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Standardization of ...
Standardization of clinical outcomes used in allergen immunotherapy in allergic asthma : An EAACI position paper
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- Kappen, Jasper (author)
- Imperial College London
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- Diamant, Zuzana (author)
- Lund University,Lunds universitet,Lungmedicin, allergologi och palliativ medicin,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Respiratory Medicine, Allergology, and Palliative Medicine,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,University Medical Center Groningen,Charles University in Prague,Catholic University of Leuven,Skåne University Hospital
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- Agache, Ioana (author)
- Transylvania University Brasov
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- Bonini, Matteo (author)
- Imperial College London,Policlinico Universitario Agostino Gemelli,Catholic University of the Sacred Heart, Rome
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- Bousquet, Jean (author)
- Charité - University Medicine Berlin
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- Canonica, G. Walter (author)
- Humanitas Research Hospital
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- Durham, Stephen R. (author)
- Imperial College London
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- Guibas, George V. (author)
- Royal Preston Hospital,University of Manchester
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- Hamelmann, Eckard (author)
- Bielefeld University
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- Jutel, Marek (author)
- Wrocław Medical University
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- Papadopoulos, Nikolaos G. (author)
- National and Kapodistrian University of Athens
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- Roberts, Graham (author)
- St Mary’s Hospital,University of Southampton
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- Shamji, Mohamed H. (author)
- Imperial College London
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- Zieglmayer, Petra (author)
- Karl Landsteiner University of Health Sciences
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- Gerth van Wijk, Roy (author)
- Erasmus University Medical Center
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- Pfaar, Oliver (author)
- University Hospital Giessen and Marburg
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(creator_code:org_t)
- 2023
- 2023
- English.
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In: Allergy: European Journal of Allergy and Clinical Immunology. - 0105-4538. ; 78:11, s. 2835-2850
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http://dx.doi.org/10... (free)
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Abstract
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- Introduction: In allergic asthma patients, one of the more common phenotypes might benefit from allergen immunotherapy (AIT) as add-on intervention to pharmacological treatment. AIT is a treatment with disease-modifying modalities, the evidence for efficacy is based on controlled clinical trials following standardized endpoint measures. However, so far there is a lack of a consensus for asthma endpoints in AIT trials. The aim of a task force (TF) of the European Academy of Allergy and Clinical Immunology (EAACI) is evaluating several outcome measures for AIT in allergic asthma. Methods: The following domains of outcome measures in asthmatic patients have been evaluated for this position paper (PP): (i) exacerbation rate, (ii) lung function, (iii) ICS withdrawal, (iv) symptoms and rescue medication use, (v) questionnaires (PROMS), (vi) bronchial/nasal provocation, (vii) allergen exposure chambers (AEC) and (viii) biomarkers. Results: Exacerbation rate can be used as a reliable objective primary outcome; however, there is limited evidence due to different definitions of exacerbation. The time after ICS withdrawal to first exacerbation is considered a primary outcome measure. Besides, the advantages and disadvantages and clinical implications of further domains of asthma endpoints in AIT trials are elaborated in this PP. Conclusion: This EAACI-PP aims to highlight important aspects of current asthma measures by critically evaluating their applicability for controlled trials of AIT.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
Keyword
- allergen immunotherapy
- allergy
- asthma
- clinical outcomes
- subcutaneous
- sublingual
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Kappen, Jasper
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Diamant, Zuzana
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Agache, Ioana
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Bonini, Matteo
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Bousquet, Jean
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Canonica, G. Wal ...
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Durham, Stephen ...
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Guibas, George V ...
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Hamelmann, Eckar ...
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Jutel, Marek
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Papadopoulos, Ni ...
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Roberts, Graham
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Shamji, Mohamed ...
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Zieglmayer, Petr ...
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Gerth van Wijk, ...
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Pfaar, Oliver
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Respiratory Medi ...
- Articles in the publication
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Allergy: Europea ...
- By the university
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Lund University