Genetic modification of ALAD and VDR on lead-induced impairment of hearing in children.

Pawlas, NataliaInstitute of Occupational Medicine and Environmental Health (författare)

Polymorphisms in the δ-aminolevulinic acid dehydratase (ALAD) and the vitamin D receptor (VDR) genes may modify lead metabolism and neurotoxicity. Two cohorts of children were examined for hearing [pure-tone audiometry (PTA), brain stem auditory evoked potentials (BAEP)], acoustic otoemission (transient emission evoked by a click) and blood-lead concentrations (B-Pb). The children were genotyped for polymorphisms in ALAD and VDR. The median B-Pbs were 55 and 36μg/L in the two cohorts (merged cohort 45μg/L). B-Pb was significantly associated with impaired hearing when tested with PTA (correlation coefficient rS=0.12; P<0.01), BAEP (rS=0.18; P<0.001) and otoemission (rS=-0.24; P<0.001). VDR significantly modified the lead-induced effects on PTA. Carriers of the VDR alleles BsmI B, VDR TaqI t and VDR FokI F showed greater toxic effects on PTA, compared to BsmI bb, VDR TaqI TT and VDR FokI ff carriers. No significant interaction was found for ALAD. Lead impairs hearing functions in the route from the cochlea to the brain stem at low-level exposure, and polymorphisms in VDR significantly modify these effects.

Broberg Palmgren, KarinLund University,Lunds universitet,Genetisk arbets- och miljömedicin,Forskargrupper vid Lunds universitet,Genetic Occupational and Environmental Medicine,Lund University Research Groups(Swepub:lu)kgen-kbr (författare)
Olewińska, ElżbietaInstitute of Occupational Medicine and Environmental Health (författare)
Kozłowska, AgnieszkaInstitute of Occupational Medicine and Environmental Health (författare)
Skerfving, StaffanLund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine(Swepub:lu)ymed-ssk (författare)
Pawlas, KrystynaWroclaw University (författare)
Institute of Occupational Medicine and Environmental HealthGenetisk arbets- och miljömedicin (creator_code:org_t)

Ingår i:Environmental Toxicology and Pharmacology: Elsevier BV39:3, s. 1091-10981872-70771382-6689

Av författaren/redakt...: Pawlas, Natalia; Broberg Palmgren ...; Olewińska, Elżbi ...; Kozłowska, Agnie ...; Skerfving, Staff ...; Pawlas, Krystyna

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Hälsovetenskap; och Arbetsmedicin oc ...

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