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  • Blalock, Zachary N.University of California, San Francisco (författare)

Circulating cell-free mitochondrial DNA levels and glucocorticoid sensitivity in a cohort of male veterans with and without combat-related PTSD

  • Artikel/kapitelEngelska2024

Förlag, utgivningsår, omfång ...

  • 2024

Nummerbeteckningar

  • LIBRIS-ID:oai:lup.lub.lu.se:07137567-e5b3-40ec-9de7-921c46ceb269
  • https://lup.lub.lu.se/record/07137567-e5b3-40ec-9de7-921c46ceb269URI
  • https://doi.org/10.1038/s41398-023-02721-xDOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

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  • Ämneskategori:art swepub-publicationtype
  • Ämneskategori:ref swepub-contenttype

Anmärkningar

  • Circulating cell-free mitochondrial DNA (ccf-mtDNA) is a biomarker of cellular injury or cellular stress and is a potential novel biomarker of psychological stress and of various brain, somatic, and psychiatric disorders. No studies have yet analyzed ccf-mtDNA levels in post-traumatic stress disorder (PTSD), despite evidence of mitochondrial dysfunction in this condition. In the current study, we compared plasma ccf-mtDNA levels in combat trauma-exposed male veterans with PTSD (n = 111) with those who did not develop PTSD (n = 121) and also investigated the relationship between ccf mt-DNA levels and glucocorticoid sensitivity. In unadjusted analyses, ccf-mtDNA levels did not differ significantly between the PTSD and non-PTSD groups (t = 1.312, p = 0.191, Cohen’s d = 0.172). In a sensitivity analysis excluding participants with diabetes and those using antidepressant medication and controlling for age, the PTSD group had lower ccf-mtDNA levels than did the non-PTSD group (F(1, 179) = 5.971, p = 0.016, partial η 2 = 0.033). Across the entire sample, ccf-mtDNA levels were negatively correlated with post-dexamethasone adrenocorticotropic hormone (ACTH) decline (r = −0.171, p = 0.020) and cortisol decline (r = −0.149, p = 0.034) (viz., greater ACTH and cortisol suppression was associated with lower ccf-mtDNA levels) both with and without controlling for age, antidepressant status and diabetes status. Ccf-mtDNA levels were also significantly positively associated with IC50-DEX (the concentration of dexamethasone at which 50% of lysozyme activity is inhibited), a measure of lymphocyte glucocorticoid sensitivity, after controlling for age, antidepressant status, and diabetes status (β = 0.142, p = 0.038), suggesting that increased lymphocyte glucocorticoid sensitivity is associated with lower ccf-mtDNA levels. Although no overall group differences were found in unadjusted analyses, excluding subjects with diabetes and those taking antidepressants, which may affect ccf-mtDNA levels, as well as controlling for age, revealed decreased ccf-mtDNA levels in PTSD. In both adjusted and unadjusted analyses, low ccf-mtDNA levels were associated with relatively increased glucocorticoid sensitivity, often reported in PTSD, suggesting a link between mitochondrial and glucocorticoid-related abnormalities in PTSD.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Wu, Gwyneth W.Y.University of California, San Francisco (författare)
  • Lindqvist, DanielLund University,Lunds universitet,Psykiatri, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,LU profilområde: Proaktivt åldrande,Lunds universitets profilområden,Psychiatry (Lund),Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,LU Profile Area: Proactive Ageing,Lund University Profile areas(Swepub:lu)med-del (författare)
  • Trumpff, CarolineColumbia University (författare)
  • Flory, Janine D.Icahn School of Medicine at Mount Sinai,Veterans Health Administration (författare)
  • Lin, JueUniversity of California, San Francisco (författare)
  • Reus, Victor I.University of California, San Francisco (författare)
  • Rampersaud, RyanUniversity of California, San Francisco (författare)
  • Hammamieh, RashaUS Army Medical Research and Materiel Command (författare)
  • Gautam, AartiUS Army Medical Research and Materiel Command (författare)
  • Ressler, Kerry J.Harvard Medical School (författare)
  • Yang, RuotingUS Army Medical Research and Materiel Command (författare)
  • Muhie, SeidUS Army Medical Research and Materiel Command (författare)
  • Daigle, Bernie J.University of Memphis (författare)
  • Bierer, Linda M.Icahn School of Medicine at Mount Sinai,Veterans Health Administration (författare)
  • Hood, LeroyInstitute for Systems Biology, Seattle (författare)
  • Wang, KaiInstitute for Systems Biology, Seattle (författare)
  • Lee, InyoulInstitute for Systems Biology, Seattle (författare)
  • Dean, Kelsey R.Harvard John A. Paulson School of Engineering and Applied Sciences (författare)
  • Somvanshi, Pramod R.Harvard John A. Paulson School of Engineering and Applied Sciences (författare)
  • Doyle, Francis J.Harvard John A. Paulson School of Engineering and Applied Sciences (författare)
  • Marmar, Charles R.NYU Grossman School of Medicine (författare)
  • Jett, MartiUS Army Medical Research and Materiel Command (författare)
  • Yehuda, RachelVeterans Health Administration,Icahn School of Medicine at Mount Sinai (författare)
  • Wolkowitz, Owen M.University of California, San Francisco(Swepub:lu)ow2624wo (författare)
  • Mellon, Synthia H.University of California, San Francisco (författare)
  • University of California, San FranciscoPsykiatri, Lund (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Translational Psychiatry14:12158-3188

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