; T/deletion). Participants were stratified according to genotype and randomised to an intervention group to receive either no fish (n = 18), 1 portion (n = 14) or 2 portions (n = 17) (140 g per portion) of fish per week for a period of 8 weeks. Serum PUFA was analysed at baseline and post-intervention. Lipid profile, and markers of inflammation and oxidative stress were also analysed.RESULTS: Participants consuming 2 portions of fish per week had significantly higher concentrations of eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA) and total n-3 PUFA, and a lower n-6:n-3 ratio compared to those in the no fish or 1 portion per week group (all p < 0.05). Fish consumption did not have a significant effect on biomarkers of oxidative stress, inflammation and lipid profile in the current study.CONCLUSION: Consumption of 2 portions of fish per week has beneficial effects on biological n-3 PUFA concentrations in women of childbearing age; however, no effects on oxidative stress, inflammation or lipid profile were observed. This trial was registered at www.clinicaltrials.gov (NCT03765580), registered December 2018.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • McSorley, Emeir MUniversity of Ulster (författare)
  • Mulhern, Maria SUniversity of Ulster (författare)
  • Spence, ToniUniversity of Ulster (författare)
  • Wijngaarden, Edwin vanUniversity of Rochester School of Medicine and Dentistry (författare)
  • Watson, Gene EUniversity of Rochester School of Medicine and Dentistry (författare)
  • Wahlberg, KarinLund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Genetisk arbets- och miljömedicin,Forskargrupper vid Lunds universitet,Tillämpad masspektrometri inom miljömedicin,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine,Genetic Occupational and Environmental Medicine,Lund University Research Groups,Applied Mass Spectrometry in Environmental Medicine(Swepub:lu)immu-kwa (författare)
  • Pineda, DanielaLund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Genetisk arbets- och miljömedicin,Forskargrupper vid Lunds universitet,Tillämpad masspektrometri inom miljömedicin,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine,Genetic Occupational and Environmental Medicine,Lund University Research Groups,Applied Mass Spectrometry in Environmental Medicine(Swepub:lu)med-dip (författare)
  • Broberg, KarinKarolinska Institutet,Karolinska Institute,Lund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Genetisk arbets- och miljömedicin,Forskargrupper vid Lunds universitet,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine,Genetic Occupational and Environmental Medicine,Lund University Research Groups(Swepub:lu)kgen-kbr (författare)
  • Hyland, Barry WUniversity of Ulster (författare)
  • Cobice, Diego FUniversity of Ulster (författare)
  • Strain, J JUniversity of Ulster (författare)
  • Yeates, Alison JUniversity of Ulster (författare)
  • University of UlsterUniversity of Rochester School of Medicine and Dentistry (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:European Journal of Nutrition: Springer Science and Business Media LLC60:3, s. 1415-14271436-62151436-6207

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