Search: WFRF:(Daigle Bernie J.) >
Circulating cell-fr...
Circulating cell-free mitochondrial DNA levels and glucocorticoid sensitivity in a cohort of male veterans with and without combat-related PTSD
-
- Blalock, Zachary N. (author)
- University of California, San Francisco
-
- Wu, Gwyneth W.Y. (author)
- University of California, San Francisco
-
- Lindqvist, Daniel (author)
- Lund University,Lunds universitet,Psykiatri, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,LU profilområde: Proaktivt åldrande,Lunds universitets profilområden,Psychiatry (Lund),Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,LU Profile Area: Proactive Ageing,Lund University Profile areas
-
show more...
-
- Trumpff, Caroline (author)
- Columbia University
-
- Flory, Janine D. (author)
- Icahn School of Medicine at Mount Sinai,Veterans Health Administration
-
- Lin, Jue (author)
- University of California, San Francisco
-
- Reus, Victor I. (author)
- University of California, San Francisco
-
- Rampersaud, Ryan (author)
- University of California, San Francisco
-
- Hammamieh, Rasha (author)
- US Army Medical Research and Materiel Command
-
- Gautam, Aarti (author)
- US Army Medical Research and Materiel Command
-
- Ressler, Kerry J. (author)
- Harvard Medical School
-
- Yang, Ruoting (author)
- US Army Medical Research and Materiel Command
-
- Muhie, Seid (author)
- US Army Medical Research and Materiel Command
-
- Daigle, Bernie J. (author)
- University of Memphis
-
- Bierer, Linda M. (author)
- Veterans Health Administration,Icahn School of Medicine at Mount Sinai
-
- Hood, Leroy (author)
- Institute for Systems Biology, Seattle
-
- Wang, Kai (author)
- Institute for Systems Biology, Seattle
-
- Lee, Inyoul (author)
- Institute for Systems Biology, Seattle
-
- Dean, Kelsey R. (author)
- Harvard John A. Paulson School of Engineering and Applied Sciences
-
- Somvanshi, Pramod R. (author)
- Harvard John A. Paulson School of Engineering and Applied Sciences
-
- Doyle, Francis J. (author)
- Harvard John A. Paulson School of Engineering and Applied Sciences
-
- Marmar, Charles R. (author)
- NYU Grossman School of Medicine
-
- Jett, Marti (author)
- US Army Medical Research and Materiel Command
-
- Yehuda, Rachel (author)
- Veterans Health Administration,Icahn School of Medicine at Mount Sinai
-
- Wolkowitz, Owen M. (author)
- University of California, San Francisco
-
- Mellon, Synthia H. (author)
- University of California, San Francisco
-
show less...
-
(creator_code:org_t)
- 2024
- 2024
- English.
-
In: Translational Psychiatry. - 2158-3188. ; 14:1
- Related links:
-
http://dx.doi.org/10... (free)
-
show more...
-
https://lup.lub.lu.s...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- Circulating cell-free mitochondrial DNA (ccf-mtDNA) is a biomarker of cellular injury or cellular stress and is a potential novel biomarker of psychological stress and of various brain, somatic, and psychiatric disorders. No studies have yet analyzed ccf-mtDNA levels in post-traumatic stress disorder (PTSD), despite evidence of mitochondrial dysfunction in this condition. In the current study, we compared plasma ccf-mtDNA levels in combat trauma-exposed male veterans with PTSD (n = 111) with those who did not develop PTSD (n = 121) and also investigated the relationship between ccf mt-DNA levels and glucocorticoid sensitivity. In unadjusted analyses, ccf-mtDNA levels did not differ significantly between the PTSD and non-PTSD groups (t = 1.312, p = 0.191, Cohen’s d = 0.172). In a sensitivity analysis excluding participants with diabetes and those using antidepressant medication and controlling for age, the PTSD group had lower ccf-mtDNA levels than did the non-PTSD group (F(1, 179) = 5.971, p = 0.016, partial η 2 = 0.033). Across the entire sample, ccf-mtDNA levels were negatively correlated with post-dexamethasone adrenocorticotropic hormone (ACTH) decline (r = −0.171, p = 0.020) and cortisol decline (r = −0.149, p = 0.034) (viz., greater ACTH and cortisol suppression was associated with lower ccf-mtDNA levels) both with and without controlling for age, antidepressant status and diabetes status. Ccf-mtDNA levels were also significantly positively associated with IC50-DEX (the concentration of dexamethasone at which 50% of lysozyme activity is inhibited), a measure of lymphocyte glucocorticoid sensitivity, after controlling for age, antidepressant status, and diabetes status (β = 0.142, p = 0.038), suggesting that increased lymphocyte glucocorticoid sensitivity is associated with lower ccf-mtDNA levels. Although no overall group differences were found in unadjusted analyses, excluding subjects with diabetes and those taking antidepressants, which may affect ccf-mtDNA levels, as well as controlling for age, revealed decreased ccf-mtDNA levels in PTSD. In both adjusted and unadjusted analyses, low ccf-mtDNA levels were associated with relatively increased glucocorticoid sensitivity, often reported in PTSD, suggesting a link between mitochondrial and glucocorticoid-related abnormalities in PTSD.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
Find in a library
To the university's database
- By the author/editor
-
Blalock, Zachary ...
-
Wu, Gwyneth W.Y.
-
Lindqvist, Danie ...
-
Trumpff, Carolin ...
-
Flory, Janine D.
-
Lin, Jue
-
show more...
-
Reus, Victor I.
-
Rampersaud, Ryan
-
Hammamieh, Rasha
-
Gautam, Aarti
-
Ressler, Kerry J ...
-
Yang, Ruoting
-
Muhie, Seid
-
Daigle, Bernie J ...
-
Bierer, Linda M.
-
Hood, Leroy
-
Wang, Kai
-
Lee, Inyoul
-
Dean, Kelsey R.
-
Somvanshi, Pramo ...
-
Doyle, Francis J ...
-
Marmar, Charles ...
-
Jett, Marti
-
Yehuda, Rachel
-
Wolkowitz, Owen ...
-
Mellon, Synthia ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Health Sciences
-
and Occupational Hea ...
- Articles in the publication
-
Translational Ps ...
- By the university
-
Lund University