WFRF:(Boukarabila Hanane)
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The earliest thymic T cell progenitors sustain B cell and myeloid lineage potential.
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- Luc, Sidinh (author)
- Lund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine
- Luis, Tiago C (author)
- Boukarabila, Hanane (author)
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- Macaulay, Iain C (author)
- Bouriez-Jones, Tiphaine (author)
- Lutteropp, Michael (author)
- Woll, Petter S (author)
- Loughran, Stephen J (author)
- Mead, Adam J (author)
- Brown, John (author)
- Mizukami, Takuo (author)
- Matsuoka, Sahoko (author)
- Ferry, Helen (author)
- Anderson, Kristina (author)
- Duarte, Sara (author)
- Atkinson, Deborah (author)
- Domanski, Aniela (author)
- Farley, Alison (author)
- Sanjuan-Pla, Alejandra (author)
- Carella, Cintia (author)
- Patient, Roger (author)
- de Bruijn, Marella (author)
- Enver, Tariq (author)
- Nerlov, Claus (author)
- Blackburn, Clare (author)
- Godin, Isabelle (author)
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- (creator_code:org_t)
- 2012-02-19
- 2012
- English.
- In: Nature Immunology. - : Springer Science and Business Media LLC. - 1529-2908 .- 1529-2916. ; 13:4, s. 412-419
- Journal article (peer-reviewed)
Abstract
Subject headings
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- The stepwise commitment from hematopoietic stem cells in the bone marrow to T lymphocyte-restricted progenitors in the thymus represents a paradigm for understanding the requirement for distinct extrinsic cues during different stages of lineage restriction from multipotent to lineage-restricted progenitors. However, the commitment stage at which progenitors migrate from the bone marrow to the thymus remains unclear. Here we provide functional and molecular evidence at the single-cell level that the earliest progenitors in the neonatal thymus had combined granulocyte-monocyte, T lymphocyte and B lymphocyte lineage potential but not megakaryocyte-erythroid lineage potential. These potentials were identical to those of candidate thymus-seeding progenitors in the bone marrow, which were closely related at the molecular level. Our findings establish the distinct lineage-restriction stage at which the T cell lineage-commitment process transits from the bone marrow to the remote thymus.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
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- Luc, Sidinh
- Luis, Tiago C
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- Lutteropp, Micha ...
- Woll, Petter S
- Loughran, Stephe ...
- Mead, Adam J
- Hultquist, Anne
- Brown, John
- Mizukami, Takuo
- Matsuoka, Sahoko
- Ferry, Helen
- Anderson, Kristi ...
- Duarte, Sara
- Atkinson, Debora ...
- Soneji, Shamit
- Domanski, Aniela
- Farley, Alison
- Sanjuan-Pla, Ale ...
- Carella, Cintia
- Patient, Roger
- de Bruijn, Marel ...
- Enver, Tariq
- Nerlov, Claus
- Blackburn, Clare
- Godin, Isabelle
- Jacobsen, Sten E ...
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- Karolinska Institutet
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